Recovery After Critical Covid-19 Infection
NCT04864938, Unknown, University of Helsinki
Trial 8
As registered on ClinicalTrials.gov, in the graph's capture of the registry.
| Field | Value | Source |
|---|---|---|
| Title | Recovery After Critical Covid-19 Infection | ClinicalTrials.gov |
| NCT number | NCT04864938 | ClinicalTrials.gov |
| Status | Unknown | ClinicalTrials.gov |
| Enrollment | 250 participants, estimated | ClinicalTrials.gov |
| Lead sponsor | University of Helsinki | ClinicalTrials.gov |
| Conditions | Covid-19 | ClinicalTrials.gov |
| First posted | 2021-04-29 | ClinicalTrials.gov |
| Last updated | 2021-04-29 | ClinicalTrials.gov |
Registered outcomes 14
Each outcome the trial registered, primary first, in ClinicalTrials.gov's words.
| List | Outcome | Time frame | Description | Source |
|---|---|---|---|---|
| Primary | Cognitive function 6 months after hospital discharge | 6 months after hospital discharge | Global score calculated from three domains: memory, executive functions and attention.Memory: WMS-III Word list delayed recall + WMS-III Logical memory delayed recall + Rey Complex Figure, delayed recall Executive: TMB (time, reversed) + Stroop interference (time, reversed) + FAB score Attention: WAIS-IV Coding + CPT (correct items) + Stroop naming (time, reversed) The global score will be compared with controls and age matched national references | ClinicalTrials.gov |
| Primary | Diffusion capacity 6 months after hospital discharge | 6 months after hospital discharge | Diffusion capacity DLCO results (percentage of predicted) 6 months after ICU treatment for covid-19 | ClinicalTrials.gov |
| Primary | Incidence of post myocarditis findings in MRI of the heart | 6-12 months after hospital discharge | Incidence of findings in cardiac MRI indicating previous myocarditis in each group | ClinicalTrials.gov |
| Primary | Six minute walk test distance | 6 months after hospital discharge | The distance in meters walked by ICU treated patients in 6 minutes in controlled test environment | ClinicalTrials.gov |
| Primary | Restriction in lung function tests | 6 months after hospital discharge | Restriction in lung function parameters vital capacity and forced vital capacity (z-scores) in measured by spirometry | ClinicalTrials.gov |
| Primary | Cerebral microbleeds | 6 months after hospital discharge | Number and anatomical distribution of cerebral microbleeds in MRI imaging of the brain | ClinicalTrials.gov |
| Primary | Plasma matrix metalloproteinases -8, -9 and TIMP-1 6 months after hospital discharge | 6 moths after hospital discharge | Plasma matrix metalloproteinases -8, -9 and TIMP-1 levels in ng/mL 6 months after hospital discharge | ClinicalTrials.gov |
| Primary | Plasma neurofilament level and its correlation with global score in neuropsychological test battery | 6 months after hospital discharge | Plasma neurofilament level and its correlation with global score in neuropsychological test battery | ClinicalTrials.gov |
| Secondary | Correlation ApoE 4 alleles with disease severity | 6 months post-covid | Laboratory analysis of ApoE alleles and comparison of their frequencies among groups | ClinicalTrials.gov |
| Secondary | Correlation of cerebral microbleeds with neuropsychological global score | 6 moths after hospital discharge | Correlation of type and location of cerebral microbleeds with neuropsychological global score | ClinicalTrials.gov |
| Secondary | Association of the incidence of cerebral microbleeds with findings in cardiac MRI | 6-12 months after hospital discharge | Association of the incidence of cerebral microbleeds with findings in cardiac MRI | ClinicalTrials.gov |
| Secondary | Correlation of plasma neurofilament with cerebral microbleeds | 6 months after hospital discharge | Correlation of plasma neurofilament with cerebral microbleeds in brain MR imaging | ClinicalTrials.gov |
| Secondary | Correlation of 6 minute walk test heart rate variables with cardiac function | 6-12 months after hospital discharge | Correlation of heart rate in rest, exercise and 5 minutes after exercise with cardiac output measured in heart MRI | ClinicalTrials.gov |
| Secondary | Correlation of matrix metalloproteinase 9 with diffusion capacity | 6 months after hospital discharge | Correlation of matrix metalloproteinase 9 (ng/mL) with lung diffusion capacity z-score | ClinicalTrials.gov |
Outcomes 0
Each outcome the trial posted results for, in ClinicalTrials.gov's words.
| Type | Outcome | Time frame | Population | Units | Measured as | Source |
|---|
Results by group 0
Each measurement the trial posted, group by group, in the words and numbers it posted.
| Outcome | Group | Category | Value | Spread | Units | Source |
|---|
Participant flow 0
How many started, completed or left each group, period by period.
| Period | Milestone | Group | Participants | Units counted | Source |
|---|
Adverse events 0
Each adverse event the trial posted, group by group: the participants affected out of those at risk.
| Type | Event | Organ system | Group | Affected | At risk | Events | Source |
|---|
Adverse event totals 0
The totals the trial posted for each group.
| Total | Group | Affected | At risk | Source |
|---|
Papers 3
The papers the trial lists on ClinicalTrials.gov.
Trial comparisons 0
Comparisons of the trial's two groups, calculated by ConductScience from the counts it posted.
| Comparison | Source |
|---|
Tests 3
The ConductCognition tests this trial's registered outcomes name, as ScienceGraph matched them in trial-tests-2026-11-12-0.2.1.
| Test | Named as | Source |
|---|---|---|
| Complex Figure Copy and Recall | Primary outcome | ConductCognition |
| Short Story Recall | Primary outcome | ConductCognition |
| Stroop Color-Word Test | Primary outcome | ConductCognition |
Source 4
| Field | Value | Source |
|---|---|---|
| Release | trials-2026-11-12-0.3.0 | ClinicalTrials.gov |
| Release manifest SHA-256 | 4a570df2e7274cee2d4fa2959402fab41880e2cd412e4b590390035fbea69391 | ClinicalTrials.gov |
| Registry capture | 2026-11-12 | ClinicalTrials.gov |
| Results copy, AACT | 2026-03-23 | ClinicalTrials.gov |
Release trials-2026-11-12-0.3.0
ClinicalTrials.gov's posted results, through CTTI's AACT: ClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299 ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.
ClinicalTrials.gov: none stated ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.