Trial · NCT04734379
Rho Kinase (ROCK) Inhibitor in Tauopathies - 1
NCT04734379, Phase 2, Unknown, Woolsey Pharmaceuticals
3 sourcestrials-2026-11-12-0.5.0
Cite this record
ConductScience Library. Rho Kinase (ROCK) Inhibitor in Tauopathies - 1. Trials, record NCT04734379. Release trials-2026-11-12-0.5.0, 12 Nov 2026. https://conductscience.org/library/trials/NCT04734379
On this page
Trial
As registered on ClinicalTrials.gov, in the graph's capture of the registry.
- Title
- Rho Kinase (ROCK) Inhibitor in Tauopathies - 1
- NCT number
- NCT04734379
- Status
- Unknown
- Phases
- Phase 2
- Enrollment
- 15 participants, estimated
- Lead sponsor
- Woolsey Pharmaceuticals
- Conditions
- Progressive Supranuclear Palsy, Corticobasal Syndrome
- Interventions
- Fasudil
- First posted
- 2021-02-02
- Last updated
- 2022-06-03
Source ClinicalTrials.gov
Registered outcomes4
Each outcome the trial registered, primary first, in ClinicalTrials.gov's words.
| List | Outcome | Time frame | Description |
|---|---|---|---|
| Primary | Adverse events | 48 weeks | Incidence of adverse events \[AEs\] and serious adverse events \[SAEs\] as assessed by clinically significant abnormal physical examination findings; changes in vital signs; 12-lead electrocardiogram \[ECG\]; magnetic resonance imaging \[MRI\]; and hematology, blood chemistry, liver function, and urine tests. |
| Secondary | Phosphorylated tau | 48 weeks | Number of participants with changes in concentrations of cerebrospinal fluid (CSF) and plasma phosphorylated tau |
| Secondary | Biomarkers of neurodegeneration | 48 weeks | Number of participants with changes in biomarkers of neurodegeneration, including neurofilament light chain (NfL), and total tau fragment levels. |
| Secondary | Imaging biomarkers of neurodegeneration | 48 weeks | Number of participants with changes in imaging biomarkers of neurodegeneration, including changes in brain volume (whole brain, ventricles, hippocampus, frontal operculum, pre-central gyri, midbrain, pons and superior cerebellar peduncle) and white matter tract integrity (aslant tract, superior longitudinal fasciculus, and superior cerebellar peduncle) as determined by T1-weighted volumetric magnetic resonance imaging (MRI), diffusion tensor imaging (DTI) |
Source ClinicalTrials.gov
Outcomes0
Each outcome the trial posted results for, in ClinicalTrials.gov's words.
None in this release.
Results by group0
Each measurement the trial posted, group by group, in the words and numbers it posted.
None in this release.
Participant flow0
How many started, completed or left each group, period by period.
None in this release.
Adverse events0
Each adverse event the trial posted, group by group: the participants affected out of those at risk.
None in this release.
Adverse event totals0
The totals the trial posted for each group.
None in this release.
Papers0
The papers the trial lists on ClinicalTrials.gov.
None in this release.
Grants0
The grants NIH RePORTER links to the trial, newest funded first: NIH's, and some of AHRQ's, CDC's, FDA's and VA's. Each shows its title, principal investigators, organization and funder in its newest year.
None in this release.
Trial comparisons0
Comparisons of the trial's two groups, calculated by ConductScience from the counts it posted.
None in this release.
Tests0
The ConductCognition tests this trial's registered outcomes name, as ScienceGraph matched them in trial-tests-2026-11-12-0.2.1.
None in this release.
Data dates
The day each source was copied for this release.
Sources 3
- ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
- ClinicalTrials.govNo license stated
- NIH RePORTER's clinical studies and project filesPublic domain
Each source's terms
- ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
- ClinicalTrials.govnone stated
- NIH RePORTER's clinical studies and project filesPublic domain (NIH RePORTER)
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.
For software
Read this trial from software.
The record and each of its lists are JSON, twenty rows a page. No key.
GET https://conductscience.org/api/trials/v1/NCT04734379
GET https://conductscience.org/api/trials/v1/NCT04734379/registered