Trial · NCT05082909
Addition of Probenecid to Penicillin-V Therapy
NCT05082909, Phase 1, Phase 2, Completed, Imperial College London; results first posted 2025-01-30
3 sourcestrials-2026-11-12-0.5.0
Cite this record
ConductScience Library. Addition of Probenecid to Penicillin-V Therapy. Trials, record NCT05082909. Release trials-2026-11-12-0.5.0, 12 Nov 2026. https://conductscience.org/library/trials/NCT05082909
On this page
Trial
As registered on ClinicalTrials.gov, in the graph's capture of the registry.
- Title
- Addition of Probenecid to Penicillin-V Therapy
- NCT number
- NCT05082909
- Status
- Completed
- Phases
- Phase 1, Phase 2
- Enrollment
- 21 participants, actual
- Lead sponsor
- Imperial College London
- Conditions
- Infection, Bacterial
- Interventions
- Probenecid
- First posted
- 2021-10-19
- Last updated
- 2025-01-30
- Results first posted
- 2025-01-30
Source ClinicalTrials.gov
Registered outcomes4
Each outcome the trial registered, primary first, in ClinicalTrials.gov's words.
| List | Outcome | Time frame | Description |
|---|---|---|---|
| Primary | Measurement of Total and Unbound Penicillin-V Concentration | 45 minutes post an observed dose. | Measurement of blood concentration at 45 minutes post dose with and without probenecid. |
| Primary | Measurement of Total and Unbound Penicillin-V Concentration | 180 minutes post an observed dose. | Measurement of blood concentration at 180 minutes post dose with and without probenecid. |
| Secondary | Measurement of Total and Unbound Probenecid Concentration | 45 minutes post an observed dose. | Measurement of blood concentration at 45 minutes post observed probenecid dose. Combined data for all participants given that the same dose of probenecid was taken by all participants. |
| Secondary | Measurement of Total and Unbound Probenecid Concentration | 180 minutes post an observed dose. | Measurement of blood concentration at 180 minutes post observed probenecid dose. Combined data for all participants given that the same dose of probenecid was taken by all participants. |
Source ClinicalTrials.gov
Outcomes4
Each outcome the trial posted results for, in ClinicalTrials.gov's words.
| Type | Outcome | Time frame | Population | Units | Measured as |
|---|---|---|---|---|---|
| PRIMARY | Measurement of Total and Unbound Penicillin-V Concentration | 45 minutes post an observed dose. | mg/L | MEAN | |
| PRIMARY | Measurement of Total and Unbound Penicillin-V Concentration | 180 minutes post an observed dose. | mg/L | MEAN | |
| SECONDARY | Measurement of Total and Unbound Probenecid Concentration | 45 minutes post an observed dose. | All 20 participants received the same dose (500mg QDS) of probenecid regardless of study arm. Results are therefore presented for all participants for this outcome. | mg/L | MEAN |
| SECONDARY | Measurement of Total and Unbound Probenecid Concentration | 180 minutes post an observed dose. | All 20 participants received the same dose (500mg QDS) of probenecid regardless of study arm. Results are therefore presented for all participants for this outcome. | mg/L | MEAN |
Source ClinicalTrials.gov
Results by group52
Each measurement the trial posted, group by group, in the words and numbers it posted.
| Outcome | Group | Category | Value | Spread | Units |
|---|---|---|---|---|---|
| Measurement of Total and Unbound Penicillin-V Concentration | 250mg Penicillin Arm 1 | Total penicillin concentration (mg/L) - penicillin alone | 2.07 | Standard Deviation 0.16 | mg/L |
| Measurement of Total and Unbound Penicillin-V Concentration | 250mg Penicillin Arm 2 | Total penicillin concentration (mg/L) - penicillin alone | 2.8 | Standard Deviation 0.10 | mg/L |
| Measurement of Total and Unbound Penicillin-V Concentration | 500mg Penicillin Arm 1 | Total penicillin concentration (mg/L) - penicillin alone | 5.03 | Standard Deviation 1.46 | mg/L |
| Measurement of Total and Unbound Penicillin-V Concentration | 500mg Penicillin Arm 2 | Total penicillin concentration (mg/L) - penicillin alone | 3.62 | Standard Deviation 1.56 | mg/L |
| Measurement of Total and Unbound Penicillin-V Concentration | 750mg Penicillin Arm 1 | Total penicillin concentration (mg/L) - penicillin alone | 6.53 | Standard Deviation 5.38 | mg/L |
| Measurement of Total and Unbound Penicillin-V Concentration | 750mg Penicillin Arm 2 | Total penicillin concentration (mg/L) - penicillin alone | 6.2 | Standard Deviation 0.8 | mg/L |
| Measurement of Total and Unbound Penicillin-V Concentration | 250mg Penicillin Arm 1 | Unbound penicillin concentration (mg/L) - penicillin alone | 0.39 | Standard Deviation 0.04 | mg/L |
| Measurement of Total and Unbound Penicillin-V Concentration | 250mg Penicillin Arm 2 | Unbound penicillin concentration (mg/L) - penicillin alone | 0.56 | Standard Deviation 0.01 | mg/L |
| Measurement of Total and Unbound Penicillin-V Concentration | 500mg Penicillin Arm 1 | Unbound penicillin concentration (mg/L) - penicillin alone | 0.97 | Standard Deviation 0.22 | mg/L |
| Measurement of Total and Unbound Penicillin-V Concentration | 500mg Penicillin Arm 2 | Unbound penicillin concentration (mg/L) - penicillin alone | 0.65 | Standard Deviation 0.27 | mg/L |
1 to 10 of 52Source ClinicalTrials.gov
See all 52 results by groupParticipant flow18
How many started, completed or left each group, period by period.
| Period | Milestone | Group | Participants | Units counted |
|---|---|---|---|---|
| Overall Study | STARTED | Penicillin 250mg QDS THEN Penicillin 250mg QDS Plus Probenecid 500mg QDS | 3 | |
| Overall Study | STARTED | Penicillin 500mg QDS THEN Penicillin 500mg QDS Plus Probenecid 500mg QDS | 4 | |
| Overall Study | STARTED | Penicillin 750mg QDS THEN Penicillin 750mg QDS Plus Probenecid 500mg QDS | 4 | |
| Overall Study | STARTED | Penicillin 250mg QDS Plus Probenecid 500mg QDS THEN Penicillin 250mg QDS. | 2 | |
| Overall Study | STARTED | Penicillin 500mg QDS Plus Probenecid 500mg QDS THEN Penicillin 500mg QDS. | 6 | |
| Overall Study | STARTED | Penicillin 750mg QDS Plus Probenecid 500mg QDS THEN Penicillin 750mg QDS. | 2 | |
| Overall Study | COMPLETED | Penicillin 250mg QDS THEN Penicillin 250mg QDS Plus Probenecid 500mg QDS | 3 | |
| Overall Study | COMPLETED | Penicillin 500mg QDS THEN Penicillin 500mg QDS Plus Probenecid 500mg QDS | 4 | |
| Overall Study | COMPLETED | Penicillin 750mg QDS THEN Penicillin 750mg QDS Plus Probenecid 500mg QDS | 3 | |
| Overall Study | COMPLETED | Penicillin 250mg QDS Plus Probenecid 500mg QDS THEN Penicillin 250mg QDS. | 2 |
1 to 10 of 18Source ClinicalTrials.gov
See all 18 participant flowAdverse events10
Each adverse event the trial posted, group by group: the participants affected out of those at risk.
| Type | Event | Organ system | Group | Affected | At risk | Events |
|---|---|---|---|---|---|---|
| other | Mild, expected (GI side effects) | Gastrointestinal disorders | Penicillin Alone | 3 | 20 | 4 |
| other | Mild, expected (GI side effects) | Gastrointestinal disorders | Penicillin Plus Probenecid | 5 | 20 | 7 |
| other | Mild, expected (headache) | Nervous system disorders | Penicillin Alone | 1 | 20 | 1 |
| other | Mild, expected (headache) | Nervous system disorders | Penicillin Plus Probenecid | 3 | 20 | 3 |
| other | Unexpected, not related to IMP | Infections and infestations | Penicillin Alone | 1 | 20 | 1 |
| other | Unexpected, not related to IMP | Infections and infestations | Penicillin Plus Probenecid | 0 | 20 | 0 |
| other | Unexpected, not related to IMP | Musculoskeletal and connective tissue disorders | Penicillin Alone | 1 | 20 | 1 |
| other | Unexpected, not related to IMP | Musculoskeletal and connective tissue disorders | Penicillin Plus Probenecid | 0 | 20 | 0 |
| other | Unexpected, possible association with IMP | Metabolism and nutrition disorders | Penicillin Alone | 1 | 20 | 1 |
| other | Unexpected, possible association with IMP | Metabolism and nutrition disorders | Penicillin Plus Probenecid | 0 | 20 | 0 |
Source ClinicalTrials.gov
Adverse event totals6
The totals the trial posted for each group.
| Total | Group | Affected | At risk |
|---|---|---|---|
| Total, all-cause mortality | Penicillin Alone | 0 | 20 |
| Total, all-cause mortality | Penicillin Plus Probenecid | 0 | 20 |
| Total, other adverse events | Penicillin Alone | 7 | 20 |
| Total, other adverse events | Penicillin Plus Probenecid | 8 | 20 |
| Total, serious adverse events | Penicillin Alone | 0 | 20 |
| Total, serious adverse events | Penicillin Plus Probenecid | 0 | 20 |
Source ClinicalTrials.gov
Papers0
The papers the trial lists on ClinicalTrials.gov.
None in this release.
Grants0
The grants NIH RePORTER links to the trial, newest funded first: NIH's, and some of AHRQ's, CDC's, FDA's and VA's. Each shows its title, principal investigators, organization and funder in its newest year.
None in this release.
Trial comparisons2
Comparisons of the trial's two groups, calculated by ConductScience from the counts it posted.
| Comparison | Source |
|---|---|
| Penicillin Alone vs Penicillin Plus Probenecid: deaths from any cause | Trial comparisons |
| Penicillin Alone vs Penicillin Plus Probenecid: serious adverse events | Trial comparisons |
Tests0
The ConductCognition tests this trial's registered outcomes name, as ScienceGraph matched them in trial-tests-2026-11-12-0.2.1.
None in this release.
Data dates
The day each source was copied for this release.
Sources 3
- ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
- ClinicalTrials.govNo license stated
- NIH RePORTER's clinical studies and project filesPublic domain
Each source's terms
- ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
- ClinicalTrials.govnone stated
- NIH RePORTER's clinical studies and project filesPublic domain (NIH RePORTER)
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.
For software
Read this trial from software.
The record and each of its lists are JSON, twenty rows a page. No key.
GET https://conductscience.org/api/trials/v1/NCT05082909
GET https://conductscience.org/api/trials/v1/NCT05082909/results?page=2