Trial · NCT05018728
The Effect of Voxelotor on Cerebral Hemodynamic Response in Children With Sickle Cell Anemia
NCT05018728, Phase 2, Terminated, Emory University
3 sourcestrials-2026-11-12-0.5.0
Cite this record
ConductScience Library. The Effect of Voxelotor on Cerebral Hemodynamic Response in Children With Sickle Cell Anemia. Trials, record NCT05018728. Release trials-2026-11-12-0.5.0, 12 Nov 2026. https://conductscience.org/library/trials/NCT05018728
On this page
Trial
As registered on ClinicalTrials.gov, in the graph's capture of the registry.
- Title
- The Effect of Voxelotor on Cerebral Hemodynamic Response in Children With Sickle Cell Anemia
- NCT number
- NCT05018728
- Status
- Terminated
- Phases
- Phase 2
- Enrollment
- 22 participants, actual
- Lead sponsor
- Emory University
- Conditions
- Sickle Cell Anemia in Children
- Interventions
- Voxelotor
- First posted
- 2021-08-24
- Last updated
- 2025-12-12
Source ClinicalTrials.gov
Registered outcomes5
Each outcome the trial registered, primary first, in ClinicalTrials.gov's words.
| List | Outcome | Time frame | Description |
|---|---|---|---|
| Primary | Change in cerebral blood flow (CBF) | Baseline, Weeks 4 and 12 | CBF will be measured by diffuse correlation spectroscopy and frequency domain near-infrared spectroscopy (DCS/FDNIRS). |
| Primary | Change in oxygen extraction fraction (OEF) | Baseline, Weeks 4 and 12 | OEF will be measured by DCS/FDNIRS. OEF is defined as the difference between arterial and venous oxygen content and it increases to keep up with metabolic demand. |
| Primary | Change in cerebral metabolic rate of oxygen (CMRO2) | Baseline, Weeks 4 and 12 | CMRO2 will be measured by DCS/FDNIRS. CMRO2 is the rate that the brain consumes oxygen and is a marker of brain health. |
| Secondary | Change in total hemoglobin | Baseline, Weeks 4 and 12 | Total hemoglobin levels will be assessed and the correlation between changes in CBF, OEF and CMRO2 and change in hemoglobin at 4 and 12 weeks will be evaluated. |
| Secondary | Change in RBC content of voxelotor-modified hemoglobin | Baseline, Weeks 4 and 12 | RBC levels in voxelotor-modified hemoglobin will be assessed and the correlation between changes in CBF, OEF and CMRO2 and change in voxelotor-modified hemoglobin at 4 and 12 weeks will be evaluated. |
Source ClinicalTrials.gov
Outcomes0
Each outcome the trial posted results for, in ClinicalTrials.gov's words.
None in this release.
Results by group0
Each measurement the trial posted, group by group, in the words and numbers it posted.
None in this release.
Participant flow0
How many started, completed or left each group, period by period.
None in this release.
Adverse events0
Each adverse event the trial posted, group by group: the participants affected out of those at risk.
None in this release.
Adverse event totals0
The totals the trial posted for each group.
None in this release.
Papers1
The papers the trial lists on ClinicalTrials.gov.
| PMID | Listed as |
|---|---|
| 38364110 | DERIVED |
Source PubMed
Grants0
The grants NIH RePORTER links to the trial, newest funded first: NIH's, and some of AHRQ's, CDC's, FDA's and VA's. Each shows its title, principal investigators, organization and funder in its newest year.
None in this release.
Trial comparisons0
Comparisons of the trial's two groups, calculated by ConductScience from the counts it posted.
None in this release.
Tests0
The ConductCognition tests this trial's registered outcomes name, as ScienceGraph matched them in trial-tests-2026-11-12-0.2.1.
None in this release.
Data dates
The day each source was copied for this release.
Sources 3
- ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
- ClinicalTrials.govNo license stated
- NIH RePORTER's clinical studies and project filesPublic domain
Each source's terms
- ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
- ClinicalTrials.govnone stated
- NIH RePORTER's clinical studies and project filesPublic domain (NIH RePORTER)
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.
For software
Read this trial from software.
The record and each of its lists are JSON, twenty rows a page. No key.
GET https://conductscience.org/api/trials/v1/NCT05018728
GET https://conductscience.org/api/trials/v1/NCT05018728/registered