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Trial · NCT05089084

Results by group158

Each measurement the trial posted, group by group, in the words and numbers it posted.

OutcomeGroupCategoryValueSpreadUnits
Percent Change From Baseline at Month 10 in Fasting Triglycerides (TG)Placebo (Pooled)-17.1Inter-Quartile Range -49.1 to 47.0percentage change
Percent Change From Baseline at Month 10 in Fasting Triglycerides (TG)ARO-APOC3 (Plozasiran) 25 mg-80.1Inter-Quartile Range -89.9 to -61.0percentage change
Percent Change From Baseline at Month 10 in Fasting Triglycerides (TG)ARO-APOC3 (Plozasiran) 50 mg-77.6Inter-Quartile Range -87.7 to -48.6percentage change
Percent Change From Baseline in Fasting TG at Month 10 and Month 12 (Averaged)Placebo (Pooled)-2.6Inter-Quartile Range -45.0 to 33.3percentage change
Percent Change From Baseline in Fasting TG at Month 10 and Month 12 (Averaged)ARO-APOC3 (Plozasiran) 25 mg-77.7Inter-Quartile Range -89.0 to -59.2percentage change
Percent Change From Baseline in Fasting TG at Month 10 and Month 12 (Averaged)ARO-APOC3 (Plozasiran) 50 mg-71.0Inter-Quartile Range -86.7 to -52.6percentage change
Percent Change From Baseline in Apolipoprotein C-III (APOC3) at Month 10Placebo (Pooled)-1.25Inter-Quartile Range -16.59 to 26.46percentage change
Percent Change From Baseline in Apolipoprotein C-III (APOC3) at Month 10ARO-APOC3 (Plozasiran) 25 mg-92.95Inter-Quartile Range -97.58 to -87.86percentage change
Percent Change From Baseline in Apolipoprotein C-III (APOC3) at Month 10ARO-APOC3 (Plozasiran) 50 mg-96.20Inter-Quartile Range -97.71 to -89.88percentage change
Percent Change From Baseline in Fasting APOC3 at Month 12Placebo (Pooled)7.69Inter-Quartile Range -33.65 to 31.28percentage change
Percent Change From Baseline in Fasting APOC3 at Month 12ARO-APOC3 (Plozasiran) 25 mg-89.30Inter-Quartile Range -93.84 to -80.24percentage change
Percent Change From Baseline in Fasting APOC3 at Month 12ARO-APOC3 (Plozasiran) 50 mg-87.73Inter-Quartile Range -93.01 to -78.70percentage change
Percentage of Participants With Positively Adjudicated Events of Acute Pancreatitis (Randomized Period)Placebo (Pooled)20.0percentage of participants
Percentage of Participants With Positively Adjudicated Events of Acute Pancreatitis (Randomized Period)ARO-APOC3 (Plozasiran) Pooled4.0percentage of participants
Percent Change From Baseline in Non-High Density Lipoprotein Cholesterol (Non-HDL-C) at Month 10Placebo (Pooled)3.67Standard Error 9.454percentage change
Percent Change From Baseline in Non-High Density Lipoprotein Cholesterol (Non-HDL-C) at Month 10ARO-APOC3 (Plozasiran) 25 mg-38.69Standard Error 7.980percentage change
Percent Change From Baseline in Non-High Density Lipoprotein Cholesterol (Non-HDL-C) at Month 10ARO-APOC3 (Plozasiran) 50 mg-36.12Standard Error 8.351percentage change
Percent Change From Baseline in Non-HDL-C at Month 12Placebo (Pooled)6.72Standard Error 9.373percentage change
Percent Change From Baseline in Non-HDL-C at Month 12ARO-APOC3 (Plozasiran) 25 mg-38.16Standard Error 7.928percentage change
Percent Change From Baseline in Non-HDL-C at Month 12ARO-APOC3 (Plozasiran) 50 mg-25.48Standard Error 8.368percentage change

Source ClinicalTrials.govtrials-2026-11-12-0.5.0

Sources 3

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ClinicalTrials.govNo license stated
  • NIH RePORTER's clinical studies and project filesPublic domain
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ClinicalTrials.govnone stated
  • NIH RePORTER's clinical studies and project filesPublic domain (NIH RePORTER)

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

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