Trial · NCT04581395
The Effect of Pretreatment With Roc on Succinylcholine Myalgias
NCT04581395, Phase 3, Completed, Indiana University; results first posted 2024-05-16
3 sourcestrials-2026-11-12-0.5.0
Cite this record
ConductScience Library. The Effect of Pretreatment With Roc on Succinylcholine Myalgias. Trials, record NCT04581395. Release trials-2026-11-12-0.5.0, 12 Nov 2026. https://conductscience.org/library/trials/NCT04581395
On this page
Trial
As registered on ClinicalTrials.gov, in the graph's capture of the registry.
- Title
- The Effect of Pretreatment With Roc on Succinylcholine Myalgias
- NCT number
- NCT04581395
- Status
- Completed
- Phases
- Phase 3
- Enrollment
- 300 participants, actual
- Lead sponsor
- Indiana University
- Conditions
- Myalgia
- Interventions
- non-pretreated Succinylcholine, succinylcholine 1 minute after rocuronium pretreatment, succinylcholine 2 minutes following rocuronium pretreatment
- First posted
- 2020-10-09
- Last updated
- 2024-08-21
- Results first posted
- 2024-05-16
Source ClinicalTrials.gov
Registered outcomes5
Each outcome the trial registered, primary first, in ClinicalTrials.gov's words.
| List | Outcome | Time frame | Description |
|---|---|---|---|
| Primary | Myalgias Perceived at 3 Hours | 3 hours post succinylcholine administration | The data are reported as pain (scores 1-4) vs. no pain (score 0). |
| Primary | Myalgias at 24 Hours Post Succinylcholine Administration. | 24 hours post succinylcholine administration | The presence of myalgias referencing a severity scale from 0 (no muscle pain), 1 (mild muscle pain), 2(moderate muscle pain), 3 (Moderate muscle pain) and 4 (Severe muscle pain). The data are reported as pain (scores 1-4) vs. no pain (score 0) |
| Primary | Pain Scores | 3 hours post succinylcholine administration | 0=no muscle pain/stiffness, 1=mild muscle pain/stiffness not limiting daily activity, 2=moderate muscle pain/stiffness not limiting daily activity, 3=moderate muscle pain stiffness that limits daily activity, 4=severe muscle pain/stiffness limiting movement and preventing daily activity. Values averaged. |
| Primary | Pain Scores | 24 hours post succinylcholine administration. | 0=no muscle pain/stiffness, 1=mild muscle pain/stiffness not limiting daily activity, 2=moderate muscle pain/stiffness not limiting daily activity, 3=moderate muscle pain stiffness that limits daily activity, 4=severe muscle pain/stiffness limiting movement and preventing daily activity. Values averaged. |
| Secondary | Number of Participants With Observed Presence of Muscle Fasciculation Following Succinylcholine Administration | immediately following succinylcholine administration up to 2 minutes | Observed presence or absence of muscle fasciculation following succinylcholine administration in subjects pretreated with rocuronium 1 minute prior to succinylcholine administration or 2 minutes prior to succinylcholine administration compared to the control group not pretreated with rocuronium. |
Source ClinicalTrials.gov
Outcomes5
Each outcome the trial posted results for, in ClinicalTrials.gov's words.
| Type | Outcome | Time frame | Population | Units | Measured as |
|---|---|---|---|---|---|
| PRIMARY | Myalgias Perceived at 3 Hours | 3 hours post succinylcholine administration | Participants | COUNT_OF_PARTICIPANTS | |
| PRIMARY | Myalgias at 24 Hours Post Succinylcholine Administration. | 24 hours post succinylcholine administration | Participants | COUNT_OF_PARTICIPANTS | |
| PRIMARY | Pain Scores | 3 hours post succinylcholine administration | Participants | COUNT_OF_PARTICIPANTS | |
| PRIMARY | Pain Scores | 24 hours post succinylcholine administration. | Participants | COUNT_OF_PARTICIPANTS | |
| SECONDARY | Number of Participants With Observed Presence of Muscle Fasciculation Following Succinylcholine Administration | immediately following succinylcholine administration up to 2 minutes | Participants | COUNT_OF_PARTICIPANTS |
Source ClinicalTrials.gov
Results by group45
Each measurement the trial posted, group by group, in the words and numbers it posted.
| Outcome | Group | Category | Value | Spread | Units |
|---|---|---|---|---|---|
| Myalgias Perceived at 3 Hours | Not Pretreated With Rocuronium | Patients with no pain 3 hours post succinylcholine | 81 | Participants | |
| Myalgias Perceived at 3 Hours | Pre-treated With Rocuronium 1 Minute Before Succinylcholine Administration | Patients with no pain 3 hours post succinylcholine | 83 | Participants | |
| Myalgias Perceived at 3 Hours | Pre-treated With Rocuronium 2 Minutes Before Succinylcholine Administratjion | Patients with no pain 3 hours post succinylcholine | 83 | Participants | |
| Myalgias Perceived at 3 Hours | Not Pretreated With Rocuronium | Patients who described having pain 3 hours post succinylcholine | 15 | Participants | |
| Myalgias Perceived at 3 Hours | Pre-treated With Rocuronium 1 Minute Before Succinylcholine Administration | Patients who described having pain 3 hours post succinylcholine | 13 | Participants | |
| Myalgias Perceived at 3 Hours | Pre-treated With Rocuronium 2 Minutes Before Succinylcholine Administratjion | Patients who described having pain 3 hours post succinylcholine | 15 | Participants | |
| Myalgias at 24 Hours Post Succinylcholine Administration. | Not Pretreated With Rocuronium | patients experiencing no pain 24 hours post succinylcholine administrations | 64 | Participants | |
| Myalgias at 24 Hours Post Succinylcholine Administration. | Pre-treated With Rocuronium 1 Minute Before Succinylcholine Administration | patients experiencing no pain 24 hours post succinylcholine administrations | 78 | Participants | |
| Myalgias at 24 Hours Post Succinylcholine Administration. | Pre-treated With Rocuronium 2 Minutes Before Succinylcholine Administratjion | patients experiencing no pain 24 hours post succinylcholine administrations | 80 | Participants | |
| Myalgias at 24 Hours Post Succinylcholine Administration. | Not Pretreated With Rocuronium | Patients experiencing pain at 24 hours post succinylcholine administrations | 32 | Participants |
1 to 10 of 45Source ClinicalTrials.gov
See all 45 results by groupParticipant flow9
How many started, completed or left each group, period by period.
| Period | Milestone | Group | Participants | Units counted |
|---|---|---|---|---|
| Overall Study | STARTED | Not Pretreated With Rocuronium | 100 | |
| Overall Study | STARTED | Pre-treated With Rocuronium 1 Minute Before Succinylcholine Administration | 100 | |
| Overall Study | STARTED | Pre-treated With Rocuronium 2 Minutes Before Succinylcholine Administratjion | 100 | |
| Overall Study | COMPLETED | Not Pretreated With Rocuronium | 96 | |
| Overall Study | COMPLETED | Pre-treated With Rocuronium 1 Minute Before Succinylcholine Administration | 96 | |
| Overall Study | COMPLETED | Pre-treated With Rocuronium 2 Minutes Before Succinylcholine Administratjion | 98 | |
| Overall Study | NOT COMPLETED | Not Pretreated With Rocuronium | 4 | |
| Overall Study | NOT COMPLETED | Pre-treated With Rocuronium 1 Minute Before Succinylcholine Administration | 4 | |
| Overall Study | NOT COMPLETED | Pre-treated With Rocuronium 2 Minutes Before Succinylcholine Administratjion | 2 |
Source ClinicalTrials.gov
Adverse events0
Each adverse event the trial posted, group by group: the participants affected out of those at risk.
None in this release.
Adverse event totals9
The totals the trial posted for each group.
| Total | Group | Affected | At risk |
|---|---|---|---|
| Total, all-cause mortality | Not Pretreated With Rocuronium | 0 | 100 |
| Total, all-cause mortality | Pre-treated With Rocuronium 1 Minute Before Succinylcholine Administration | 0 | 100 |
| Total, all-cause mortality | Pre-treated With Rocuronium 2 Minutes Before Succinylcholine Administratjion | 0 | 100 |
| Total, other adverse events | Not Pretreated With Rocuronium | 0 | 100 |
| Total, other adverse events | Pre-treated With Rocuronium 1 Minute Before Succinylcholine Administration | 0 | 100 |
| Total, other adverse events | Pre-treated With Rocuronium 2 Minutes Before Succinylcholine Administratjion | 0 | 100 |
| Total, serious adverse events | Not Pretreated With Rocuronium | 0 | 100 |
| Total, serious adverse events | Pre-treated With Rocuronium 1 Minute Before Succinylcholine Administration | 0 | 100 |
| Total, serious adverse events | Pre-treated With Rocuronium 2 Minutes Before Succinylcholine Administratjion | 0 | 100 |
Source ClinicalTrials.gov
Papers8
The papers the trial lists on ClinicalTrials.gov.
Grants0
The grants NIH RePORTER links to the trial, newest funded first: NIH's, and some of AHRQ's, CDC's, FDA's and VA's. Each shows its title, principal investigators, organization and funder in its newest year.
None in this release.
Trial comparisons0
Comparisons of the trial's two groups, calculated by ConductScience from the counts it posted.
None in this release.
Tests0
The ConductCognition tests this trial's registered outcomes name, as ScienceGraph matched them in trial-tests-2026-11-12-0.2.1.
None in this release.
Data dates
The day each source was copied for this release.
Sources 3
- ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
- ClinicalTrials.govNo license stated
- NIH RePORTER's clinical studies and project filesPublic domain
Each source's terms
- ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
- ClinicalTrials.govnone stated
- NIH RePORTER's clinical studies and project filesPublic domain (NIH RePORTER)
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.
For software
Read this trial from software.
The record and each of its lists are JSON, twenty rows a page. No key.
GET https://conductscience.org/api/trials/v1/NCT04581395
GET https://conductscience.org/api/trials/v1/NCT04581395/results?page=2