Trial · NCT04679051

Long Sleep Duration and Vascular Function

NCT04679051, Not applicable, Completed, Texas Tech University; results first posted 2023-01-12

3 sourcestrials-2026-11-12-0.5.0

Cite this record

ConductScience Library. Long Sleep Duration and Vascular Function. Trials, record NCT04679051. Release trials-2026-11-12-0.5.0, 12 Nov 2026. https://conductscience.org/library/trials/NCT04679051

On this page

Trial

As registered on ClinicalTrials.gov, in the graph's capture of the registry.

Title: Long Sleep Duration and Vascular Function
NCT number: NCT04679051
Status: Completed
Phases: Not applicable
Enrollment: 23 participants, actual
Lead sponsor: Texas Tech University
Conditions: Sleep
Interventions: Sleep duration
First posted: 2020-12-22
Last updated: 2023-01-13
Results first posted: 2023-01-12

Source ClinicalTrials.gov

Registered outcomes7

Each outcome the trial registered, primary first, in ClinicalTrials.gov's words.

List	Outcome	Time frame	Description
Primary	Change From Wake in Central Aortic Pulse Pressure After 11 Hours in Bed	One night during each time in bed condition	Central aortic pulse pressure was measured one night during the week of 8 hours in bed, then again one night during the week of 11 hours in bed. Blood pressure was measured using an Oscar2 ambulatory blood pressure device. The device started recordings one hour prior to sleep and was programmed to take measurements once every 30 minutes during sleep until 10:00pm then every 45 minutes after 10:00pm until participants arose from bed. The change in central aortic pulse pressure from being awake to being asleep was compared between 8 and 11 hours in bed conditions.
Primary	Change in Cerebral Vascular Reactivity After 11 Hours in Bed	Morning after one week of 8 and 11 hours in bed	Blood flow measured in the middle cerebral artery during hypercapnia was measured after one week of 8 hours in bed, then again after one week of 11 hours in bed. Cerebral blood flow was measured using transcranial Doppler during 3 minutes of transient hypercapnia induced by rebreathing. Cerebral vascular reactivity was considered as the percent increase in cerebral blood flow at the end of 3 minutes of rebreathing relative to the Torr change in end-tidal carbon dioxide (percent change/Torr).
Primary	Change in Peak Reactive Hyperemia After 11 Hours in Bed	Morning after one week of 8 and 11 hours in bed	Peak forearm blood flow was measured after one week of 8 hours in bed, then again after one week of 11 hours in bed. Peak reactive hyperemia in the forearm (ml/100ml/min) was measured using venous occlusion plethysmography after 10 minutes of forearm ischemia resulting from blood pressure cuff inflation at the upper-arm. Peak blood flow was considered the highest blood flow measurement after the blood pressure cuff was deflated.
Primary	Change in Arterial Stiffness After 11 Hours in Bed	Morning after one week of 8 and 11 hours in bed	Arterial stiffness was measured after one week of 8 hours in bed, then again after one week of 11 hours in bed. Carotid-femoral pulse wave velocity was used as the measure of arterial stiffness. Radial arterial tonometry was used to derive a central aortic blood pressure wave. Wave separation analysis of the aortic pressure wave was then used to calculate pulse wave velocity from transit time and carotid-femoral path length.
Secondary	Change in Spatial Orientation After Aerobic Exercise	Baseline and after exercise	Score from a Manikin test of spatial orientation that participants took using a computer with automated software (Automated Neuropsychological Assessment Metrics, known as ANAM). Scores reflect "throughput scores" which is a continuous variable that is the ratio of correct answers per minute during the Manikin test. Higher throughput scores mean better outcome, in this case, better spatial orientation ability. Participants took the Manikin test after one week of 8 and 11 hours in bed (i.e., baseline) then the morning after one day of aerobic exercise. Exercise consisted of three sessions of 10 minutes brisk walking at a heart rate considered to be moderate intensity (50-70% of age-predicted maximal heart rate). Results reported reflect the change in throughput scores after exercise (morning after exercise minus baseline).
Secondary	Change in Executive Function After Aerobic Exercise	Baseline and after exercise	Executive function was assessed using a Stroop color-word test that participants took using a computer with automated software (Automated Neuropsychological Assessment Metrics, known as ANAM). Score reported are number of correct answers. A higher score means a better outcome, in this case, better executive functioning. Participants took the Stoop color-word test after one week of 8 and 11 hours in bed (i.e., baseline) then the morning after one day of aerobic exercise. Exercise consisted of three sessions of 10 minutes brisk walking at a heart rate considered to be moderate intensity (50-70% of age-predicted maximal heart rate). Results reported reflect the change in score after exercise (morning after exercise minus baseline).
Secondary	Change in Mental Flexibility After Aerobic Exercise	Baseline and after exercise	Mental flexibility was assessed using a Switching task that participants took on a computer with automated software (Automated Neuropsychological Assessment Metrics, known as ANAM). Scores reflect "throughput scores" which is a continuous variable that is the ratio of correct answers per minute during the Manikin test. Higher throughput scores mean better outcome, in this case, better mental flexibility. Participants took the Switching task after one week of 8 and 11 hours in bed (i.e., baseline) then the morning after one day of aerobic exercise. Exercise consisted of three sessions of 10 minutes brisk walking at a heart rate considered to be moderate intensity (50-70% of age-predicted maximal heart rate). Results reported reflect the change in throughput scores after exercise (morning after exercise minus baseline).

Source ClinicalTrials.gov

Outcomes7

Each outcome the trial posted results for, in ClinicalTrials.gov's words.

Type	Outcome	Time frame	Population	Units	Measured as
PRIMARY	Change From Wake in Central Aortic Pulse Pressure After 11 Hours in Bed	One night during each time in bed condition	All participants who completed all study visits were included in the analysis.	mm Hg	MEAN
PRIMARY	Change in Cerebral Vascular Reactivity After 11 Hours in Bed	Morning after one week of 8 and 11 hours in bed	The middle cerebral artery could not be located in 3 participants, so data was analyzed in 9 participants that had complete data.	percent change/Torr	MEAN
PRIMARY	Change in Peak Reactive Hyperemia After 11 Hours in Bed	Morning after one week of 8 and 11 hours in bed	All participants who completed all study visits were included in the analysis.	ml/100ml/min	MEAN
PRIMARY	Change in Arterial Stiffness After 11 Hours in Bed	Morning after one week of 8 and 11 hours in bed	All participants who completed all study visits were included in the analysis.	m/s	MEAN
SECONDARY	Change in Spatial Orientation After Aerobic Exercise	Baseline and after exercise	All participants who completed all study visits were included in the analysis.	correct answers per minute	MEAN
SECONDARY	Change in Executive Function After Aerobic Exercise	Baseline and after exercise	All participants who completed all study visits were included in the analysis.	correct answers	MEAN
SECONDARY	Change in Mental Flexibility After Aerobic Exercise	Baseline and after exercise	All participants who completed all study visits were included in the analysis.	correct answers per minute	MEAN

Source ClinicalTrials.gov

Results by group14

Each measurement the trial posted, group by group, in the words and numbers it posted.

Outcome	Group	Value	Spread	Units
Change From Wake in Central Aortic Pulse Pressure After 11 Hours in Bed	8 Hours in Bed	-1.5	Standard Deviation 8.9	mm Hg
Change From Wake in Central Aortic Pulse Pressure After 11 Hours in Bed	11hours in Bed	0.5	Standard Deviation 5.2	mm Hg
Change in Cerebral Vascular Reactivity After 11 Hours in Bed	8 Hours in Bed	11.9	Standard Deviation 2.8	percent change/Torr
Change in Cerebral Vascular Reactivity After 11 Hours in Bed	11 Hours in Bed	11.3	Standard Deviation 1.8	percent change/Torr
Change in Peak Reactive Hyperemia After 11 Hours in Bed	8 Hours in Bed	20.8	Standard Deviation 5.8	ml/100ml/min
Change in Peak Reactive Hyperemia After 11 Hours in Bed	11 Hours in Bed	24.2	Standard Deviation 7.2	ml/100ml/min
Change in Arterial Stiffness After 11 Hours in Bed	8 Hours in Bed	6.84	Standard Deviation 0.64	m/s
Change in Arterial Stiffness After 11 Hours in Bed	11 Hours in Bed	6.96	Standard Deviation 0.64	m/s
Change in Spatial Orientation After Aerobic Exercise	8 Hours in Bed	7.0	Standard Deviation 4.7	correct answers per minute
Change in Spatial Orientation After Aerobic Exercise	11 Hours in Bed	3.9	Standard Deviation 5.6	correct answers per minute

1 to 10 of 14Source ClinicalTrials.gov

See all 14 results by group

Participant flow6

How many started, completed or left each group, period by period.

Period	Milestone	Group	Participants
Overall Study	STARTED	8, Then 11 Hours in Bed	12
Overall Study	STARTED	11, Then 8 Hours in Bed	11
Overall Study	COMPLETED	8, Then 11 Hours in Bed	6
Overall Study	COMPLETED	11, Then 8 Hours in Bed	6
Overall Study	NOT COMPLETED	8, Then 11 Hours in Bed	6
Overall Study	NOT COMPLETED	11, Then 8 Hours in Bed	5

Source ClinicalTrials.gov

Adverse events0

Each adverse event the trial posted, group by group: the participants affected out of those at risk.

None in this release.

Adverse event totals6

The totals the trial posted for each group.

Total	Group	At risk
Total, all-cause mortality	8 Hours in Bed	12
Total, all-cause mortality	11 Hours in Bed	12
Total, other adverse events	8 Hours in Bed	12
Total, other adverse events	11 Hours in Bed	12
Total, serious adverse events	8 Hours in Bed	12
Total, serious adverse events	11 Hours in Bed	12

Source ClinicalTrials.gov

Papers0

The papers the trial lists on ClinicalTrials.gov.

None in this release.

Grants0

The grants NIH RePORTER links to the trial, newest funded first: NIH's, and some of AHRQ's, CDC's, FDA's and VA's. Each shows its title, principal investigators, organization and funder in its newest year.

None in this release.

Trial comparisons2

Comparisons of the trial's two groups, calculated by ConductScience from the counts it posted.

Comparison	Source
8 Hours in Bed vs 11 Hours in Bed: deaths from any cause	Trial comparisons
8 Hours in Bed vs 11 Hours in Bed: serious adverse events	Trial comparisons

Tests1

The ConductCognition tests this trial's registered outcomes name, as ScienceGraph matched them in trial-tests-2026-11-12-0.2.1.

Test	Named as
Stroop Color-Word Test	Secondary outcome

Source ConductCognition

Data dates

The day each source was copied for this release.

ClinicalTrials.gov: 2026-11-12; ClinicalTrials.gov
Results, from AACT: 2026-03-23; AACT
NIH grant links: 2026-11-13; NIH RePORTER

Sources 3

ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
ClinicalTrials.govNo license stated
NIH RePORTER's clinical studies and project filesPublic domain

Each source's terms

ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
ClinicalTrials.govnone stated
NIH RePORTER's clinical studies and project filesPublic domain (NIH RePORTER)

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

For software

Read this trial from software.

The record and each of its lists are JSON, twenty rows a page. No key.

GET https://conductscience.org/api/trials/v1/NCT04679051

GET https://conductscience.org/api/trials/v1/NCT04679051/registered

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