Trial · NCT04638517
The TELO-SCOPE Study: Attenuating Telomere Attrition With Danazol. Is There Scope to Dramatically Improve Health Outcomes for Adults and Children With Pulmonary Fibrosis
NCT04638517, Phase 2, Terminated, The University of Queensland
3 sourcestrials-2026-11-12-0.5.0
Cite this record
ConductScience Library. The TELO-SCOPE Study: Attenuating Telomere Attrition With Danazol. Is There Scope to Dramatically Improve Health Outcomes for Adults and Children With Pulmonary Fibrosis. Trials, record NCT04638517. Release trials-2026-11-12-0.5.0, 12 Nov 2026. https://conductscience.org/library/trials/NCT04638517
On this page
Trial
As registered on ClinicalTrials.gov, in the graph's capture of the registry.
- Title
- The TELO-SCOPE Study: Attenuating Telomere Attrition With Danazol. Is There Scope to Dramatically Improve Health Outcomes for Adults and Children With Pulmonary Fibrosis
- NCT number
- NCT04638517
- Status
- Terminated
- Phases
- Phase 2
- Enrollment
- 29 participants, actual
- Lead sponsor
- The University of Queensland
- Conditions
- Pulmonary Fibrosis, Telomere Shortening, Telomere Disease, Dyskeratosis Congenita
- Interventions
- Danazol, Placebo
- First posted
- 2020-11-20
- Last updated
- 2025-08-05
Source ClinicalTrials.gov
Registered outcomes10
Each outcome the trial registered, primary first, in ClinicalTrials.gov's words.
| List | Outcome | Time frame | Description |
|---|---|---|---|
| Primary | Change in absolute telomere length from baseline (base pairs) | 12 months | Telomere length will be measured in absolute terms (base pairs) using the telomere shortest length assay (TeSLA). |
| Secondary | Number of participants with treatment-emergent adverse events | 12 months | |
| Secondary | Number of Participants With Death or Non-Elective Hospitalisation | 12 months | |
| Secondary | Change in telomere length from baseline to 3, 6 and 9 months (base pairs) | 3, 6 and 9 months | |
| Secondary | Change in forced vital capacity (FVC) at 6 and 12 months | 6 and 12 months | FVC is measured as the volume of air exhaled during spirometry. |
| Secondary | Change in diffusing capacity for carbon monoxide at 6 and 12 months | 6 and 12 months | DLCO is a measurement of the of the lung's gas transfer ability. |
| Secondary | Change in 6-minute walk distance from baseline | 12 months | |
| Secondary | Change in Leicester cough questionnaire (LCQ) from baseline | 12 months | |
| Secondary | Change in King's Brief Interstitial Lung Disease Questionnaire (K-BILD) from baseline | 12 months | |
| Secondary | Change in Parent cough-specific quality of life (PCSQoL) from baseline | 12 months |
Source ClinicalTrials.gov
Outcomes0
Each outcome the trial posted results for, in ClinicalTrials.gov's words.
None in this release.
Results by group0
Each measurement the trial posted, group by group, in the words and numbers it posted.
None in this release.
Participant flow0
How many started, completed or left each group, period by period.
None in this release.
Adverse events0
Each adverse event the trial posted, group by group: the participants affected out of those at risk.
None in this release.
Adverse event totals0
The totals the trial posted for each group.
None in this release.
Papers1
The papers the trial lists on ClinicalTrials.gov.
| PMID | Listed as |
|---|---|
| 34857525 | DERIVED |
Source PubMed
Grants0
The grants NIH RePORTER links to the trial, newest funded first: NIH's, and some of AHRQ's, CDC's, FDA's and VA's. Each shows its title, principal investigators, organization and funder in its newest year.
None in this release.
Trial comparisons0
Comparisons of the trial's two groups, calculated by ConductScience from the counts it posted.
None in this release.
Tests0
The ConductCognition tests this trial's registered outcomes name, as ScienceGraph matched them in trial-tests-2026-11-12-0.2.1.
None in this release.
Data dates
The day each source was copied for this release.
Sources 3
- ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
- ClinicalTrials.govNo license stated
- NIH RePORTER's clinical studies and project filesPublic domain
Each source's terms
- ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
- ClinicalTrials.govnone stated
- NIH RePORTER's clinical studies and project filesPublic domain (NIH RePORTER)
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.
For software
Read this trial from software.
The record and each of its lists are JSON, twenty rows a page. No key.
GET https://conductscience.org/api/trials/v1/NCT04638517
GET https://conductscience.org/api/trials/v1/NCT04638517/registered