Trial · NCT05057221
Registered outcomes14
Each outcome the trial registered, primary first, in ClinicalTrials.gov's words.
1 to 14 of 14
Download this page as JSON| List | Outcome | Time frame | Description |
|---|---|---|---|
| Primary | Safety of Uproleselan - as Measured by Serious Adverse Events | Up to 28 days | Descriptive statistics will be calculated for quantitative safety data |
| Primary | Safety of Uproleselan- as Measured by Frequency of Serious Adverse Events | Up to 28 days | Frequency counts will be compiled for classification of qualitative safety data. |
| Secondary | Change in the Progression to Acute Respiratory Failure for Patients With a Baseline PaO2/FiO2 >= 200 | Enrollment, 15 days | Patients with a baseline PaO2/FiO2 \>= 200: progression of respiratory failure is defined by: 1. severe gas transfer deficit (PaO2/FiO2 \< 200); 2. persistent respiratory distress while receiving oxygen (persistent marked dyspnea, use of accessory respiratory muscles, paradoxical respiratory movements); The rate will be calculated as the proportion of patients who experienced at least one of the events above by day+15 from treatment start. |
| Secondary | Number of Patients Alive Who Are Free of Respiratory Failure | Up to 28 days | Number of patients alive and free of acute respiratory failure which required initiation of mechanical ventilation |
| Secondary | All-cause Mortality | Up to 28 days | All-cause hospital mortality |
| Secondary | Time to Change Oxygenation | during hospitalization; hospital stay ranged from 2 to 10 days | Number of days it took to reduce their oxygen requirements |
| Secondary | Number of Patients Requiring Mechanical Ventilation | Up to 28 days | Number of patients requiring mechanical ventilation |
| Secondary | Change in the World Health Organization (WHO) COVID-19, "8-point Ordinal Scale" as Shown by Presenting Selected Time Points Through Day 28 | Enrollment, day 28 | WHO COVID-19, "8-point ordinal scale" has a range of 1-8 with higher numbers indicating a more severe disease. |
| Secondary | Actual Duration of Hospitalization | Up to 28 days | Duration of hospitalization - number of inpatient hospital days. Participants were planned to be followed for up to 28 days, although the longest actual hospital stay for a participant was 10 days. |
| Secondary | Actual Duration of ICU Care | Up to 28 days | Duration of ICU stay - number of ICU days. Participants were planned to be followed for up to 28 days, although the longest actual hospital stay for a participant was 10 days. |
| Secondary | Participants Who Experienced Grade 3-4 Hemorrhagic Events | Up to 28 days | Number of participants who experienced a Grade 3 or Grade 4 hemorrhagic event based on the World Health Organization's (WHO) Bleeding Scale. On the scale, a Grade 3 event means gross blood loss, and a Grade 4 event means debilitating blood loss. |
| Secondary | Change in E-selectin Plasma Concentrations, as Shown by Values for Each of Those Days | 6 Days | Changes in E-selectin plasma concentrations measured each day for 6 days. |
| Secondary | Participants Who Experienced Venous Thromboembolism (Deep Venous Thrombosis or Pulmonary Embolism) | Enrollment, up to day 28 | Venous thromboembolism - DVT or PE |
| Secondary | Number of Mechanical Ventilation and Vasopressor Days | Up to Day 28 | Days of mechanical ventilation and days of vasopressors |
Source ClinicalTrials.govtrials-2026-11-12-0.5.0
Sources 3
- ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
- ClinicalTrials.govNo license stated
- NIH RePORTER's clinical studies and project filesPublic domain
Each source's terms
- ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
- ClinicalTrials.govnone stated
- NIH RePORTER's clinical studies and project filesPublic domain (NIH RePORTER)
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.
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GET https://conductscience.org/api/trials/v1/NCT05057221/registered