Combined Exercise Trial
NCT04848038, Not applicable, Completed, University of Kansas Medical Center
Trial 10
As registered on ClinicalTrials.gov, in the graph's capture of the registry.
| Field | Value | Source |
|---|---|---|
| Title | Combined Exercise Trial | ClinicalTrials.gov |
| NCT number | NCT04848038 | ClinicalTrials.gov |
| Status | Completed | ClinicalTrials.gov |
| Phases | Not applicable | ClinicalTrials.gov |
| Enrollment | 282 participants, actual | ClinicalTrials.gov |
| Lead sponsor | University of Kansas Medical Center | ClinicalTrials.gov |
| Conditions | Healthy Aging | ClinicalTrials.gov |
| Interventions | Exercise | ClinicalTrials.gov |
| First posted | 2021-04-19 | ClinicalTrials.gov |
| Last updated | 2026-06-03 | ClinicalTrials.gov |
Registered outcomes 43
Each outcome the trial registered, primary first, in ClinicalTrials.gov's words.
| List | Outcome | Time frame | Description | Source |
|---|---|---|---|---|
| Primary | Global Cognition | Baseline, 6 months, 12 months | Assessing change in cognitive function from baseline to 12 months. The 6 month measure is being used to assess the trajectory of the change. A comprehensive neuropsychological battery will be used that assesses a global cognition score derived from domains of cognition (e.g. Executive Function, Visuospatial Processing, Episodic Memory, Processing Speed). We will use a second order confirmatory factor analysis (CFA) to estimate the factor loadings between the observed indicators and the first order factors and between the first and second order factors. The CFA will use baseline data to avoid any potential intervention related biases. The primary outcome will be constructed by summing the weighted average (by the estimated first and second order loadings) of the standardized observed scores across the cognitive tests. | ClinicalTrials.gov |
| Secondary | Hippocampal volume | Baseline, 12 months | Volume of bilateral hippocampus in milliliters | ClinicalTrials.gov |
| Secondary | Peak oxygen consumption | Baseline, 12 months | Peak volume of oxygen used in in milliliters per kilogram of body mass per minute during a graded maximal exercise test | ClinicalTrials.gov |
| Secondary | 1-Repetition Maximum | Baseline, 12 months | The maximum amount of mass that can be lifted one time (summed leg press and chest press) | ClinicalTrials.gov |
| Other | Wechsler Test of Adult Reading | Baseline | The Wechsler Test of Adult Reading is a reading recognition test that can be used to estimate intelligence quotient and memory scores | ClinicalTrials.gov |
| Other | Hopkins Verbal Learning Test - Revised | Baseline, 6 months, 12 months | The Hopkins Verbal Learning Test - Revised is an oral test that has been validated within brain-disordered populations (e.g., Alzheimer's disease, amnestic disorders) as a measure of verbal learning and memory. | ClinicalTrials.gov |
| Other | NIH Toolbox Flanker Task | Baseline, 6 months, 12 months | The NIH ToolboxFlanker Task is a computer based test to assess selective attention and inhibitory function. | ClinicalTrials.gov |
| Other | NIH Toolbox Dimensional Change Card Sort | Baseline, 6 months, 12 months | The NIH Toolbox Dimensional Change Card Sort is a computer based test to assess cognitive flexibility and attention. | ClinicalTrials.gov |
| Other | NIH Toolbox Oral Symbol Digit Test | Baseline, 6 months, 12 months | The NIH Toolbox Oral Symbol Digit Test is a computer based test to Measure of processing speed. | ClinicalTrials.gov |
| Other | Virginia Cognitive Aging Project Logical Memory | Baseline, 6 months, 12 months | The Virginia Cognitive Aging Project Logical Memory test measures episodic verbal memory. | ClinicalTrials.gov |
| Other | Spatial Relations | Baseline, 26-weeks, 52-weeks | In this computer task, participants are asked to determine which three-dimensional figure can be formed from a two-dimensional pattern presented. This task measures visual construction ability. | ClinicalTrials.gov |
| Other | Letter Comparison | Baseline, 6 months, 12 months | This paper-based task measures processing speed. | ClinicalTrials.gov |
| Other | Matrix Reasoning | Baseline, 6 months, 12 months | This computer-based task measures visuospatial ability. | ClinicalTrials.gov |
| Other | Task Switching | Baseline, 6 months, 12 months | This computer task asks participants to learn two different tasks. This task measures task switching. | ClinicalTrials.gov |
| Other | Spatial Working Memory | Baseline, 6 months, 12 months | This computer task measures spatial memory. | ClinicalTrials.gov |
| Other | Stroop Task | Baseline, 6 months, 12 months | This paper-based oral task measures executive control, specifically attention and inhibitory control. | ClinicalTrials.gov |
| Other | Fat Mass | Baseline, 12 months | Estimated total body, axial, appendicular and visceral fat mass from dual x-ray absorptiometry. | ClinicalTrials.gov |
| Other | Lean Mass | Baseline, 12 months | Estimated total body, axial, appendicular lean mass from dual x-ray absorptiometry. | ClinicalTrials.gov |
| Other | Bone Mass | Baseline, 12 months | Estimated total body, axial, appendicular bone mass and density from dual x-ray absorptiometry. | ClinicalTrials.gov |
| Other | Cerebral brain blood flow | Baseline, 12 months | Whole brain and regional cerebral blood flow estimated using arterial spin labeling, a technique of magnetic resonance imaging | ClinicalTrials.gov |
Outcomes 0
Each outcome the trial posted results for, in ClinicalTrials.gov's words.
| Type | Outcome | Time frame | Population | Units | Measured as | Source |
|---|
Results by group 0
Each measurement the trial posted, group by group, in the words and numbers it posted.
| Outcome | Group | Category | Value | Spread | Units | Source |
|---|
Participant flow 0
How many started, completed or left each group, period by period.
| Period | Milestone | Group | Participants | Units counted | Source |
|---|
Adverse events 0
Each adverse event the trial posted, group by group: the participants affected out of those at risk.
| Type | Event | Organ system | Group | Affected | At risk | Events | Source |
|---|
Adverse event totals 0
The totals the trial posted for each group.
| Total | Group | Affected | At risk | Source |
|---|
Papers 1
The papers the trial lists on ClinicalTrials.gov.
| PMID | Listed as | Source |
|---|---|---|
| 38011138 | DERIVED | PubMed |
Grants 0
The grants NIH RePORTER links to the trial, newest funded first: NIH's, and some of AHRQ's, CDC's, FDA's and VA's. Each shows its title, principal investigators, organization and funder in its newest year.
| Project | Title | Principal investigators | Organization | Funder | Fiscal years | Source |
|---|
Trial comparisons 0
Comparisons of the trial's two groups, calculated by ConductScience from the counts it posted.
| Comparison | Source |
|---|
Tests 8
The ConductCognition tests this trial's registered outcomes name, as ScienceGraph matched them in trial-tests-2026-11-12-0.2.1.
| Test | Named as | Source |
|---|---|---|
| Dimensional Change Card Sort | Other outcome | ConductCognition |
| Eriksen Flanker Task | Other outcome | ConductCognition |
| Matrix Reasoning | Other outcome | ConductCognition |
| Short Story Recall | Other outcome | ConductCognition |
| Stroop Color-Word Test | Other outcome | ConductCognition |
| Symbol Coding | Other outcome | ConductCognition |
| Task Switching Test | Other outcome | ConductCognition |
| Verbal Learning | Other outcome | ConductCognition |
Source 5
| Field | Value | Source |
|---|---|---|
| Release | trials-2026-11-12-0.4.0 | ClinicalTrials.gov |
| Release manifest SHA-256 | 0f4a8d8c48aee2a7573ae0fa94ecbeab70c1adbe449bbc95c424bc7d3e97b9d4 | ClinicalTrials.gov |
| Registry capture | 2026-11-12 | ClinicalTrials.gov |
| Results copy, AACT | 2026-03-23 | ClinicalTrials.gov |
| NIH clinical studies file | 2026-11-13 | ClinicalTrials.gov |
Release trials-2026-11-12-0.4.0
ClinicalTrials.gov's posted results, through CTTI's AACT: ClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299 ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.
ClinicalTrials.gov: none stated ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.
NIH RePORTER's clinical studies and project files: Public domain (NIH RePORTER)