Trial · NCT05079789

Amiloride in Nephrotic Syndrome

NCT05079789, Phase 3, Terminated, University Hospital Tuebingen; results first posted 2025-01-14

3 sourcestrials-2026-11-12-0.5.0

Cite this record

ConductScience Library. Amiloride in Nephrotic Syndrome. Trials, record NCT05079789. Release trials-2026-11-12-0.5.0, 12 Nov 2026. https://conductscience.org/library/trials/NCT05079789

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Trial

As registered on ClinicalTrials.gov, in the graph's capture of the registry.

Title: Amiloride in Nephrotic Syndrome
NCT number: NCT05079789
Status: Terminated
Phases: Phase 3
Enrollment: 20 participants, actual
Lead sponsor: University Hospital Tuebingen
Conditions: Nephrotic Syndrome, Edema, Sodium Retention
Interventions: Amiloride, Furosemide
First posted: 2021-10-15
Last updated: 2025-01-14
Other registries' IDs: eudract:2019-002607-18
Results first posted: 2025-01-14

Source ClinicalTrials.gov

Registered outcomes3

Each outcome the trial registered, primary first, in ClinicalTrials.gov's words.

List	Outcome	Time frame	Description
Primary	Decrease of Overhydration, %ECW After 8 Days	8 days	Decrease of overhydration (OH) measured by bioimpedance spectroscopy, expressed as percent of extracellular water (%ECW)
Secondary	Decrease of Overhydration, %ECW After 16 Days	16 days	Decrease of overhydration (OH) measured by bioimpedance spectroscopy, expressed as percent of extracellular water (%ECW)
Secondary	Decrease of Body Weight, kg	8 days	Decrease of body weight after 8 days

Source ClinicalTrials.gov

Outcomes3

Each outcome the trial posted results for, in ClinicalTrials.gov's words.

Type	Outcome	Time frame	Units	Measured as
PRIMARY	Decrease of Overhydration, %ECW After 8 Days	8 days	%ECW	MEDIAN
SECONDARY	Decrease of Overhydration, %ECW After 16 Days	16 days	%ECW	MEDIAN
SECONDARY	Decrease of Body Weight, kg	8 days	kg	MEDIAN

Source ClinicalTrials.gov

Results by group6

Each measurement the trial posted, group by group, in the words and numbers it posted.

Outcome	Group	Value	Spread	Units
Decrease of Overhydration, %ECW After 8 Days	Amiloride	1.95	Inter-Quartile Range 0.80 to 6.40	%ECW
Decrease of Overhydration, %ECW After 8 Days	Furosemide	5.15	Inter-Quartile Range 0.90 to 8.30	%ECW
Decrease of Overhydration, %ECW After 16 Days	Amiloride	10.10	Inter-Quartile Range 1.30 to 14.40	%ECW
Decrease of Overhydration, %ECW After 16 Days	Furosemide	7.40	Inter-Quartile Range 2.80 to 10.10	%ECW
Decrease of Body Weight, kg	Amiloride	3.8	Inter-Quartile Range 1.7 to 7.2	kg
Decrease of Body Weight, kg	Furosemide	2.0	Inter-Quartile Range 1.5 to 4.6	kg

Source ClinicalTrials.gov

Participant flow6

How many started, completed or left each group, period by period.

Period	Milestone	Group	Participants
Overall Study	STARTED	Amiloride	10
Overall Study	STARTED	Furosemide	10
Overall Study	COMPLETED	Amiloride	10
Overall Study	COMPLETED	Furosemide	10
Overall Study	NOT COMPLETED	Amiloride	0
Overall Study	NOT COMPLETED	Furosemide	0

Source ClinicalTrials.gov

Adverse events32

Each adverse event the trial posted, group by group: the participants affected out of those at risk.

Type	Event	Organ system	Group	Affected	At risk	Events
other	planned hospitalization for kidney biopsy	Surgical and medical procedures	Amiloride	2	10	2
other	planned hospitalization for kidney biopsy	Surgical and medical procedures	Furosemide	3	10	3
other	dizziness	Nervous system disorders	Amiloride	0	10	0
other	dizziness	Nervous system disorders	Furosemide	1	10	1
other	headache	Nervous system disorders	Amiloride	0	10	0
other	headache	Nervous system disorders	Furosemide	1	10	1
other	nausea	Gastrointestinal disorders	Amiloride	2	10	2
other	nausea	Gastrointestinal disorders	Furosemide	0	10	0
other	epistaxis	Respiratory, thoracic and mediastinal disorders	Amiloride	1	10	1
other	epistaxis	Respiratory, thoracic and mediastinal disorders	Furosemide	1	10	1

1 to 10 of 32Source ClinicalTrials.gov

See all 32 adverse events

Adverse event totals6

The totals the trial posted for each group.

Total	Group	Affected	At risk
Total, all-cause mortality	Amiloride	0	10
Total, all-cause mortality	Furosemide	0	10
Total, other adverse events	Amiloride	9	10
Total, other adverse events	Furosemide	10	10
Total, serious adverse events	Amiloride	1	10
Total, serious adverse events	Furosemide	4	10

Source ClinicalTrials.gov

Papers1

The papers the trial lists on ClinicalTrials.gov.

PMID	Listed as
30597733	BACKGROUND

Source PubMed

Grants0

The grants NIH RePORTER links to the trial, newest funded first: NIH's, and some of AHRQ's, CDC's, FDA's and VA's. Each shows its title, principal investigators, organization and funder in its newest year.

None in this release.

Trial comparisons2

Comparisons of the trial's two groups, calculated by ConductScience from the counts it posted.

Comparison	Source
Amiloride vs Furosemide: deaths from any cause	Trial comparisons
Amiloride vs Furosemide: serious adverse events	Trial comparisons

Tests0

The ConductCognition tests this trial's registered outcomes name, as ScienceGraph matched them in trial-tests-2026-11-12-0.2.1.

None in this release.

Data dates

The day each source was copied for this release.

ClinicalTrials.gov: 2026-11-12; ClinicalTrials.gov
Results, from AACT: 2026-03-23; AACT
NIH grant links: 2026-11-13; NIH RePORTER

Sources 3

ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
ClinicalTrials.govNo license stated
NIH RePORTER's clinical studies and project filesPublic domain

Each source's terms

ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
ClinicalTrials.govnone stated
NIH RePORTER's clinical studies and project filesPublic domain (NIH RePORTER)

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

For software

Read this trial from software.

The record and each of its lists are JSON, twenty rows a page. No key.

GET https://conductscience.org/api/trials/v1/NCT05079789

GET https://conductscience.org/api/trials/v1/NCT05079789/events?page=2

API reference For AI assistants