Trial · NCT04797286
Sildenafil for Early Pulmonary Vascular Disease in Scleroderma
NCT04797286, Phase 2, Recruiting, Johns Hopkins University
3 sourcestrials-2026-11-12-0.5.0
Cite this record
ConductScience Library. Sildenafil for Early Pulmonary Vascular Disease in Scleroderma. Trials, record NCT04797286. Release trials-2026-11-12-0.5.0, 12 Nov 2026. https://conductscience.org/library/trials/NCT04797286
On this page
Trial
As registered on ClinicalTrials.gov, in the graph's capture of the registry.
- Title
- Sildenafil for Early Pulmonary Vascular Disease in Scleroderma
- NCT number
- NCT04797286
- Status
- Recruiting
- Phases
- Phase 2
- Enrollment
- 30 participants, estimated
- Lead sponsor
- Johns Hopkins University
- Conditions
- Scleroderma, Mildly Elevated Pulmonary Pressures
- Interventions
- Sildenafil, Placebo
- First posted
- 2021-03-15
- Last updated
- 2026-09-28
Source ClinicalTrials.gov
Registered outcomes13
Each outcome the trial registered, primary first, in ClinicalTrials.gov's words.
| List | Outcome | Time frame | Description |
|---|---|---|---|
| Primary | Difference in change in distance walked in 6 minute walk test (6MWT) at 4 months | Baseline and 4 months | As assessed by change in 6 minute walk distance (6MWD) in feet (from baseline to 4 months) between the sildenafil group and the placebo group. |
| Secondary | Difference in change in distance walked in 6MWT at 12 months | Baseline and 12 months | As assessed by change in 6 minute walk test distance in feet (from baseline to 12 months) between the sildenafil group and the placebo group. |
| Secondary | Difference in change in right ventricular function as assessed by cardiac MRI | Baseline and 4 months | As assessed by change in right ventricular function (normal/abnormal) on cardiac MRI. |
| Secondary | Difference in change in right ventricular function as assessed by cardiac MRI | Baseline and 12 months | As assessed by change in right ventricular function (normal/abnormal) on cardiac MRI. |
| Secondary | Difference in change in right ventricular function as assessed by invasive hemodynamics | Baseline and 4 months | As assessed by change in right ventricular function (normal/abnormal) on invasive hemodynamics. |
| Secondary | Difference in change in right ventricular function as assessed by invasive hemodynamics | Baseline and 12 months | As assessed by change in right ventricular function (normal/abnormal) on invasive hemodynamics. |
| Secondary | Difference in change in right ventricular function as assessed by echocardiography | Baseline and 4 months | As assessed by change in right ventricular function (normal/abnormal) on echocardiography. |
| Secondary | Difference in change in right ventricular function as assessed by echocardiography | Baseline and 12 months | As assessed by change in right ventricular function (normal/abnormal) on echocardiography. |
| Secondary | Difference in change in N-terminal pro b-type natriuretic peptide level | Baseline, 4 months and 12 months | As assessed by changes in plasma N-terminal pro b-type natriuretic peptide (NT-proBNP) level (pg/mL) between sildenafil and placebo groups at four months and twelve months. |
| Secondary | Difference in change in health related quality of life as assessed by the 36-Item Short Form Health Survey (SF36) questionnaire | Baseline, 4 months and 12 months | As assessed by changes in SF36 questionnaire between sildenafil and placebo groups at four months and twelve months. The SF36 yields a set of scaled scores in 8 domains, with higher numbers representing a better quality of life. Each scale is scored on a 0 to 100 range so that the lowest and highest possible scores are 0 and 100, respectively. Scores represent the percentage of total possible score achieved. In step 2, items in the same scale are averaged together to create the 8 scale scores. Items that are left blank (missing data) are not taken into account when calculating the scale scores. Hence, scale scores represent the average for all items in the scale that the respondent answered. |
1 to 10 of 13Source ClinicalTrials.gov
See all 13 registered outcomesOutcomes0
Each outcome the trial posted results for, in ClinicalTrials.gov's words.
None in this release.
Results by group0
Each measurement the trial posted, group by group, in the words and numbers it posted.
None in this release.
Participant flow0
How many started, completed or left each group, period by period.
None in this release.
Adverse events0
Each adverse event the trial posted, group by group: the participants affected out of those at risk.
None in this release.
Adverse event totals0
The totals the trial posted for each group.
None in this release.
Papers1
The papers the trial lists on ClinicalTrials.gov.
| PMID | Listed as |
|---|---|
| 38689245 | DERIVED |
Source PubMed
Grants0
The grants NIH RePORTER links to the trial, newest funded first: NIH's, and some of AHRQ's, CDC's, FDA's and VA's. Each shows its title, principal investigators, organization and funder in its newest year.
None in this release.
Trial comparisons0
Comparisons of the trial's two groups, calculated by ConductScience from the counts it posted.
None in this release.
Tests0
The ConductCognition tests this trial's registered outcomes name, as ScienceGraph matched them in trial-tests-2026-11-12-0.2.1.
None in this release.
Data dates
The day each source was copied for this release.
Sources 3
- ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
- ClinicalTrials.govNo license stated
- NIH RePORTER's clinical studies and project filesPublic domain
Each source's terms
- ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
- ClinicalTrials.govnone stated
- NIH RePORTER's clinical studies and project filesPublic domain (NIH RePORTER)
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.
For software
Read this trial from software.
The record and each of its lists are JSON, twenty rows a page. No key.
GET https://conductscience.org/api/trials/v1/NCT04797286
GET https://conductscience.org/api/trials/v1/NCT04797286/registered