Trial · NCT04942834
Using Cryoballoon Ablation as Initial Treatment for Persistent Atrial Fibrillation
NCT04942834, Not applicable, Completed, Ruijin Hospital
3 sourcestrials-2026-11-12-0.5.0
Cite this record
ConductScience Library. Using Cryoballoon Ablation as Initial Treatment for Persistent Atrial Fibrillation. Trials, record NCT04942834. Release trials-2026-11-12-0.5.0, 12 Nov 2026. https://conductscience.org/library/trials/NCT04942834
On this page
Trial
As registered on ClinicalTrials.gov, in the graph's capture of the registry.
- Title
- Using Cryoballoon Ablation as Initial Treatment for Persistent Atrial Fibrillation
- NCT number
- NCT04942834
- Status
- Completed
- Phases
- Not applicable
- Enrollment
- 320 participants, actual
- Lead sponsor
- Ruijin Hospital
- Conditions
- Atrial Fibrillation, Persistent, Arrhythmias, Cardiac
- Interventions
- Antiarrhythmic drug including Propafenone, Sotalol, Dronedarone and Amiodarone, cryoballoon ablation
- First posted
- 2021-06-29
- Last updated
- 2026-08-18
Source ClinicalTrials.gov
Registered outcomes6
Each outcome the trial registered, primary first, in ClinicalTrials.gov's words.
| List | Outcome | Time frame | Description |
|---|---|---|---|
| Primary | Treatment success at 12 months | Randomization to 12 months | Treatment success at 12 months after antiarrhythmic drug (AAD) initiation or ablation utilizing cryoballoon catheter measured by freedom from AF recurrence following a 3-month period after the index ablation or AAD initiation（Dynamic ECG requires a minimum of 30 seconds, while a 12-lead ECG requires at least 10 seconds.）. |
| Secondary | Quality of life changes at 12 months measured by AFEQT | one year | The improvement in quality of life between baseline and 12 months after the index ablation procedure or AAD measured by AF Quality of Life Survey (AFEQT) |
| Secondary | Quality of life changes at 12 months measured by SF-12 | one year | The improvement in quality of life between baseline and 12 months after the index ablation procedure or AAD measured by 12-Item Short Form Survey (SF-12) |
| Secondary | Arrhythmia recurrence during blanking period | 3 months | atrial tachycardia recurrence rate during the blanking period |
| Secondary | time to first time cardiovascular hospitalization (month) | one year | time to first time cardiovascular hospitalization after treatment (month) |
| Secondary | Rate of serious procedure-related and serious cryoablation system-related reported adverse events | one year | Rate of serious procedure-related and serious cryoablation system-related reported adverse events through 12 months after the index ablation procedure |
Source ClinicalTrials.gov
Outcomes0
Each outcome the trial posted results for, in ClinicalTrials.gov's words.
None in this release.
Results by group0
Each measurement the trial posted, group by group, in the words and numbers it posted.
None in this release.
Participant flow0
How many started, completed or left each group, period by period.
None in this release.
Adverse events0
Each adverse event the trial posted, group by group: the participants affected out of those at risk.
None in this release.
Adverse event totals0
The totals the trial posted for each group.
None in this release.
Papers1
The papers the trial lists on ClinicalTrials.gov.
| PMID | Listed as |
|---|---|
| 42677894 | DERIVED |
Source PubMed
Grants0
The grants NIH RePORTER links to the trial, newest funded first: NIH's, and some of AHRQ's, CDC's, FDA's and VA's. Each shows its title, principal investigators, organization and funder in its newest year.
None in this release.
Trial comparisons0
Comparisons of the trial's two groups, calculated by ConductScience from the counts it posted.
None in this release.
Tests0
The ConductCognition tests this trial's registered outcomes name, as ScienceGraph matched them in trial-tests-2026-11-12-0.2.1.
None in this release.
Data dates
The day each source was copied for this release.
Sources 3
- ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
- ClinicalTrials.govNo license stated
- NIH RePORTER's clinical studies and project filesPublic domain
Each source's terms
- ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
- ClinicalTrials.govnone stated
- NIH RePORTER's clinical studies and project filesPublic domain (NIH RePORTER)
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.
For software
Read this trial from software.
The record and each of its lists are JSON, twenty rows a page. No key.
GET https://conductscience.org/api/trials/v1/NCT04942834
GET https://conductscience.org/api/trials/v1/NCT04942834/registered