Trial · NCT04836533
Enhancing Processing Speed and Executive Functioning in Depressed Older Adults With Computerized Cognitive Training
NCT04836533, Phase 1, Withdrawn, Queens College, The City University of New York
3 sourcestrials-2026-11-12-0.5.0
Cite this record
ConductScience Library. Enhancing Processing Speed and Executive Functioning in Depressed Older Adults With Computerized Cognitive Training. Trials, record NCT04836533. Release trials-2026-11-12-0.5.0, 12 Nov 2026. https://conductscience.org/library/trials/NCT04836533
On this page
Trial
As registered on ClinicalTrials.gov, in the graph's capture of the registry.
- Title
- Enhancing Processing Speed and Executive Functioning in Depressed Older Adults With Computerized Cognitive Training
- NCT number
- NCT04836533
- Status
- Withdrawn
- Phases
- Phase 1
- Enrollment
- 0 participants, actual
- Lead sponsor
- Queens College, The City University of New York
- Conditions
- Depression in Old Age, Depression
- Interventions
- Experimental: Computerized Cognitive Training, Experimental: Open-label antidepressant treatment, Active Comparator: Solitaire Training, Placebo Comparator: Placebo-controlled antidepressant treatment
- First posted
- 2021-04-08
- Last updated
- 2023-03-28
Source ClinicalTrials.gov
Registered outcomes25
Each outcome the trial registered, primary first, in ClinicalTrials.gov's words.
| List | Outcome | Time frame | Description |
|---|---|---|---|
| Primary | Hamilton Rating Scale for Depression (HRSD) Change | Screen, Weeks 0, 1, 2, 3, 4, 6, 8, 10, 12 | Clinician-rated measure of depressive severity composed of 24 questions used to measure changes in depressive symptoms and monitor safety during the study. |
| Primary | Treatment Credibility Expectancy Scale (CES) - item 4 Change | Baseline, Week 0 | Self-report scale in which subjects rate their impression of the credibility of the treatment and how they estimate their expectation of improvement. Item 4 measures how much improvement in depression symptoms is expected. |
| Primary | Processing Speed Change - WAIS-IV Coding | Baseline, Weeks 4, 12 | Processing speed will be assessed using Coding from the Wechsler Adult Intelligence Scale-IV (WAIS-IV), the NIH Toolbox Pattern Comparison Processing Speed Test, and Trail Making Test A. From these 3 tests, a composite score (primary outcome) is derived by extracting a latent factor and factor loadings, creating a purer measure of processing speed than raw scores from an individual test or a sum total score. |
| Primary | Processing Speed Change - NIHH Toolbox Pattern Comparison Processing Speed Test | Baseline, Weeks 4, 12 | Processing speed will be assessed using Coding from the Wechsler Adult Intelligence Scale-IV (WAIS-IV), the NIH Toolbox Pattern Comparison Processing Speed Test, and Trail Making Test A. From these 3 tests, a composite score (primary outcome) is derived by extracting a latent factor and factor loadings, creating a purer measure of processing speed than raw scores from an individual test or a sum total score. |
| Primary | Processing Speed Change - Trail Making Test A | Baseline, Weeks 4, 12 | Processing speed will be assessed using Coding from the Wechsler Adult Intelligence Scale-IV (WAIS-IV), the NIH Toolbox Pattern Comparison Processing Speed Test, and Trail Making Test A. From these 3 tests, a composite score (primary outcome) is derived by extracting a latent factor and factor loadings, creating a purer measure of processing speed than raw scores from an individual test or a sum total score. |
| Primary | Resting State Functional Connectivity Index Change | Baseline, Week 4 | Measure of resting state fMRI. |
| Secondary | Secondary Clinical Global Impressions (CGI) Severity and Improvement | Screen, Weeks 0, 1, 2, 3, 4, 6, 8, 10, 12 | Scales measuring the clinician's view of subjects' global functioning that will provide a clinical assessment of subjects at each visit and help maintain safety by identifying clinical worsening. |
| Secondary | Inventory for Depressive Symptomatology Self-Report (IDS-SR) | Weeks 0, 1, 2, 3, 4, 6, 8, 10, 12 | The IDS-SR is a standard self-report measure of depression severity that will be used to measure changes in depressive symptoms and monitor safety during the study. |
| Secondary | Cumulative Illness Rating Scale for Geriatrics (CIRS-G) | Screen | Provides quantitative ratings of chronic illness burden. Presence of illness is rated from 0 to 4 in 14 different medical domains. Scores range from 0-56. |
| Secondary | NIH Toolbox Auditory Verbal Learning Test - Rey (RAVLT) | Baseline, Weeks 4, 12 | Measures immediate recall. Unrelated words presented via audio recording and participant recalls as many as possible |
1 to 10 of 25Source ClinicalTrials.gov
See all 25 registered outcomesOutcomes0
Each outcome the trial posted results for, in ClinicalTrials.gov's words.
None in this release.
Results by group0
Each measurement the trial posted, group by group, in the words and numbers it posted.
None in this release.
Participant flow0
How many started, completed or left each group, period by period.
None in this release.
Adverse events0
Each adverse event the trial posted, group by group: the participants affected out of those at risk.
None in this release.
Adverse event totals0
The totals the trial posted for each group.
None in this release.
Papers0
The papers the trial lists on ClinicalTrials.gov.
None in this release.
Grants1
The grants NIH RePORTER links to the trial, newest funded first: NIH's, and some of AHRQ's, CDC's, FDA's and VA's. Each shows its title, principal investigators, organization and funder in its newest year.
| Project | Title | Principal investigators | Organization | Funder | Fiscal years |
|---|---|---|---|---|---|
| R33MH126187 | Optimizing placebo effects in depressed older adults: Enhancing processing speed and executive functioning with computerized cognitive training | SNEED, JOEL R. | QUEENS COLLEGE | NATIONAL INSTITUTE OF MENTAL HEALTH | 2021 |
Source NIH RePORTER
Trial comparisons0
Comparisons of the trial's two groups, calculated by ConductScience from the counts it posted.
None in this release.
Tests11
The ConductCognition tests this trial's registered outcomes name, as ScienceGraph matched them in trial-tests-2026-11-12-0.2.1.
| Test | Named as | Source |
|---|---|---|
| Pattern and Letter Comparison | Primary outcome | ConductCognition |
| Trail Making Test A | Primary outcome | ConductCognition |
| Trail Making Test B | Primary outcome | ConductCognition |
| Category Fluency | Secondary outcome | ConductCognition |
| Picture Order Memory Test | Secondary outcome | ConductCognition |
| Size Order Memory Test | Secondary outcome | ConductCognition |
| Stroop Color-Word Test | Secondary outcome | ConductCognition |
| Symbol Coding | Other outcome | ConductCognition |
| Verbal Fluency | Secondary outcome | ConductCognition |
| Verbal Learning | Secondary outcome | ConductCognition |
1 to 10 of 11
See all 11 testsData dates
The day each source was copied for this release.
Sources 3
- ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
- ClinicalTrials.govNo license stated
- NIH RePORTER's clinical studies and project filesPublic domain
Each source's terms
- ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
- ClinicalTrials.govnone stated
- NIH RePORTER's clinical studies and project filesPublic domain (NIH RePORTER)
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.
For software
Read this trial from software.
The record and each of its lists are JSON, twenty rows a page. No key.
GET https://conductscience.org/api/trials/v1/NCT04836533
GET https://conductscience.org/api/trials/v1/NCT04836533/registered?page=2