Trial · NCT04601961
Effects of TIVA Versus Inhalational Anaesthesia on Circulating Tumour Cells in Hepatocellular Carcinoma Patients
NCT04601961, Not applicable, Unknown, The University of Hong Kong
3 sourcestrials-2026-11-12-0.5.0
Cite this record
ConductScience Library. Effects of TIVA Versus Inhalational Anaesthesia on Circulating Tumour Cells in Hepatocellular Carcinoma Patients. Trials, record NCT04601961. Release trials-2026-11-12-0.5.0, 12 Nov 2026. https://conductscience.org/library/trials/NCT04601961
On this page
Trial
As registered on ClinicalTrials.gov, in the graph's capture of the registry.
- Title
- Effects of TIVA Versus Inhalational Anaesthesia on Circulating Tumour Cells in Hepatocellular Carcinoma Patients
- NCT number
- NCT04601961
- Status
- Unknown
- Phases
- Not applicable
- Enrollment
- 220 participants, estimated
- Lead sponsor
- The University of Hong Kong
- Conditions
- Circulating Tumor Cell, Hepatocellular Carcinoma
- Interventions
- Propofol, Sevoflurane
- First posted
- 2020-10-26
- Last updated
- 2023-03-31
Source ClinicalTrials.gov
Registered outcomes10
Each outcome the trial registered, primary first, in ClinicalTrials.gov's words.
| List | Outcome | Time frame | Description |
|---|---|---|---|
| Primary | HIF-1 gene expression | 24 hour | the detection of a two-fold difference between the pre-operative blood sample and 24-hour post-operative blood sample in HIF-1 gene expression in the SEVO group, and a less than two-fold difference in the same samples of the TIVA group |
| Secondary | Change in number of recurrence | 2 year | Change in the incidence of two-year recurrence between TIVA and SEVO group |
| Secondary | Level of Gene expression | Pre-operative, Intra-operative, Immediately post-operative and 24 hours post-surgery | The level of Gene expression (HIF-1, IL-6, TNF-alpha) will be measured from the RNA/cDNA extracted from blood sample taken at different timepoints by Polymerase chain reaction test |
| Secondary | Level of DNA damage | Pre-operative, Intra-operative, Immediately post-operative and 24 hours post-surgery | The level of DNA damage will be measured from the white blood cells extracted from blood sample taken at different timepoints by Comet Assay test |
| Secondary | Level of C-reactive protein | Pre-operative, Intra-operative, Immediately post-operative and 24 hours post-surgery | The level of C-reactive protein will be measured from the Plasma extracted from blood sample taken at different timepoints by Commercial Kit |
| Secondary | Level of Glutathione Peroxidase | Pre-operative, Intra-operative, Immediately post-operative and 24 hours post-surgery | The level of Glutathione Peroxidase will be measured from the Red blood cells extracted from blood sample taken at different timepoints by Commercial Kit |
| Secondary | Level of Superoxide dismutase | Pre-operative, Intra-operative, Immediately post-operative and 24 hours post-surgery | The level of Superoxide dismutase will be measured from the Red blood cells extracted from blood sample taken at different timepoints by Commercial Kit |
| Secondary | Level of Oxidative damage DNA | Pre-operative, Intra-operative, Immediately post-operative and 24 hours post-surgery | The level of Oxidative damage DNA (8-oxoGuo, 8-oxodG) will be measured from the Plasma extracted by Commercial Kit |
| Secondary | Level of tumor necrosis factor | Pre-operative, Intra-operative, Immediately post-operative and 24 hours post-surgery | The level of tumor necrosis factor (IL-6, TNF-alpha, HIF-1) will be measured from the Plasma extracted by An enzyme-linked immunosorbent assay (ELISA) |
| Secondary | Number of Circulating tumour cells | Pre-operative, Intra-operative, Immediately post-operative and 24 hours post-surgery | The number of Circulating tumour cells will be isolated from the blood samples taken at different timepoints by filtration and count under microscope |
Source ClinicalTrials.gov
Outcomes0
Each outcome the trial posted results for, in ClinicalTrials.gov's words.
None in this release.
Results by group0
Each measurement the trial posted, group by group, in the words and numbers it posted.
None in this release.
Participant flow0
How many started, completed or left each group, period by period.
None in this release.
Adverse events0
Each adverse event the trial posted, group by group: the participants affected out of those at risk.
None in this release.
Adverse event totals0
The totals the trial posted for each group.
None in this release.
Papers0
The papers the trial lists on ClinicalTrials.gov.
None in this release.
Grants0
The grants NIH RePORTER links to the trial, newest funded first: NIH's, and some of AHRQ's, CDC's, FDA's and VA's. Each shows its title, principal investigators, organization and funder in its newest year.
None in this release.
Trial comparisons0
Comparisons of the trial's two groups, calculated by ConductScience from the counts it posted.
None in this release.
Tests0
The ConductCognition tests this trial's registered outcomes name, as ScienceGraph matched them in trial-tests-2026-11-12-0.2.1.
None in this release.
Data dates
The day each source was copied for this release.
Sources 3
- ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
- ClinicalTrials.govNo license stated
- NIH RePORTER's clinical studies and project filesPublic domain
Each source's terms
- ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
- ClinicalTrials.govnone stated
- NIH RePORTER's clinical studies and project filesPublic domain (NIH RePORTER)
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.
For software
Read this trial from software.
The record and each of its lists are JSON, twenty rows a page. No key.
GET https://conductscience.org/api/trials/v1/NCT04601961
GET https://conductscience.org/api/trials/v1/NCT04601961/registered