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Trial · NCT04588792

Registered outcomes11

Each outcome the trial registered, primary first, in ClinicalTrials.gov's words.

ListOutcomeTime frameDescription
PrimaryImprovement in pulmonary gas exchangeStudy Day 6Improvement in oxygenation as determined by a standardized PaO2/FiO2 ratio
PrimaryRequirement for mechanical ventilationBaseline to day 28Number of ventilator-free days in the first 28 days after enrollment
SecondaryMortalityDay 60 post enrollmentAll Cause
SecondaryRequirement for supplemental oxygenTo day 28 post enrollmentNumber of days of alive and not requiring supplemental oxygen
SecondaryDuration of ICU StayUp to 60 days post enrollmentDuration of ICU Stay
SecondaryLength of hospitalizationUp to 60 days post enrollmentLength of hospitalization
SecondaryAdverse eventsUp to 60 days post enrollmentIncidence of serious adverse events: incorporated as trial outcomes, defined a priori, in accordance with guidelines for academic ICU drug trials
SecondaryInhalation adverse eventsUp to day 28Adverse events during the nebulization of furosemide
OtherSerum levels of furosemideUp to day 28Serum levels of furosemide every 7 days until the completion of therapy
OtherElectrolyte abnormalitiesUp to day 28Altered electrolytes on routine testing (frequency of hypokalemia (\< 3.0 meq/L), hypernatremia (\> 150 meq/L) or increased bicarbonate levels (\>30 meq/L) during the ICU stay
OtherCytokine levelsUp to day 28Levels of serum inflammatory cytokines (IL-6, IL-8, TNF-α) at baseline prior to first dose of intervention, day 7, and the completion of therapy

Source ClinicalTrials.govtrials-2026-11-12-0.5.0

Sources 3

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ClinicalTrials.govNo license stated
  • NIH RePORTER's clinical studies and project filesPublic domain
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ClinicalTrials.govnone stated
  • NIH RePORTER's clinical studies and project filesPublic domain (NIH RePORTER)

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

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