Trial · NCT04611347
Is Topical CBD Effective in Treating Thumb Joint Arthritis
NCT04611347, Phase 2, Completed, University of Virginia; results first posted 2025-07-03
3 sourcestrials-2026-11-12-0.5.0
Cite this record
ConductScience Library. Is Topical CBD Effective in Treating Thumb Joint Arthritis. Trials, record NCT04611347. Release trials-2026-11-12-0.5.0, 12 Nov 2026. https://conductscience.org/library/trials/NCT04611347
On this page
Trial
As registered on ClinicalTrials.gov, in the graph's capture of the registry.
- Title
- Is Topical CBD Effective in Treating Thumb Joint Arthritis
- NCT number
- NCT04611347
- Status
- Completed
- Phases
- Phase 2
- Enrollment
- 18 participants, actual
- Lead sponsor
- University of Virginia
- Conditions
- CBD, Hand Osteoarthritis
- Interventions
- CBD, Shea Butter
- First posted
- 2020-11-02
- Last updated
- 2025-07-03
- Results first posted
- 2025-07-03
Source ClinicalTrials.gov
Registered outcomes5
Each outcome the trial registered, primary first, in ClinicalTrials.gov's words.
| List | Outcome | Time frame | Description |
|---|---|---|---|
| Primary | Change in Hand Strength During Intervention and at Follow-up. | Change from baseline to 2 weeks | Grip strength, kg. |
| Primary | Change in the PROMIS Upper Extremity Tests During Intervention and at Follow-up. | Change from baseline to 2 weeks | The Patient Reported Outcome Information System (PROMIS) Upper Extremity Computer Adaptive Test (CAT) is a computerized assessment measuring the physical function of the upper extremity. It is scored using a T-score, and the average is 50 for the U.S. population. In a given PROMIS, a T-score above 50 represents more of the measured variable than the average. For this variable, a T-score above 50 indicates greater physical function than the average population. |
| Primary | Change in Kapandji Score | Change from baseline to 2 weeks | Kapandji score (ranging 0 to 10) is validated measures in past studies as outcomes for hand disability. The Kapandji score is a tool useful for assessing the opposition of the thumb, based on where on their hand the patient is able to touch with the tip of their thumb. A score of 0 indicates no opposition, a score of 10 indicates maximal opposition. |
| Primary | Change in Hand Range of Motion | Change from baseline to 2 weeks | Metacarpal phalangeal (MP) range of motion, passive extension. |
| Secondary | Rate of Side Effects Using Novel CBD Cream. | Change from baseline to 2 weeks | Side effects will be assessed at each encounter clinical evaluation by patient report in a Symptom Diary. All side effects thought to be secondary to CBD will be documented. |
Source ClinicalTrials.gov
Outcomes5
Each outcome the trial posted results for, in ClinicalTrials.gov's words.
| Type | Outcome | Time frame | Population | Units | Measured as |
|---|---|---|---|---|---|
| PRIMARY | Change in Hand Strength During Intervention and at Follow-up. | Change from baseline to 2 weeks | Subjects served as their own control so 18 people completed each intervention. | KG | MEAN |
| PRIMARY | Change in the PROMIS Upper Extremity Tests During Intervention and at Follow-up. | Change from baseline to 2 weeks | Subjects served as their own control so 18 people completed each intervention. | score on a survey | MEAN |
| PRIMARY | Change in Kapandji Score | Change from baseline to 2 weeks | Subjects served as their own control so 18 people completed each intervention. | score on a scale | MEAN |
| PRIMARY | Change in Hand Range of Motion | Change from baseline to 2 weeks | Subjects served as their own control so 18 people completed each intervention. | degrees | MEAN |
| SECONDARY | Rate of Side Effects Using Novel CBD Cream. | Change from baseline to 2 weeks | Subjects served as their own control so 18 people completed each intervention. | Participants | COUNT_OF_PARTICIPANTS |
Source ClinicalTrials.gov
Results by group10
Each measurement the trial posted, group by group, in the words and numbers it posted.
| Outcome | Group | Category | Value | Spread | Units |
|---|---|---|---|---|---|
| Change in Hand Strength During Intervention and at Follow-up. | CBD Group | 24 | Standard Deviation 2.3 | KG | |
| Change in Hand Strength During Intervention and at Follow-up. | Shea Butter Group | 23 | Standard Deviation 2.8 | KG | |
| Change in the PROMIS Upper Extremity Tests During Intervention and at Follow-up. | CBD Group | 4.2 | Standard Deviation 1.8 | score on a survey | |
| Change in the PROMIS Upper Extremity Tests During Intervention and at Follow-up. | Shea Butter Group | 38 | Standard Deviation 1.5 | score on a survey | |
| Change in Kapandji Score | CBD Group | 9 | Standard Deviation 0.2 | score on a scale | |
| Change in Kapandji Score | Shea Butter Group | 9 | Standard Deviation 0.4 | score on a scale | |
| Change in Hand Range of Motion | CBD Group | -7.5 | Standard Deviation 3.9 | degrees | |
| Change in Hand Range of Motion | Shea Butter Group | -3 | Standard Deviation 4.2 | degrees | |
| Rate of Side Effects Using Novel CBD Cream. | CBD Group | 0 | Participants | ||
| Rate of Side Effects Using Novel CBD Cream. | Shea Butter Group | 0 | Participants |
Source ClinicalTrials.gov
Participant flow6
How many started, completed or left each group, period by period.
| Period | Milestone | Group | Participants | Units counted |
|---|---|---|---|---|
| Overall Study | STARTED | First CBD, Then Shea Butter | 10 | |
| Overall Study | STARTED | First Shea Butter, the CBD | 8 | |
| Overall Study | COMPLETED | First CBD, Then Shea Butter | 10 | |
| Overall Study | COMPLETED | First Shea Butter, the CBD | 8 | |
| Overall Study | NOT COMPLETED | First CBD, Then Shea Butter | 0 | |
| Overall Study | NOT COMPLETED | First Shea Butter, the CBD | 0 |
Source ClinicalTrials.gov
Adverse events0
Each adverse event the trial posted, group by group: the participants affected out of those at risk.
None in this release.
Adverse event totals6
The totals the trial posted for each group.
| Total | Group | Affected | At risk |
|---|---|---|---|
| Total, all-cause mortality | CBD Intervention | 0 | 18 |
| Total, all-cause mortality | Shea Butter Intervention | 0 | 18 |
| Total, other adverse events | CBD Intervention | 0 | 18 |
| Total, other adverse events | Shea Butter Intervention | 0 | 18 |
| Total, serious adverse events | CBD Intervention | 0 | 18 |
| Total, serious adverse events | Shea Butter Intervention | 0 | 18 |
Source ClinicalTrials.gov
Papers0
The papers the trial lists on ClinicalTrials.gov.
None in this release.
Grants0
The grants NIH RePORTER links to the trial, newest funded first: NIH's, and some of AHRQ's, CDC's, FDA's and VA's. Each shows its title, principal investigators, organization and funder in its newest year.
None in this release.
Trial comparisons3
Comparisons of the trial's two groups, calculated by ConductScience from the counts it posted.
| Comparison | Source |
|---|---|
| CBD Group vs Shea Butter Group: Rate of Side Effects Using Novel CBD Cream. | Trial comparisons |
| CBD Intervention vs Shea Butter Intervention: deaths from any cause | Trial comparisons |
| CBD Intervention vs Shea Butter Intervention: serious adverse events | Trial comparisons |
Tests0
The ConductCognition tests this trial's registered outcomes name, as ScienceGraph matched them in trial-tests-2026-11-12-0.2.1.
None in this release.
Data dates
The day each source was copied for this release.
Sources 3
- ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
- ClinicalTrials.govNo license stated
- NIH RePORTER's clinical studies and project filesPublic domain
Each source's terms
- ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
- ClinicalTrials.govnone stated
- NIH RePORTER's clinical studies and project filesPublic domain (NIH RePORTER)
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.
For software
Read this trial from software.
The record and each of its lists are JSON, twenty rows a page. No key.
GET https://conductscience.org/api/trials/v1/NCT04611347
GET https://conductscience.org/api/trials/v1/NCT04611347/registered