Trial · NCT05079620
Early Antibiotics After Aspiration in ICU Patients
NCT05079620, Phase 4, Terminated, UConn Health; results first posted 2025-12-30
3 sourcestrials-2026-11-12-0.5.0
Cite this record
ConductScience Library. Early Antibiotics After Aspiration in ICU Patients. Trials, record NCT05079620. Release trials-2026-11-12-0.5.0, 12 Nov 2026. https://conductscience.org/library/trials/NCT05079620
On this page
Trial
As registered on ClinicalTrials.gov, in the graph's capture of the registry.
- Title
- Early Antibiotics After Aspiration in ICU Patients
- NCT number
- NCT05079620
- Status
- Terminated
- Phases
- Phase 4
- Enrollment
- 5 participants, actual
- Lead sponsor
- UConn Health
- Conditions
- Aspiration, Aspiration Pneumonia
- Interventions
- Ceftriaxone, Amoxicillin clavulanic acid, Cefepime, Vancomycin, Levofloxacin
- First posted
- 2021-10-15
- Last updated
- 2025-12-30
- Results first posted
- 2025-12-30
Source ClinicalTrials.gov
Registered outcomes17
Each outcome the trial registered, primary first, in ClinicalTrials.gov's words.
| List | Outcome | Time frame | Description |
|---|---|---|---|
| Primary | ICU-free Days | From admission to 30 days, death, or hospital discharge, whichever occurs first | Number of days not spent in the ICU, between date of admission and 30 days afterwards. Death or discharge can both reduce this measure. |
| Secondary | Ventilator-free Days | From admission to 30 days, death, or hospital discharge, whichever occurs first | Number of days without any mechanical ventilation, between date of admission and 30 days afterwards. Death, discharge, or mechanical ventilation can both reduce this measure. |
| Secondary | Hospital-free Days | From admission to 30 days, death, or hospital discharge, whichever occurs first | Number of days not spent in the hospital, between date of admission and 30 days afterwards. Death or discharge can both reduce this measure. |
| Secondary | Antibiotic-free Days | Days with no antibiotics from admission to 30 days, death, or hospital discharge, whichever occurs first | Number of days without any antibiotics administered, between date of admission and 30 days afterwards. Death, discharge, or antibiotic use can all reduce this measure. |
| Secondary | Number of Participants Intubated After Enrollment | Between admission to 30 days, death, or hospital discharge, whichever occurs first | Yes/no |
| Secondary | Number of Participants Who Underwent Tracheostomy After Enrollment | Between admission to 30 days, death, or hospital discharge, whichever occurs first | Yes/no |
| Secondary | Number of Participants Who Developed Pneumonia After Enrollment | Between admission to 30 days, death, or hospital discharge, whichever occurs first | Yes/no, by criteria: 2 or more present simultaneously of temperature \>38c, WBC \>11k, S/F ratio \<215, and purulent secretions |
| Secondary | Days Before Developing Pneumonia Criteria | Between admission to 30 days, death, or hospital discharge, whichever occurs first | By criteria: 2 or more present simultaneously of temperature \>38c, WBC \>11k, S/F ratio \<215, and purulent secretions |
| Secondary | Number of Participants Prescribed Additional Antibiotics After Enrollment | Between admission to 30 days, death, or hospital discharge, whichever occurs first | Yes/no. Excluding prophylactic antibiotics and excluding perioperative prophylactic antibiotics. |
| Secondary | Number of Participants With a Positive Sputum Culture With a Presumed Pathogen | Between enrollment and 30 days, death, or hospital discharge, whichever occurs first | Yes/no |
1 to 10 of 17Source ClinicalTrials.gov
See all 17 registered outcomesOutcomes17
Each outcome the trial posted results for, in ClinicalTrials.gov's words.
| Type | Outcome | Time frame | Population | Units | Measured as |
|---|---|---|---|---|---|
| PRIMARY | ICU-free Days | From admission to 30 days, death, or hospital discharge, whichever occurs first | days | MEAN | |
| SECONDARY | Ventilator-free Days | From admission to 30 days, death, or hospital discharge, whichever occurs first | days | MEAN | |
| SECONDARY | Hospital-free Days | From admission to 30 days, death, or hospital discharge, whichever occurs first | days | MEAN | |
| SECONDARY | Antibiotic-free Days | Days with no antibiotics from admission to 30 days, death, or hospital discharge, whichever occurs first | days | MEAN | |
| SECONDARY | Number of Participants Intubated After Enrollment | Between admission to 30 days, death, or hospital discharge, whichever occurs first | Participants | COUNT_OF_PARTICIPANTS | |
| SECONDARY | Number of Participants Who Underwent Tracheostomy After Enrollment | Between admission to 30 days, death, or hospital discharge, whichever occurs first | Participants | COUNT_OF_PARTICIPANTS | |
| SECONDARY | Number of Participants Who Developed Pneumonia After Enrollment | Between admission to 30 days, death, or hospital discharge, whichever occurs first | Participants | COUNT_OF_PARTICIPANTS | |
| SECONDARY | Days Before Developing Pneumonia Criteria | Between admission to 30 days, death, or hospital discharge, whichever occurs first | days | MEAN | |
| SECONDARY | Number of Participants Prescribed Additional Antibiotics After Enrollment | Between admission to 30 days, death, or hospital discharge, whichever occurs first | Participants | COUNT_OF_PARTICIPANTS | |
| SECONDARY | Number of Participants With a Positive Sputum Culture With a Presumed Pathogen | Between enrollment and 30 days, death, or hospital discharge, whichever occurs first | Participants | COUNT_OF_PARTICIPANTS |
1 to 10 of 17Source ClinicalTrials.gov
See all 17 outcomesResults by group34
Each measurement the trial posted, group by group, in the words and numbers it posted.
| Outcome | Group | Category | Value | Spread | Units |
|---|---|---|---|---|---|
| ICU-free Days | Antibiotics | 14 | Standard Deviation 14.1 | days | |
| ICU-free Days | Control | 18.7 | Standard Deviation 16.1 | days | |
| Ventilator-free Days | Antibiotics | 19 | Standard Deviation 15.6 | days | |
| Ventilator-free Days | Control | 20 | Standard Deviation 17.3 | days | |
| Hospital-free Days | Antibiotics | 9 | Standard Deviation 12.7 | days | |
| Hospital-free Days | Control | 14.7 | Standard Deviation 13.7 | days | |
| Antibiotic-free Days | Antibiotics | 12 | Standard Deviation 17 | days | |
| Antibiotic-free Days | Control | 14 | Standard Deviation 14.5 | days | |
| Number of Participants Intubated After Enrollment | Antibiotics | 0 | Participants | ||
| Number of Participants Intubated After Enrollment | Control | 0 | Participants |
1 to 10 of 34Source ClinicalTrials.gov
See all 34 results by groupParticipant flow6
How many started, completed or left each group, period by period.
| Period | Milestone | Group | Participants | Units counted |
|---|---|---|---|---|
| Overall Study | STARTED | Antibiotics | 2 | |
| Overall Study | STARTED | Control | 3 | |
| Overall Study | COMPLETED | Antibiotics | 2 | |
| Overall Study | COMPLETED | Control | 3 | |
| Overall Study | NOT COMPLETED | Antibiotics | 0 | |
| Overall Study | NOT COMPLETED | Control | 0 |
Source ClinicalTrials.gov
Adverse events0
Each adverse event the trial posted, group by group: the participants affected out of those at risk.
None in this release.
Adverse event totals6
The totals the trial posted for each group.
| Total | Group | Affected | At risk |
|---|---|---|---|
| Total, all-cause mortality | Antibiotics | 1 | 2 |
| Total, all-cause mortality | Control | 0 | 3 |
| Total, other adverse events | Antibiotics | 0 | 2 |
| Total, other adverse events | Control | 0 | 3 |
| Total, serious adverse events | Antibiotics | 0 | 2 |
| Total, serious adverse events | Control | 0 | 3 |
Source ClinicalTrials.gov
Papers12
The papers the trial lists on ClinicalTrials.gov.
Grants0
The grants NIH RePORTER links to the trial, newest funded first: NIH's, and some of AHRQ's, CDC's, FDA's and VA's. Each shows its title, principal investigators, organization and funder in its newest year.
None in this release.
Trial comparisons14
Comparisons of the trial's two groups, calculated by ConductScience from the counts it posted.
| Comparison | Source |
|---|---|
| Antibiotics vs Control: Number of Participants With Purulent Secretions on Day 3 | Trial comparisons |
| Antibiotics vs Control: Number of Participants With a Positive C. Difficile Stool Toxin Assay After Enrollment | Trial comparisons |
| Antibiotics vs Control: Number of Participants With a Positive Sputum Culture With a Presumed Pathogen | Trial comparisons |
| Antibiotics vs Control: Number of Participants Prescribed Additional Antibiotics After Enrollment | Trial comparisons |
| Antibiotics vs Control: Number of Participants With Arterial Oxygen Saturation / Fraction of Inspired Oxygen (S/F) <215 on Day 3 | Trial comparisons |
| Antibiotics vs Control: Number of Participants Who Developed Pneumonia After Enrollment | Trial comparisons |
| Antibiotics vs Control: Number of Participants With a White Blood Cell Count >11k on Day 3 | Trial comparisons |
| Antibiotics vs Control: 30 Day Mortality | Trial comparisons |
| Antibiotics vs Control: Number of Participants Intubated After Enrollment | Trial comparisons |
| Antibiotics vs Control: Number of Participants Who Underwent Tracheostomy After Enrollment | Trial comparisons |
1 to 10 of 14
See all 14 trial comparisonsTests0
The ConductCognition tests this trial's registered outcomes name, as ScienceGraph matched them in trial-tests-2026-11-12-0.2.1.
None in this release.
Data dates
The day each source was copied for this release.
Sources 3
- ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
- ClinicalTrials.govNo license stated
- NIH RePORTER's clinical studies and project filesPublic domain
Each source's terms
- ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
- ClinicalTrials.govnone stated
- NIH RePORTER's clinical studies and project filesPublic domain (NIH RePORTER)
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.
For software
Read this trial from software.
The record and each of its lists are JSON, twenty rows a page. No key.
GET https://conductscience.org/api/trials/v1/NCT05079620
GET https://conductscience.org/api/trials/v1/NCT05079620/results?page=2