Trial · NCT04833777

Does a Different Local Anesthetic Improve Pain After Carpal Tunnel Release?

NCT04833777, Not applicable, Completed, University of Saskatchewan; results first posted 2025-02-10

3 sourcestrials-2026-11-12-0.5.0

Cite this record

ConductScience Library. Does a Different Local Anesthetic Improve Pain After Carpal Tunnel Release? Trials, record NCT04833777. Release trials-2026-11-12-0.5.0, 12 Nov 2026. https://conductscience.org/library/trials/NCT04833777

On this page

Trial

As registered on ClinicalTrials.gov, in the graph's capture of the registry.

Title: Does a Different Local Anesthetic Improve Pain After Carpal Tunnel Release?
NCT number: NCT04833777
Status: Completed
Phases: Not applicable
Enrollment: 140 participants, actual
Lead sponsor: University of Saskatchewan
Conditions: Carpal Tunnel Syndrome
Interventions: Local Anesthetics Lidocaine, Local Anesthetics Bupivacaine
First posted: 2021-04-06
Last updated: 2025-02-10
Results first posted: 2025-02-10

Source ClinicalTrials.gov

Registered outcomes17

Each outcome the trial registered, primary first, in ClinicalTrials.gov's words.

List	Outcome	Time frame	Description
Primary	Post-operative Pain	2 hours post-op	Severity of pain as measured by the Visual Analogue Scale. This tool asks patients to rate their post-operative pain level from 0 to 10. 0 represents no pain, while 10 represents the worst possible pain.
Primary	Post-operative Pain	4 hours post-op	Severity of pain as measured by the Visual Analogue Scale. This tool asks patients to rate their post-operative pain level from 0 to 10. 0 represents no pain, while 10 represents the worst possible pain.
Primary	Post-operative Pain	6 hours post-op	Severity of pain as measured by the Visual Analogue Scale. This tool asks patients to rate their post-operative pain level from 0 to 10. 0 represents no pain, while 10 represents the worst possible pain.
Primary	Post-operative Pain	8 hours post-op	Severity of pain as measured by the Visual Analogue Scale. This tool asks patients to rate their post-operative pain level from 0 to 10. 0 represents no pain, while 10 represents the worst possible pain.
Primary	Post-operative Pain	10 hours post-op	Severity of pain as measured by the Visual Analogue Scale. This tool asks patients to rate their post-operative pain level from 0 to 10. 0 represents no pain, while 10 represents the worst possible pain.
Primary	Post-operative Pain	24 hours post-op	Severity of pain as measured by the Visual Analogue Scale. This tool asks patients to rate their post-operative pain level from 0 to 10. 0 represents no pain, while 10 represents the worst possible pain.
Primary	Post-operative Analgesia Requirements	24 hours	Number of Tylenol and Ibuprofen tablets taken post-operatively within the first 24 hours. This was not measured on a scale. Patients were asked to count the total number of Tylenol (500mg) and Ibuprofen (200mg) tablets they consumed within the first 24 hours after surgery.
Primary	Post-operative Analgesia Requirements	72 hours	Number of Tylenol and Ibuprofen tablets taken post-operatively within the first 24 hours. This was not measured on a scale. Patients were asked to count the total number of Tylenol (500mg) and Ibuprofen (200mg) tablets they consumed within the first 72 hours after surgery.
Secondary	Post-operative Numbness	2 hours post-op	Presence of post-operative numbness in any finger (thumb, index, middle, ring, or little finger). Patients answer "yes" or "no" to numbness.
Secondary	Post-operative Numbness	4 hours post-op	Presence of post-operative numbness in any finger (thumb, index, middle, ring, or little finger). Patients answer "yes" or "no" to numbness.

1 to 10 of 17Source ClinicalTrials.gov

See all 17 registered outcomes

Outcomes17

Each outcome the trial posted results for, in ClinicalTrials.gov's words.

Type	Outcome	Time frame	Units	Measured as
PRIMARY	Post-operative Pain	2 hours post-op	score on a scale	MEAN
PRIMARY	Post-operative Pain	4 hours post-op	score on a scale	MEAN
PRIMARY	Post-operative Pain	6 hours post-op	score on a scale	MEAN
PRIMARY	Post-operative Pain	8 hours post-op	score on a scale	MEAN
PRIMARY	Post-operative Pain	10 hours post-op	score on a scale	MEAN
PRIMARY	Post-operative Pain	24 hours post-op	score on a scale	MEAN
PRIMARY	Post-operative Analgesia Requirements	24 hours	number of tablets	MEAN
PRIMARY	Post-operative Analgesia Requirements	72 hours	number of tablets	MEAN
SECONDARY	Post-operative Numbness	2 hours post-op	wrists	COUNT_OF_UNITS
SECONDARY	Post-operative Numbness	4 hours post-op	wrists	COUNT_OF_UNITS

1 to 10 of 17Source ClinicalTrials.gov

See all 17 outcomes

Results by group40

Each measurement the trial posted, group by group, in the words and numbers it posted.

Outcome	Group	Value	Spread	Units
Post-operative Pain	Lidocaine	1.16	Standard Deviation 1.83	score on a scale
Post-operative Pain	Bupivacaine	0.92	Standard Deviation 1.61	score on a scale
Post-operative Pain	Lidocaine	2.16	Standard Deviation 2.23	score on a scale
Post-operative Pain	Bupivacaine	1.54	Standard Deviation 1.98	score on a scale
Post-operative Pain	Lidocaine	3.19	Standard Deviation 2.29	score on a scale
Post-operative Pain	Bupivacaine	2.29	Standard Deviation 2.35	score on a scale
Post-operative Pain	Lidocaine	3.87	Standard Deviation 2.24	score on a scale
Post-operative Pain	Bupivacaine	2.92	Standard Deviation 2.30	score on a scale
Post-operative Pain	Lidocaine	3.81	Standard Deviation 2.32	score on a scale
Post-operative Pain	Bupivacaine	3.38	Standard Deviation 2.42	score on a scale

1 to 10 of 40Source ClinicalTrials.gov

See all 40 results by group

Participant flow8

How many started, completed or left each group, period by period.

Period	Milestone	Group	Participants	Units counted
Overall Study	STARTED	Lidocaine	68	68
Overall Study	STARTED	Bupivacaine	72	72
Overall Study	Data Analysis	Lidocaine	67	67
Overall Study	Data Analysis	Bupivacaine	72	72
Overall Study	COMPLETED	Lidocaine	67	67
Overall Study	COMPLETED	Bupivacaine	72	72
Overall Study	NOT COMPLETED	Lidocaine	1	1
Overall Study	NOT COMPLETED	Bupivacaine	0	0

Source ClinicalTrials.gov

Adverse events0

Each adverse event the trial posted, group by group: the participants affected out of those at risk.

None in this release.

Adverse event totals6

The totals the trial posted for each group.

Total	Group	At risk
Total, all-cause mortality	Lidocaine	67
Total, all-cause mortality	Bupivacaine	72
Total, other adverse events	Lidocaine	67
Total, other adverse events	Bupivacaine	72
Total, serious adverse events	Lidocaine	67
Total, serious adverse events	Bupivacaine	72

Source ClinicalTrials.gov

Papers0

The papers the trial lists on ClinicalTrials.gov.

None in this release.

Grants0

The grants NIH RePORTER links to the trial, newest funded first: NIH's, and some of AHRQ's, CDC's, FDA's and VA's. Each shows its title, principal investigators, organization and funder in its newest year.

None in this release.

Trial comparisons2

Comparisons of the trial's two groups, calculated by ConductScience from the counts it posted.

Comparison	Source
Lidocaine vs Bupivacaine: deaths from any cause	Trial comparisons
Lidocaine vs Bupivacaine: serious adverse events	Trial comparisons

Tests0

The ConductCognition tests this trial's registered outcomes name, as ScienceGraph matched them in trial-tests-2026-11-12-0.2.1.

None in this release.

Data dates

The day each source was copied for this release.

ClinicalTrials.gov: 2026-11-12; ClinicalTrials.gov
Results, from AACT: 2026-03-23; AACT
NIH grant links: 2026-11-13; NIH RePORTER

Sources 3

ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
ClinicalTrials.govNo license stated
NIH RePORTER's clinical studies and project filesPublic domain

Each source's terms

ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
ClinicalTrials.govnone stated
NIH RePORTER's clinical studies and project filesPublic domain (NIH RePORTER)

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

For software

Read this trial from software.

The record and each of its lists are JSON, twenty rows a page. No key.

GET https://conductscience.org/api/trials/v1/NCT04833777

GET https://conductscience.org/api/trials/v1/NCT04833777/results?page=2

API reference For AI assistants