Trial · NCT05212597
Open Label RCT for Chronic Severe AR : Entresto vs. CCB/ARB
NCT05212597, Phase 2, Unknown, Samsung Medical Center
3 sourcestrials-2026-11-12-0.5.0
Cite this record
ConductScience Library. Open Label RCT for Chronic Severe AR : Entresto vs. CCB/ARB. Trials, record NCT05212597. Release trials-2026-11-12-0.5.0, 12 Nov 2026. https://conductscience.org/library/trials/NCT05212597
On this page
Trial
As registered on ClinicalTrials.gov, in the graph's capture of the registry.
- Title
- Open Label RCT for Chronic Severe AR : Entresto vs. CCB/ARB
- NCT number
- NCT05212597
- Status
- Unknown
- Phases
- Phase 2
- Enrollment
- 100 participants, estimated
- Lead sponsor
- Samsung Medical Center
- Conditions
- Aortic Valve Insufficiency
- Interventions
- Sacubitril-valsartan, Amlodipine-losartan
- First posted
- 2022-01-28
- Last updated
- 2022-01-28
Source ClinicalTrials.gov
Registered outcomes7
Each outcome the trial registered, primary first, in ClinicalTrials.gov's words.
| List | Outcome | Time frame | Description |
|---|---|---|---|
| Primary | Change of left ventricular end-diastolic volume index from baseline to 12 months follow-up | Baseline and month 12 | Change = \[LVEDV on CMR at 12 months\]-\[LVEDV on CMR at baseline\] |
| Secondary | Change of regurgitant volume of aortic valve regurgitation from baseline to 12 months follow-up. | Baseline and month 12 | Change = \[regurgitant volume at 12 months\]-\[regurgitant volume at baseline\] |
| Secondary | Change of EROA of aortic valve regurgitation from baseline to 12 months follow-up. | Baseline and month 12 | Measurement of regurgitant volume of AR is derived from Doppler imaging on echocardiography. Change = \[regurgitant volume at 12 months\]-\[regurgitant volume at baseline\] |
| Secondary | Change of LV end-systolic volume from baseline to 12 months follow-up. | Baseline and month 12 | Change = \[LVEDV at 12 months\]-\[LVEDV at baseline\] |
| Secondary | Holodiastolic flow reversal in the proximal abdominal aorta and descending thoracic aorta from baseline to 12 months follow-up | Baseline and month 12 | presence or absence of holodiastolic flow reversal in the proximal abdominal and descending thoracic aorta on echocardiography |
| Secondary | Change of NT-proBNP level from baseline to 12 months follow-up. | Baseline and month 12 | Change =\[NT-proBNP at 12 months\]-\[NTproBNP at baseline\] |
| Secondary | Aortic valve replacement or repair operation | During 12 months after enrollment | Any surgical event for correction of AR |
Source ClinicalTrials.gov
Outcomes0
Each outcome the trial posted results for, in ClinicalTrials.gov's words.
None in this release.
Results by group0
Each measurement the trial posted, group by group, in the words and numbers it posted.
None in this release.
Participant flow0
How many started, completed or left each group, period by period.
None in this release.
Adverse events0
Each adverse event the trial posted, group by group: the participants affected out of those at risk.
None in this release.
Adverse event totals0
The totals the trial posted for each group.
None in this release.
Papers0
The papers the trial lists on ClinicalTrials.gov.
None in this release.
Grants0
The grants NIH RePORTER links to the trial, newest funded first: NIH's, and some of AHRQ's, CDC's, FDA's and VA's. Each shows its title, principal investigators, organization and funder in its newest year.
None in this release.
Trial comparisons0
Comparisons of the trial's two groups, calculated by ConductScience from the counts it posted.
None in this release.
Tests0
The ConductCognition tests this trial's registered outcomes name, as ScienceGraph matched them in trial-tests-2026-11-12-0.2.1.
None in this release.
Data dates
The day each source was copied for this release.
Sources 3
- ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
- ClinicalTrials.govNo license stated
- NIH RePORTER's clinical studies and project filesPublic domain
Each source's terms
- ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
- ClinicalTrials.govnone stated
- NIH RePORTER's clinical studies and project filesPublic domain (NIH RePORTER)
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.
For software
Read this trial from software.
The record and each of its lists are JSON, twenty rows a page. No key.
GET https://conductscience.org/api/trials/v1/NCT05212597
GET https://conductscience.org/api/trials/v1/NCT05212597/registered