The Dortmund Vital Study: Impact of Biological and Lifestyle Factors on Cognitive Performace and Work Ability
NCT05155397, Active not recruiting, Technical University of Dortmund
Trial 8
As registered on ClinicalTrials.gov, in the graph's capture of the registry.
| Field | Value | Source |
|---|---|---|
| Title | The Dortmund Vital Study: Impact of Biological and Lifestyle Factors on Cognitive Performace and Work Ability | ClinicalTrials.gov |
| NCT number | NCT05155397 | ClinicalTrials.gov |
| Status | Active not recruiting | ClinicalTrials.gov |
| Enrollment | 627 participants, actual | ClinicalTrials.gov |
| Lead sponsor | Technical University of Dortmund | ClinicalTrials.gov |
| Conditions | Age-related Cognitive Decline | ClinicalTrials.gov |
| First posted | 2021-12-13 | ClinicalTrials.gov |
| Last updated | 2026-10-02 | ClinicalTrials.gov |
Registered outcomes 52
Each outcome the trial registered, primary first, in ClinicalTrials.gov's words.
| List | Outcome | Time frame | Description | Source |
|---|---|---|---|---|
| Primary | Change in performance on global cognitive composite score assessed by neuropsychological tests | Baseline and 5, 10, 15 years | Change in performance on global cognitive composite score based on measures from neuropsychological tests: Digit-Span forward and backward, semantic memory in written and spoken versions (Word-Fluency), selective attention and attentional endurance (D2-R), crystallized intelligence (Multiple Choice Vocabulary Test), general cognitive status (Mini-Mental-State-Examination; MMSE), different aspects of verbal memory like learning performance and retrieval (Verbal Learning and Memory Tests; VLMT), psychomotor performance and speed of processing (Digit-Symbol-Test), interference control and inhibition (Stroop Test), task switching (Trail-Making-Test; TMT-A and TMT-B), two subtests from the performance testing system measuring logical reasoning and spatial rotation, and fluid intelligence assessed by Raven's Progressive Matrices. | ClinicalTrials.gov |
| Primary | Change in attentional performance and perceptual control as assessed by a computerized Bar Task | Baseline and 5, 10, 15 years | Changes in behavioral (speed and accuracy) and electroencephalogram (EEG) data in attentional performance and perceptual control assessed by the Bar Task. | ClinicalTrials.gov |
| Primary | Change in vigilance control as assessed by a computerized Psychomotor Vigilance Test | Baseline and 5, 10, 15 years | Changes in behavioral (speed and accuracy) and electroencephalogram (EEG) data in a Psychomotor Vigilance Test. | ClinicalTrials.gov |
| Primary | Change in stimulus-response compatibility and conflict processing assessed by the computerized Simon Task | Baseline and 5, 10, 15 years | Changes in behavioral (speed and accuracy) and electroencephalogram (EEG) data in the Simon task. | ClinicalTrials.gov |
| Primary | Change in updating and strategy learning assessed by the computerized AX-CPT Task | Baseline and 5, 10, 15 years | Changes in behavioral (speed and accuracy) and electroencephalogram (EEG) data in the AX-CPT task. | ClinicalTrials.gov |
| Primary | Change in speech understanding and auditory distractibility assessed by computerized Speech-In-Noise perception task | Baseline and 5, 10, 15 years | Changes in behavioral (speed and accuracy) and electroencephalogram (EEG) data in the Speech-in-noise perception task. | ClinicalTrials.gov |
| Primary | Change in working memory assessed by the computerized N-back Task | Baseline and 5, 10, 15 years | Changes in behavioral (speed and accuracy) and electroencephalogram (EEG) data in the N-back task. | ClinicalTrials.gov |
| Primary | Change in cue and memory-based task switching assessed by the computerized Task Switching Paradigm | Baseline and 5, 10, 15 years | Changes in behavioral (speed and accuracy) and electroencephalogram (EEG) data in the cue- and memory based task switching. | ClinicalTrials.gov |
| Primary | Change in auditive attention and distractibility assessed by the computerized Auditory Distraction Task | Baseline and 5, 10, 15 years | Changes in behavioral (speed and accuracy) and electroencephalogram (EEG) data in the Auditory Distraction Task. | ClinicalTrials.gov |
| Primary | Change in susceptibility to interference and the capacity to inhibit irrelevant stimuli assessed by the computerized Stroop Task | Baseline and 5, 10, 15 years | Changes in behavioral (speed and accuracy) and electroencephalogram (EEG) data in the Stroop Task. | ClinicalTrials.gov |
| Primary | Change in inhibitory control of prepotent responses assessed by the computerized Go/NoGo Task | Baseline and 5, 10, 15 years | Changes in behavioral (speed and accuracy) and electroencephalogram (EEG) data in the Go/NoGo Task. | ClinicalTrials.gov |
| Primary | Change in spatial selective attention assessed by the computerized Visual Search Task | Baseline and 5, 10, 15 years | Changes in behavioral (speed and accuracy) and electroencephalogram (EEG) data in the Visual Search Task. | ClinicalTrials.gov |
| Primary | Change in Work Ability Index | Baseline and 5, 10, 15 years | Change in work ability assessed by Work Ability Index (WAI). WAI assess physical and psychological risks to avoid work-related disabilities and early retirement. The index is determined by the employees' answers related to work demands, individual health status and physical and psychological capacities. The total score of WAI is calculated by summing up scores of seven dimensions. The work ability ranged between 7 (insufficient) and 49 points (best work ability). | ClinicalTrials.gov |
| Secondary | Change in resting state EEG activity | baseline and 5, 10, 15 years | Change in resting state EEG activity measured for 2 minutes with eyes open, and 2 minutes with eyes closed. | ClinicalTrials.gov |
| Secondary | Change in brain function MRI | 5, 10, 15 years | Changes in functional magnetic resonance imaging assessed by resting state MRI. | ClinicalTrials.gov |
| Secondary | Change in brain structure MRI | 5, 10, 15 years | Changes in structural resonance imaging assessed by multi-shell diffusion-weighted imaging (DWI). | ClinicalTrials.gov |
| Secondary | Change in Depressive Symptoms | Baseline and 5, 10, 15 years | Change in total score using the Becks Depression Inventory (BDI). | ClinicalTrials.gov |
| Secondary | Change in Burnout Symptoms | Baseline and 5, 10, 15 years | Change in total score using the Maslach Burnout Inventory (MBI-D) with 6-point Likert-type scale ranging from 1 (never) to 6 (always), total scores: 14 - 84. Higher scores indicate more severe symptoms. | ClinicalTrials.gov |
| Secondary | Change in Burnout Symptoms | Baseline and 5, 10, 15 years | Change in total score using the Oldenburg Burnout Inventory (OLBI). 4-point Likert-type scale ranging from 1 (strongly agree) to 4 (strongly disagree), total scores: 8 - 32. Higher scores indicate more severe symptoms. | ClinicalTrials.gov |
| Secondary | Change in Psychosocial Stress Symptoms | Baseline and 5, 10, 15 years | Change in total score using the Psychosocial Stress Questionnaire (PSQ-20). | ClinicalTrials.gov |
Outcomes 0
Each outcome the trial posted results for, in ClinicalTrials.gov's words.
| Type | Outcome | Time frame | Population | Units | Measured as | Source |
|---|
Results by group 0
Each measurement the trial posted, group by group, in the words and numbers it posted.
| Outcome | Group | Category | Value | Spread | Units | Source |
|---|
Participant flow 0
How many started, completed or left each group, period by period.
| Period | Milestone | Group | Participants | Units counted | Source |
|---|
Adverse events 0
Each adverse event the trial posted, group by group: the participants affected out of those at risk.
| Type | Event | Organ system | Group | Affected | At risk | Events | Source |
|---|
Adverse event totals 0
The totals the trial posted for each group.
| Total | Group | Affected | At risk | Source |
|---|
Papers 33
The papers the trial lists on ClinicalTrials.gov.
| PMID | Listed as | Source |
|---|---|---|
| 30534095 | RESULT | PubMed |
| 32923622 | RESULT | PubMed |
| 34216693 | RESULT | PubMed |
| 34676455 | RESULT | PubMed |
| 34682500 | RESULT | PubMed |
| 34859527 | RESULT | PubMed |
| 35285810 | RESULT | PubMed |
| 35675345 | RESULT | PubMed |
| 36358277 | RESULT | PubMed |
| 36525080 | RESULT | PubMed |
| 36682499 | RESULT | PubMed |
| 36881943 | RESULT | PubMed |
| 37099727 | RESULT | PubMed |
| 37204831 | RESULT | PubMed |
| 37397318 | RESULT | PubMed |
| 37410275 | RESULT | PubMed |
| 37450085 | RESULT | PubMed |
| 37685992 | RESULT | PubMed |
| 37861818 | RESULT | PubMed |
| 38398703 | RESULT | PubMed |
Trial comparisons 0
Comparisons of the trial's two groups, calculated by ConductScience from the counts it posted.
| Comparison | Source |
|---|
Tests 14
The ConductCognition tests this trial's registered outcomes name, as ScienceGraph matched them in trial-tests-2026-11-12-0.2.1.
| Test | Named as | Source |
|---|---|---|
| 1-Back Task | Primary outcome | ConductCognition |
| 2-Back Task | Primary outcome | ConductCognition |
| AX Continuous Performance Test | Primary outcome | ConductCognition |
| Digit Span Test | Primary outcome | ConductCognition |
| Go/No-Go Task | Primary outcome | ConductCognition |
| Matrix Reasoning | Primary outcome | ConductCognition |
| Psychomotor Vigilance Task | Primary outcome | ConductCognition |
| Simon Task | Primary outcome | ConductCognition |
| Stroop Color-Word Test | Primary outcome | ConductCognition |
| Symbol Coding | Primary outcome | ConductCognition |
| Task Switching Test | Primary outcome | ConductCognition |
| Trail Making Test A | Primary outcome | ConductCognition |
| Trail Making Test B | Primary outcome | ConductCognition |
| Visual Search Test | Primary outcome | ConductCognition |
Source 4
| Field | Value | Source |
|---|---|---|
| Release | trials-2026-11-12-0.3.0 | ClinicalTrials.gov |
| Release manifest SHA-256 | 4a570df2e7274cee2d4fa2959402fab41880e2cd412e4b590390035fbea69391 | ClinicalTrials.gov |
| Registry capture | 2026-11-12 | ClinicalTrials.gov |
| Results copy, AACT | 2026-03-23 | ClinicalTrials.gov |
Release trials-2026-11-12-0.3.0
ClinicalTrials.gov's posted results, through CTTI's AACT: ClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299 ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.
ClinicalTrials.gov: none stated ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.