Trial · NCT04930328
Retrospective Real World Oxbryta® Data Collection and Analysis Study
NCT04930328, Completed, Pfizer
3 sourcestrials-2026-11-12-0.5.0
Cite this record
ConductScience Library. Retrospective Real World Oxbryta® Data Collection and Analysis Study. Trials, record NCT04930328. Release trials-2026-11-12-0.5.0, 12 Nov 2026. https://conductscience.org/library/trials/NCT04930328
On this page
Trial
As registered on ClinicalTrials.gov, in the graph's capture of the registry.
- Title
- Retrospective Real World Oxbryta® Data Collection and Analysis Study
- NCT number
- NCT04930328
- Status
- Completed
- Enrollment
- 216 participants, actual
- Lead sponsor
- Pfizer
- Conditions
- Sickle Cell Disease
- Interventions
- Oxbryta® (voxelotor) 500-mg Tablets
- First posted
- 2021-06-18
- Last updated
- 2024-03-06
Source ClinicalTrials.gov
Registered outcomes11
Each outcome the trial registered, primary first, in ClinicalTrials.gov's words.
| List | Outcome | Time frame | Description |
|---|---|---|---|
| Primary | Change from pre-Oxbryta treatment period in Hemoglobin (Hb) | 1 year before and 1 year after the first dose of Oxbryta | |
| Primary | Change from pre-Oxbryta treatment period in percent Reticulocytes | 1 year before and 1 year after the first dose of Oxbryta | |
| Primary | Change from pre-Oxbryta treatment period in Absolute Reticulocytes | 1 year before and 1 year after the first dose of Oxbryta | |
| Primary | Change from pre-Oxbryta treatment period in Bilirubin | 1 year before and 1 year after the first dose of Oxbryta | |
| Primary | Incidence of significant SCD-related clinical events | 1 year before and 1 year after the first dose of Oxbryta | Such as vaso-occlusive crisis (VOC), acute chest syndrome (ACS), priapism, cerebral infarcts, transient ischemic attack (TIA), leg ulcers, and measures of cardiac function and pulmonary hypertension (PH) |
| Primary | Change from pre-Oxbryta treatment period in incidence of unplanned clinic visits | 1 year before and 1 year after the first dose of Oxbryta | |
| Primary | Change from pre-Oxbryta treatment period in incidence of emergency department (ED) visits | 1 year before and 1 year after the first dose of Oxbryta | |
| Primary | Change from pre-Oxbryta treatment period in incidence of hospitalizations (including total length of stay and time in intensive care unit [ICU], if applicable) | 1 year before and 1 year after the first dose of Oxbryta | |
| Primary | Change from pre-Oxbryta treatment period in incidence of red blood cell transfusions | 1 year before and 1 year after the first dose of Oxbryta | |
| Primary | Incidence and severity of serious adverse events (SAEs) | 1 year before and 1 year after the first dose of Oxbryta |
1 to 10 of 11Source ClinicalTrials.gov
See all 11 registered outcomesOutcomes0
Each outcome the trial posted results for, in ClinicalTrials.gov's words.
None in this release.
Results by group0
Each measurement the trial posted, group by group, in the words and numbers it posted.
None in this release.
Participant flow0
How many started, completed or left each group, period by period.
None in this release.
Adverse events0
Each adverse event the trial posted, group by group: the participants affected out of those at risk.
None in this release.
Adverse event totals0
The totals the trial posted for each group.
None in this release.
Papers1
The papers the trial lists on ClinicalTrials.gov.
| PMID | Listed as |
|---|---|
| 41701977 | DERIVED |
Source PubMed
Grants0
The grants NIH RePORTER links to the trial, newest funded first: NIH's, and some of AHRQ's, CDC's, FDA's and VA's. Each shows its title, principal investigators, organization and funder in its newest year.
None in this release.
Trial comparisons0
Comparisons of the trial's two groups, calculated by ConductScience from the counts it posted.
None in this release.
Tests0
The ConductCognition tests this trial's registered outcomes name, as ScienceGraph matched them in trial-tests-2026-11-12-0.2.1.
None in this release.
Data dates
The day each source was copied for this release.
Sources 3
- ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
- ClinicalTrials.govNo license stated
- NIH RePORTER's clinical studies and project filesPublic domain
Each source's terms
- ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
- ClinicalTrials.govnone stated
- NIH RePORTER's clinical studies and project filesPublic domain (NIH RePORTER)
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.
For software
Read this trial from software.
The record and each of its lists are JSON, twenty rows a page. No key.
GET https://conductscience.org/api/trials/v1/NCT04930328
GET https://conductscience.org/api/trials/v1/NCT04930328/registered