Trial · NCT04972656
Treatment With Ambrisentan in Patients With Borderline Pulmonary Arterial Hypertension
NCT04972656, Not applicable, Unknown, Nanjing First Hospital, Nanjing Medical University
3 sourcestrials-2026-11-12-0.4.0
Cite this record
ConductScience Library. Treatment With Ambrisentan in Patients With Borderline Pulmonary Arterial Hypertension. Trials, record NCT04972656. Release trials-2026-11-12-0.4.0, 12 Nov 2026. https://conductscience.org/library/trials/NCT04972656
On this page
Trial
As registered on ClinicalTrials.gov, in the graph's capture of the registry.
- Title
- Treatment With Ambrisentan in Patients With Borderline Pulmonary Arterial Hypertension
- NCT number
- NCT04972656
- Status
- Unknown
- Phases
- Not applicable
- Enrollment
- 420 participants, estimated
- Lead sponsor
- Nanjing First Hospital, Nanjing Medical University
- Conditions
- Pulmonary Arterial Hypertension
- Interventions
- Ambrisentan, Placebo
- First posted
- 2021-07-22
- Last updated
- 2022-09-28
Source ClinicalTrials.gov
Registered outcomes13
Each outcome the trial registered, primary first, in ClinicalTrials.gov's words.
| List | Outcome | Time frame | Description |
|---|---|---|---|
| Primary | Incidence of diagnostic PAH (mPAP ≥25 mmHg) | baseline, 1 year | Determine whether mean pulmonary arterial pressure of patients with borderline - PAH (mPAP 21-24 mmHg) can be reduced by 3 mm Hg (absolute change baseline vs. 1 year; equals 15%) following treatment with ambrisentan 10 mg/die (initiated with 5 mg/die and elevated up to 10 mg/die) over 1 year (primary endpoint) compared to baseline and placebo. |
| Primary | Change of Pulmonary vascular resistance | baseline, 1 year | Pulmonary vascular resistance by right heart catheterization |
| Secondary | Re-hospitalization due to clinical worsening | baseline, 3 years | Re-hospitalization is defined as clinical manifestations of worsening PAH requiring re-hospitalization in order to add intravenous pharmacological agents (inotrope or vasodilator), mechanical intervention or ultrafiltration, hemofiltration, or dialysis. |
| Secondary | All-cause mortality | baseline, 3 years | |
| Secondary | 6-Minute-walking Test | baseline, 1 year | |
| Secondary | Right atrial pressure by right heart catheterization | baseline, 1 year | |
| Secondary | Cardiac output (CO) by right heart catheterization | baseline, 1 year | |
| Secondary | Cardiac index (CI) by right heart catheterization | baseline, 1 year | |
| Secondary | RA-area (right atrial area) by echocardiography | baseline, 1 year | |
| Secondary | RV-area (right ventricular area) by echocardiography | baseline, 1 year |
1 to 10 of 13Source ClinicalTrials.gov
See all 13 registered outcomesOutcomes0
Each outcome the trial posted results for, in ClinicalTrials.gov's words.
None in this release.
Results by group0
Each measurement the trial posted, group by group, in the words and numbers it posted.
None in this release.
Participant flow0
How many started, completed or left each group, period by period.
None in this release.
Adverse events0
Each adverse event the trial posted, group by group: the participants affected out of those at risk.
None in this release.
Adverse event totals0
The totals the trial posted for each group.
None in this release.
Papers0
The papers the trial lists on ClinicalTrials.gov.
None in this release.
Grants0
The grants NIH RePORTER links to the trial, newest funded first: NIH's, and some of AHRQ's, CDC's, FDA's and VA's. Each shows its title, principal investigators, organization and funder in its newest year.
None in this release.
Trial comparisons0
Comparisons of the trial's two groups, calculated by ConductScience from the counts it posted.
None in this release.
Tests0
The ConductCognition tests this trial's registered outcomes name, as ScienceGraph matched them in trial-tests-2026-11-12-0.2.1.
None in this release.
Data dates
The day each source was copied for this release.
Sources 3
- ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
- ClinicalTrials.govNo license stated
- NIH RePORTER's clinical studies and project filesPublic domain
Each source's terms
- ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
- ClinicalTrials.govnone stated
- NIH RePORTER's clinical studies and project filesPublic domain (NIH RePORTER)
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.
For software
Read this trial from software.
The record and each of its lists are JSON, twenty rows a page. No key.
GET https://conductscience.org/api/trials/v1/NCT04972656
GET https://conductscience.org/api/trials/v1/NCT04972656/registered