Trial · NCT04782856

Energy Metabolism in Thyroidectomized Patients

NCT04782856, Phase 2, Completed, Virginia Commonwealth University; results first posted 2024-06-14

3 sourcestrials-2026-11-12-0.5.0

Cite this record

ConductScience Library. Energy Metabolism in Thyroidectomized Patients. Trials, record NCT04782856. Release trials-2026-11-12-0.5.0, 12 Nov 2026. https://conductscience.org/library/trials/NCT04782856

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Trial

As registered on ClinicalTrials.gov, in the graph's capture of the registry.

Title: Energy Metabolism in Thyroidectomized Patients
NCT number: NCT04782856
Status: Completed
Phases: Phase 2
Enrollment: 13 participants, actual
Lead sponsor: Virginia Commonwealth University
Conditions: Thyroid Goiter, Hypothyroidism, Thyroid Cancer
Interventions: Levothyroxine, Liothyronine, Placebo
First posted: 2021-03-04
Last updated: 2024-06-14
Results first posted: 2024-06-14

Source ClinicalTrials.gov

Registered outcomes4

Each outcome the trial registered, primary first, in ClinicalTrials.gov's words.

List	Outcome	Time frame	Description
Primary	Short Term Change in Weight	Baseline to 6 months post surgery	Weight will be measured in kilograms using a stadiometer
Primary	Energy Expenditure (EE)	Baseline to 6 months	24-hour EE will be measured using the whole room indirect calorimeter (WRIC) technique
Primary	Change in Cholesterol	Baseline to 6 months post surgery	Cholesterol will be measured using a standard lipid panel.
Other	Change in Quality of Life	Baseline to 6 months post surgery	ThyPRO-39, a thyroid specific quality of life instrument, was used to assess a participant's quality of life. ThyPRO-39 interrogates 12 individual domains and a composite on the 0 to 100 scale (0 best). A difference of 5 points corresponds to a small to moderate effect between two treatment arms. This outcome represents the change in score between when taken at baseline and then again at 6 months post surgery. The larger the increase in score, the better the improvement in the participant's quality of life. Each domain and the composite are being reported separately.

Source ClinicalTrials.gov

Outcomes4

Each outcome the trial posted results for, in ClinicalTrials.gov's words.

Type	Outcome	Time frame	Units	Measured as
PRIMARY	Short Term Change in Weight	Baseline to 6 months post surgery	Kilogram	MEAN
PRIMARY	Energy Expenditure (EE)	Baseline to 6 months	calorie over 24 hours	MEAN
PRIMARY	Change in Cholesterol	Baseline to 6 months post surgery	mg/dL	MEAN
OTHER_PRE_SPECIFIED	Change in Quality of Life	Baseline to 6 months post surgery	score on a scale	MEAN

Source ClinicalTrials.gov

Results by group32

Each measurement the trial posted, group by group, in the words and numbers it posted.

Outcome	Group	Category	Value	Spread	Units
Short Term Change in Weight	Single Therapy		1.7	Standard Deviation 3.9	Kilogram
Short Term Change in Weight	Combination Therapy		-0.76	Standard Deviation 2.1	Kilogram
Energy Expenditure (EE)	Single Therapy		-39	Standard Deviation 68	calorie over 24 hours
Energy Expenditure (EE)	Combination Therapy		25	Standard Deviation 29	calorie over 24 hours
Change in Cholesterol	Single Therapy		43	Standard Deviation 73	mg/dL
Change in Cholesterol	Combination Therapy		-35	Standard Deviation 52	mg/dL
Change in Quality of Life	Single Therapy	Composite	14.3	Standard Deviation 28.3	score on a scale
Change in Quality of Life	Combination Therapy	Composite	45	Standard Deviation 64.7	score on a scale
Change in Quality of Life	Single Therapy	Domain: Goiter	23.8	Standard Deviation 36.8	score on a scale
Change in Quality of Life	Combination Therapy	Domain: Goiter	45	Standard Deviation 38	score on a scale

1 to 10 of 32Source ClinicalTrials.gov

See all 32 results by group

Participant flow6

How many started, completed or left each group, period by period.

Period	Milestone	Group	Participants
Overall Study	STARTED	Single Therapy	7
Overall Study	STARTED	Combination Therapy	6
Overall Study	COMPLETED	Single Therapy	7
Overall Study	COMPLETED	Combination Therapy	5
Overall Study	NOT COMPLETED	Single Therapy	0
Overall Study	NOT COMPLETED	Combination Therapy	1

Source ClinicalTrials.gov

Adverse events2

Each adverse event the trial posted, group by group: the participants affected out of those at risk.

Type	Event	Organ system	Group	Affected	At risk	Events
other	Unexpected TSH Suppression	Endocrine disorders	Single Therapy	0	7	0
other	Unexpected TSH Suppression	Endocrine disorders	Combination Therapy	1	6	1

Source ClinicalTrials.gov

Adverse event totals6

The totals the trial posted for each group.

Total	Group	Affected	At risk
Total, all-cause mortality	Single Therapy	0	7
Total, all-cause mortality	Combination Therapy	0	6
Total, other adverse events	Single Therapy	0	7
Total, other adverse events	Combination Therapy	1	6
Total, serious adverse events	Single Therapy	0	7
Total, serious adverse events	Combination Therapy	0	6

Source ClinicalTrials.gov

Papers0

The papers the trial lists on ClinicalTrials.gov.

None in this release.

Grants1

The grants NIH RePORTER links to the trial, newest funded first: NIH's, and some of AHRQ's, CDC's, FDA's and VA's. Each shows its title, principal investigators, organization and funder in its newest year.

Project	Title	Principal investigators	Organization	Funder	Fiscal years
R21DK122310	Energy Metabolism in Thyroidectomized Patients	STAMATOULI, ANGELIKI MARIA	VIRGINIA COMMONWEALTH UNIVERSITY	NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES	2020 to 2021

Source NIH RePORTER

Trial comparisons2

Comparisons of the trial's two groups, calculated by ConductScience from the counts it posted.

Comparison	Source
Single Therapy vs Combination Therapy: deaths from any cause	Trial comparisons
Single Therapy vs Combination Therapy: serious adverse events	Trial comparisons

Tests0

The ConductCognition tests this trial's registered outcomes name, as ScienceGraph matched them in trial-tests-2026-11-12-0.2.1.

None in this release.

Data dates

The day each source was copied for this release.

ClinicalTrials.gov: 2026-11-12; ClinicalTrials.gov
Results, from AACT: 2026-03-23; AACT
NIH grant links: 2026-11-13; NIH RePORTER

Sources 3

ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
ClinicalTrials.govNo license stated
NIH RePORTER's clinical studies and project filesPublic domain

Each source's terms

ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
ClinicalTrials.govnone stated
NIH RePORTER's clinical studies and project filesPublic domain (NIH RePORTER)

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

For software

Read this trial from software.

The record and each of its lists are JSON, twenty rows a page. No key.

GET https://conductscience.org/api/trials/v1/NCT04782856

GET https://conductscience.org/api/trials/v1/NCT04782856/results?page=2

API reference For AI assistants