Trial · NCT04577547
Registered outcomes18
Each outcome the trial registered, primary first, in ClinicalTrials.gov's words.
1 to 18 of 18
Download this page as JSON| List | Outcome | Time frame | Description |
|---|---|---|---|
| Primary | Change in C-reactive protein (CRP) | Weeks 0, 2, 4, 6, 8, 10, 12, 24 | The effect of diet and exercise on CRP |
| Primary | Relative reinforcing value (RRV) of energy-dense snack foods | Weeks 0,12, 24 | The effect of consuming a healthy DGA style or a Western style diet during weight loss and weight maintenance on the RRV of energy-dense snack food using a computer choice paradigm. For the computer choice paradigm subjects click the mouse button to play a simulated slot machine games to earn points toward receiving a portion of food or being able to do a non-food related sedentary activity (e.g., watching TV). |
| Primary | Relative reinforcing value (RRV) of exercise | Weeks 0,12, 24 | The effect of achieving the DGA recommended amounts of exercise during weight loss and weight maintenance on relative reinforcing value of exercise compared to a sedentary activity alternative using a computer choice paradigm. For the computer choice paradigm subjects click the mouse button to play a simulated slot machine games to earn points toward being able to do a chosen physical activity, such as walking on a treadmill, or a sedentary activity (e.g., watching TV). |
| Primary | Fat and carbohydrate oxidation | Weeks 0,12 | The effect of diet and exercise on carbohydrate and fat oxidation in response to meals and exercise as measured by whole-room calorimetry |
| Secondary | Food Cognitive Interference | Weeks 0, 12, 24 | The effect of diet and exercise on food cognitive interference, one of the three cognitive domains of executive function, using a computerized Food Stroop test. |
| Secondary | Cognitive flexibility | Weeks 0, 12, 24 | The effect of diet and exercise on cognitive flexibility, one of the three cognitive domains of executive function, using a computerized Trail-Making test B/A. |
| Secondary | Working memory | Weeks 0, 12, 24 | The effect of diet and exercise on cognitive flexibility, one of the three cognitive domains of executive function, using the Wisconsin Card Sorting Task. |
| Secondary | Inflammation | Weeks 0, 2, 4, 6, 8, 10, 12, 24 | The effect of diet and exercise on plasma pro-inflammatory cytokines (e.g., Il-6, MCP-1, TNF-alpha) and anti-inflammatory cytokines (e.g., IL-10, Soluble TNF receptor I and II) |
| Secondary | Change in adipokines | Weeks 0, 2, 4, 6, 8, 10, 12, 24 | The effect of diet and exercise on plasma adipokines (e.g., adiponectin, resistin) |
| Secondary | Change in myokines | Weeks 0, 2, 4, 6, 8, 10, 12, 24 | The effect of diet and exercise on plasma myokines (e.g., BDNF, Myostatin, FGF-21, Irisin) |
| Secondary | Change in bile acids | Weeks 0, 2, 4, 6, 8, 10, 12, 24 | The effect of diet and exercise on plasma bile acids (i.e., glycocholic acid, glyco-CDCA, glyco-HDCA, hyocholic acid, hyodeoxycholic acid) |
| Secondary | Change in blood lipids | Weeks 0, 2, 4, 6, 8, 10, 12, 24 | The effect of diet and exercise on cholesterol, HDL, triglycerides |
| Secondary | Change in weight control moderators | Weeks 0,12, 24 | Questionnaires (i.e., three-factor eating questionnaire, reward base eating, food attitudes and behavior survey) that when scored provide a single number will be used to determine the moderating effect of self efficacy, restraint and disinhibition maintaining diet and exercise changes |
| Secondary | Change in humoral biomarkers of eating behavior | Weeks 0, 2, 4, 6, 8, 10, 12, 24 | The effect of diet and exercise on ghrelin, leptin, thyroid hormones, gut peptides, fatty acids |
| Secondary | Gene expression profiles of glucose oxidation | Weeks 0, 2, 4, 6, 8, 10, 12, 24 | The effect of diet and exercise on gene expression profiles associated with glucose oxidation (i.e., hexokinase, phosphofructokinase, pyruvate dehydrogenase kinase 4, peroxisome proliferator-activated receptor alpha gene expression) |
| Secondary | Gene expression profiles of fat oxidation | Weeks 0, 2, 4, 6, 8, 10, 12, 24 | The effect of diet and exercise on on gene expression profiles associated with fat oxidation (i.e., fatty acid translocase, fatty acid synthase, acetyl Co-A carboxylase 2, stearoyl Co-A desaturase gene expression) |
| Other | Single nucleotide polymorphisms (SNP) | Weeks 0 | Correlation of SNPs associated with skeletal muscle, catecholamine, executive function and food and exercise reinforcement |
| Other | micro RNA (miRNA) | Weeks 0, 12, 24 | Correlation of miRNAs associated with skeletal muscle, executive function and food and exercise reinforcement |
Source ClinicalTrials.govtrials-2026-11-12-0.5.0
Sources 3
- ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
- ClinicalTrials.govNo license stated
- NIH RePORTER's clinical studies and project filesPublic domain
Each source's terms
- ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
- ClinicalTrials.govnone stated
- NIH RePORTER's clinical studies and project filesPublic domain (NIH RePORTER)
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.
For software
Read this list from software.
Twenty rows a page, as JSON. No key.
GET https://conductscience.org/api/trials/v1/NCT04577547/registered