Trial · NCT04594369
Results by group91
Each measurement the trial posted, group by group, in the words and numbers it posted.
1 to 20 of 91
Download this page as JSON| Outcome | Group | Category | Value | Spread | Units |
|---|---|---|---|---|---|
| Annualized Rate of Pulmonary Exacerbations (PEs) | Brensocatib 10 mg | 1.015 | 95% Confidence Interval 0.910 to 1.132 | exacerbation per participant-year | |
| Annualized Rate of Pulmonary Exacerbations (PEs) | Brensocatib 25 mg | 1.036 | 95% Confidence Interval 0.927 to 1.157 | exacerbation per participant-year | |
| Annualized Rate of Pulmonary Exacerbations (PEs) | Placebo | 1.286 | 95% Confidence Interval 1.158 to 1.428 | exacerbation per participant-year | |
| Time to First PE | Brensocatib 10 mg | 49.000 | 95% Confidence Interval 40.000 to NA | weeks | |
| Time to First PE | Brensocatib 25 mg | 50.714 | 95% Confidence Interval 37.571 to NA | weeks | |
| Time to First PE | Placebo | 36.714 | 95% Confidence Interval 31.143 to 41.429 | weeks | |
| Responder Status for Exacerbation-Free Over the 52-Week Treatment Period | Brensocatib 10 mg | 48.5 | percentage of participants | ||
| Responder Status for Exacerbation-Free Over the 52-Week Treatment Period | Brensocatib 25 mg | 48.5 | percentage of participants | ||
| Responder Status for Exacerbation-Free Over the 52-Week Treatment Period | Placebo | 40.3 | percentage of participants | ||
| Change From Baseline at Week 52 in Postbronchodilator Forced Expiratory Volume in 1 Second (FEV1) | Brensocatib 10 mg | -0.050 | Standard Error 0.0093 | liter (L) | |
| Change From Baseline at Week 52 in Postbronchodilator Forced Expiratory Volume in 1 Second (FEV1) | Brensocatib 25 mg | -0.024 | Standard Error 0.0099 | liter (L) | |
| Change From Baseline at Week 52 in Postbronchodilator Forced Expiratory Volume in 1 Second (FEV1) | Placebo | -0.062 | Standard Error 0.0094 | liter (L) | |
| Annualized Rate of Severe PEs | Brensocatib 10 mg | 0.137 | 95% Confidence Interval 0.103 to 0.182 | exacerbation per participant-year | |
| Annualized Rate of Severe PEs | Brensocatib 25 mg | 0.137 | 95% Confidence Interval 0.105 to 0.179 | exacerbation per participant-year | |
| Annualized Rate of Severe PEs | Placebo | 0.185 | 95% Confidence Interval 0.142 to 0.242 | exacerbation per participant-year | |
| Change From Baseline at Week 52 in Quality of Life Questionnaire - Bronchiectasis (QOL-B) Respiratory Symptoms Domain Score in Adult Participants | Brensocatib 10 mg | 6.841 | Standard Error 0.7706 | score on scale | |
| Change From Baseline at Week 52 in Quality of Life Questionnaire - Bronchiectasis (QOL-B) Respiratory Symptoms Domain Score in Adult Participants | Brensocatib 25 mg | 8.575 | Standard Error 0.7556 | score on scale | |
| Change From Baseline at Week 52 in Quality of Life Questionnaire - Bronchiectasis (QOL-B) Respiratory Symptoms Domain Score in Adult Participants | Placebo | 4.809 | Standard Error 0.7500 | score on scale | |
| Number of Participants Who Experienced at Least One Treatment-Emergent Adverse Events (TEAEs) | Brensocatib 10 mg | 452 | Participants | ||
| Number of Participants Who Experienced at Least One Treatment-Emergent Adverse Events (TEAEs) | Brensocatib 25 mg | 440 | Participants |
Source ClinicalTrials.govtrials-2026-11-12-0.5.0
Sources 3
- ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
- ClinicalTrials.govNo license stated
- NIH RePORTER's clinical studies and project filesPublic domain
Each source's terms
- ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
- ClinicalTrials.govnone stated
- NIH RePORTER's clinical studies and project filesPublic domain (NIH RePORTER)
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.
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GET https://conductscience.org/api/trials/v1/NCT04594369/results