Trial · NCT04581356
Voxelotor Sickle Cell Exercise Study
NCT04581356, Phase 4, Completed, Elizabeth Yang, MD, PhD
3 sourcestrials-2026-11-12-0.5.0
Cite this record
ConductScience Library. Voxelotor Sickle Cell Exercise Study. Trials, record NCT04581356. Release trials-2026-11-12-0.5.0, 12 Nov 2026. https://conductscience.org/library/trials/NCT04581356
On this page
Trial
As registered on ClinicalTrials.gov, in the graph's capture of the registry.
- Title
- Voxelotor Sickle Cell Exercise Study
- NCT number
- NCT04581356
- Status
- Completed
- Phases
- Phase 4
- Enrollment
- 14 participants, actual
- Lead sponsor
- Elizabeth Yang, MD, PhD
- Conditions
- Sickle Cell Anemia
- Interventions
- Voxelotor
- First posted
- 2020-10-09
- Last updated
- 2022-06-15
Source ClinicalTrials.gov
Registered outcomes12
Each outcome the trial registered, primary first, in ClinicalTrials.gov's words.
| List | Outcome | Time frame | Description |
|---|---|---|---|
| Primary | Peak oxygen consumption (VO2) | 8 weeks | Change in peak oxygen consumption (VO2) measured in CPET after voxelotor treatment |
| Secondary | Change in Biochemical markers of red cell sickling: Hemoglobin | 8 weeks | Measured before and after treatment with voxelotor. |
| Secondary | Change in Biochemical markers of red cell sickling: Reticulocyte Count | 8 weeks | Measured before and after treatment with voxelotor. |
| Secondary | Change in Biochemical markers of red cell sickling: Bilirubin | 8 weeks | Measured before and after treatment with voxelotor. |
| Secondary | Change in Biochemical markers of red cell sickling: Lactate Dehydrogenase (LDH) | 8 weeks | Measured before and after treatment with voxelotor. |
| Secondary | Change in Biochemical markers of red cell sickling: Haptoglobin | 8 weeks | Measured before and after treatment with voxelotor. |
| Secondary | Change in Biochemical markers of red cell sickling: % Fetal Hemoglobin expressing cells | 8 weeks | Measured before and after treatment with voxelotor. |
| Secondary | Change in Biochemical markers of red cell sickling: P50 oxygen dissociation | 8 weeks | Measured before and after treatment with voxelotor. |
| Secondary | Change in Biochemical markers of red cell sickling: Point of Sickling (POS) | 8 weeks | Measured before and after treatment with voxelotor. |
| Secondary | Change in Biochemical markers of red cell sickling: Dense Cells | 8 weeks | Measured before and after treatment with voxelotor. |
1 to 10 of 12Source ClinicalTrials.gov
See all 12 registered outcomesOutcomes0
Each outcome the trial posted results for, in ClinicalTrials.gov's words.
None in this release.
Results by group0
Each measurement the trial posted, group by group, in the words and numbers it posted.
None in this release.
Participant flow0
How many started, completed or left each group, period by period.
None in this release.
Adverse events0
Each adverse event the trial posted, group by group: the participants affected out of those at risk.
None in this release.
Adverse event totals0
The totals the trial posted for each group.
None in this release.
Papers1
The papers the trial lists on ClinicalTrials.gov.
| PMID | Listed as |
|---|---|
| 37247190 | DERIVED |
Source PubMed
Grants0
The grants NIH RePORTER links to the trial, newest funded first: NIH's, and some of AHRQ's, CDC's, FDA's and VA's. Each shows its title, principal investigators, organization and funder in its newest year.
None in this release.
Trial comparisons0
Comparisons of the trial's two groups, calculated by ConductScience from the counts it posted.
None in this release.
Tests0
The ConductCognition tests this trial's registered outcomes name, as ScienceGraph matched them in trial-tests-2026-11-12-0.2.1.
None in this release.
Data dates
The day each source was copied for this release.
Sources 3
- ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
- ClinicalTrials.govNo license stated
- NIH RePORTER's clinical studies and project filesPublic domain
Each source's terms
- ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
- ClinicalTrials.govnone stated
- NIH RePORTER's clinical studies and project filesPublic domain (NIH RePORTER)
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.
For software
Read this trial from software.
The record and each of its lists are JSON, twenty rows a page. No key.
GET https://conductscience.org/api/trials/v1/NCT04581356
GET https://conductscience.org/api/trials/v1/NCT04581356/registered