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Trial · NCT05174416

Results by group18

Each measurement the trial posted, group by group, in the words and numbers it posted.

OutcomeGroupCategoryValueSpreadUnits
Change From Baseline to Week 30 in Valsalva Left Ventricular Outflow Tract (LVOT) Peak GradientMavacamten-51.05Standard Deviation 6.150mmHg
Change From Baseline to Week 30 in Valsalva Left Ventricular Outflow Tract (LVOT) Peak GradientPlacebo19.23Standard Deviation 8.535mmHg
Change From Baseline to Week 30 in Resting LVOT Peak GradientMavacamten-49.04Standard Deviation 4.637mmHg
Change From Baseline to Week 30 in Resting LVOT Peak GradientPlacebo5.95Standard Deviation 6.311mmHg
Proportion of Participants Achieving a Valsalva LVOT Peak Gradient < 30 mmHg at Week 30Mavacamten26Participants
Proportion of Participants Achieving a Valsalva LVOT Peak Gradient < 30 mmHg at Week 30Placebo1Participants
Proportion of Participants Achieving a Valsalva LVOT Peak Gradient < 50 mmHg at Week 30.Mavacamten32Participants
Proportion of Participants Achieving a Valsalva LVOT Peak Gradient < 50 mmHg at Week 30.Placebo2Participants
Proportion of Participants With at Least 1 Class Improvement in New York Heart Association (NYHA) Functional Classification From Baseline to Week 30Mavacamten32Participants
Proportion of Participants With at Least 1 Class Improvement in New York Heart Association (NYHA) Functional Classification From Baseline to Week 30Placebo4Participants
Change From Baseline to Week 30 in Kansas City Cardiomyopathy Questionnaire (KCCQ) Clinical Summary Score (CSS)Mavacamten4.99Standard Deviation 2.063score on a scale
Change From Baseline to Week 30 in Kansas City Cardiomyopathy Questionnaire (KCCQ) Clinical Summary Score (CSS)Placebo-5.25Standard Deviation 2.750score on a scale
Change From Baseline to Week 30 in N-terminal Pro-B-type Natriuretic Peptide (NT-proBNP)Mavacamten0.182Standard Deviation 0.1743ng/L
Change From Baseline to Week 30 in N-terminal Pro-B-type Natriuretic Peptide (NT-proBNP)Placebo0.932Standard Deviation 0.5133ng/L
Change From Baseline to Week 30 in Cardiac TroponinMavacamten0.419Standard Deviation 0.1983ng/L
Change From Baseline to Week 30 in Cardiac TroponinPlacebo1.236Standard Deviation 0.6528ng/L
Change From Baseline to Week 30 in Left Ventricular (LV) Mass IndexMavacamten-26.365Standard Deviation 21.0565g/m^2
Change From Baseline to Week 30 in Left Ventricular (LV) Mass IndexPlacebo4.434Standard Deviation 14.4226g/m^2

Source ClinicalTrials.govtrials-2026-11-12-0.4.0

Sources 3

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ClinicalTrials.govNone stated
  • NIH RePORTER's clinical studies and project filesPublic domain
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ClinicalTrials.govnone stated
  • NIH RePORTER's clinical studies and project filesPublic domain (NIH RePORTER)

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

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