Trial · NCT05146089
Reflex Responses to Intermittent Hypoxia in Humans: Mechanisms and Consequences
NCT05146089, Early phase 1, Completed, University of Missouri-Columbia
3 sourcestrials-2026-11-12-0.4.0
Cite this record
ConductScience Library. Reflex Responses to Intermittent Hypoxia in Humans: Mechanisms and Consequences. Trials, record NCT05146089. Release trials-2026-11-12-0.4.0, 12 Nov 2026. https://conductscience.org/library/trials/NCT05146089
On this page
Trial
As registered on ClinicalTrials.gov, in the graph's capture of the registry.
- Title
- Reflex Responses to Intermittent Hypoxia in Humans: Mechanisms and Consequences
- NCT number
- NCT05146089
- Status
- Completed
- Phases
- Early phase 1
- Enrollment
- 54 participants, actual
- Lead sponsor
- University of Missouri-Columbia
- Conditions
- Sleep Apnea, Healthy, Vasoconstriction, Vasodilation
- Interventions
- Hypoxic exposure, modified Oxford test, Oral Bosentan 62.5 mg, Hypoxic ventilatory response test
- First posted
- 2021-12-06
- Last updated
- 2021-12-06
Source ClinicalTrials.gov
Registered outcomes2
Each outcome the trial registered, primary first, in ClinicalTrials.gov's words.
| List | Outcome | Time frame | Description |
|---|---|---|---|
| Primary | Muscle sympathetic nerve activity (MSNA) | Change from baseline after hypoxia exposure | MSNA burst incidence (bursts/100 heart beats) |
| Secondary | Arterial blood pressure | Change from baseline after hypoxia exposure | Systolic blood pressure, Diastolic blood pressure, Mean blood pressure |
Source ClinicalTrials.gov
Outcomes0
Each outcome the trial posted results for, in ClinicalTrials.gov's words.
None in this release.
Results by group0
Each measurement the trial posted, group by group, in the words and numbers it posted.
None in this release.
Participant flow0
How many started, completed or left each group, period by period.
None in this release.
Adverse events0
Each adverse event the trial posted, group by group: the participants affected out of those at risk.
None in this release.
Adverse event totals0
The totals the trial posted for each group.
None in this release.
Papers0
The papers the trial lists on ClinicalTrials.gov.
None in this release.
Grants2
The grants NIH RePORTER links to the trial, newest funded first: NIH's, and some of AHRQ's, CDC's, FDA's and VA's. Each shows its title, principal investigators, organization and funder in its newest year.
| Project | Title | Principal investigators | Organization | Funder | Fiscal years | Source |
|---|---|---|---|---|---|---|
| R00HL130339 | Reflex responses to intermittent hypoxia in humans: Mechanisms and consequences | LIMBERG, JACQUELINE K | UNIVERSITY OF MISSOURI-COLUMBIA | NATIONAL HEART, LUNG, AND BLOOD INSTITUTE | 2017 to 2019 | NIH RePORTER |
| K99HL130339 | Reflex responses to intermittent hypoxia in humans: Mechanisms and consequences | LIMBERG, JACQUELINE K | MAYO CLINIC ROCHESTER | NATIONAL HEART, LUNG, AND BLOOD INSTITUTE | 2016 to 2017 | NIH RePORTER |
Trial comparisons0
Comparisons of the trial's two groups, calculated by ConductScience from the counts it posted.
None in this release.
Tests0
The ConductCognition tests this trial's registered outcomes name, as ScienceGraph matched them in trial-tests-2026-11-12-0.2.1.
None in this release.
Source
- Release
- trials-2026-11-12-0.4.0
- Release manifest SHA-256
- 0f4a8d8c48aee2a7573ae0fa94ecbeab70c1adbe449bbc95c424bc7d3e97b9d4
- Registry capture
- 2026-11-12
- Results copy, AACT
- 2026-03-23
- NIH clinical studies file
- 2026-11-13
Source ClinicalTrials.gov
Sources 3
- ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
- ClinicalTrials.govNone stated
- NIH RePORTER's clinical studies and project filesPublic domain
Each source's terms
- ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
- ClinicalTrials.govnone stated
- NIH RePORTER's clinical studies and project filesPublic domain (NIH RePORTER)
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.
For software
Read this trial from software.
The record and each of its lists are JSON, twenty rows a page. No key.
GET https://conductscience.org/api/trials/v1/NCT05146089
GET https://conductscience.org/api/trials/v1/NCT05146089/registered