Trial · NCT05216757
Efficacy and Safety of Iguratimod in Patients With Hand Osteoarthritis (ESIGO)
NCT05216757, Phase 2, Phase 3, Unknown, Peking University People's Hospital
3 sourcestrials-2026-11-12-0.5.0
Cite this record
ConductScience Library. Efficacy and Safety of Iguratimod in Patients With Hand Osteoarthritis (ESIGO). Trials, record NCT05216757. Release trials-2026-11-12-0.5.0, 12 Nov 2026. https://conductscience.org/library/trials/NCT05216757
On this page
Trial
As registered on ClinicalTrials.gov, in the graph's capture of the registry.
- Title
- Efficacy and Safety of Iguratimod in Patients With Hand Osteoarthritis (ESIGO)
- NCT number
- NCT05216757
- Status
- Unknown
- Phases
- Phase 2, Phase 3
- Enrollment
- 150 participants, estimated
- Lead sponsor
- Peking University People's Hospital
- Conditions
- Hand Osteoarthritis, Inflammatory Arthritis
- Interventions
- Iguratimod, placebo
- First posted
- 2022-01-31
- Last updated
- 2022-02-08
Source ClinicalTrials.gov
Registered outcomes16
Each outcome the trial registered, primary first, in ClinicalTrials.gov's words.
| List | Outcome | Time frame | Description |
|---|---|---|---|
| Primary | Change from baseline in patient's assessment of arthritis pain on a visual analogue scale | 12 weeks | Change from baseline in self-reported finger joint pain previous 48 hours on a 0-100 mm scale at 12 weeks of treatment; higher value indicate worse outcome. |
| Secondary | Change from baseline in patient's assessment of arthritis pain on a visual analogue scale prior to each visit | 4 weeks, 8 weeks, 12 weeks | Differences in self-reported finger joint pain previous 48 hours on a 0-100 mm scale at 4 weeks, 8 weeks, and 12 weeks; higher value indicate worse outcome. |
| Secondary | Change from baseline in Australian Canadian Hand Osteoarthritis Index (AUSCAN) scores at each visit. | 4 weeks, 8 weeks, 12 weeks | The AUSCAN Index is a self-administered questionnaire consisting of a 15-item scale which measures pain (5 items), stiffness (1 item) and degree of disability/physical function (9 items) during the preceding 48 hours; higher value indicate worse outcome. |
| Secondary | Change from baseline in Functional Index for Hand Osteoarthritis (FIHOA) | 12 weeks | The Functional Index for Hand Osteoarthritis (FIHOA) is a leading assessment tool for hand OA-related functional impairment; higher value indicate worse outcome. |
| Secondary | Change from baseline in Health Assessment Questionnaire Disability Index (HAQ) | 12 weeks | Change from baseline in Health Assessment Questionnaire Disability Index (HAQ) at week 12; higher value indicate worse outcome. |
| Secondary | Change from baseline in the Scores of SF-36 questionnaire | 12 weeks | Change from baseline in SF-36, including physical and mental component sores (PCS and MCS) at week 12; higher value indicate worse outcome. |
| Secondary | Change from baseline in Michigan Hand Outcomes Questionnaire (MHOQ) | 12 weeks | Michigan Hand Outcomes Questionnaire (MHOQ) pain and physical function subscales; function subscale range 10-50, higher value indicate worse outcome; task subscale range 17-85, higher value indicate worse outcome; work subscale range 5-25, higher value indicate worse outcome; pain subscale range 10-48, higher value indicate better outcome. |
| Secondary | Change from baseline in Ultrasound record | 12 weeks | Ultrasound record: number of finger joints with synovial thickening and power Doppler signals. |
| Secondary | Change from baseline in OMERACT hand OA magnetic resonance imaging score | 12 weeks | OMERACT hand OA magnetic resonance imaging score includes synovitis (0-3), erosive damage(0-3), cyst (0-3), osteophyte (0-3), cartilage space loss(0-3), malalignment (0-3), and bone marrow lesions (0-3); higher value indicate worse outcome |
| Other | Change from baseline in Erythrocyte Sedimentation Rate (ESR) | 12 weeks | Erythrocyte Sedimentation Rate (ESR); higher value indicate worse outcome. |
1 to 10 of 16Source ClinicalTrials.gov
See all 16 registered outcomesOutcomes0
Each outcome the trial posted results for, in ClinicalTrials.gov's words.
None in this release.
Results by group0
Each measurement the trial posted, group by group, in the words and numbers it posted.
None in this release.
Participant flow0
How many started, completed or left each group, period by period.
None in this release.
Adverse events0
Each adverse event the trial posted, group by group: the participants affected out of those at risk.
None in this release.
Adverse event totals0
The totals the trial posted for each group.
None in this release.
Papers0
The papers the trial lists on ClinicalTrials.gov.
None in this release.
Grants0
The grants NIH RePORTER links to the trial, newest funded first: NIH's, and some of AHRQ's, CDC's, FDA's and VA's. Each shows its title, principal investigators, organization and funder in its newest year.
None in this release.
Trial comparisons0
Comparisons of the trial's two groups, calculated by ConductScience from the counts it posted.
None in this release.
Tests0
The ConductCognition tests this trial's registered outcomes name, as ScienceGraph matched them in trial-tests-2026-11-12-0.2.1.
None in this release.
Data dates
The day each source was copied for this release.
Sources 3
- ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
- ClinicalTrials.govNo license stated
- NIH RePORTER's clinical studies and project filesPublic domain
Each source's terms
- ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
- ClinicalTrials.govnone stated
- NIH RePORTER's clinical studies and project filesPublic domain (NIH RePORTER)
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.
For software
Read this trial from software.
The record and each of its lists are JSON, twenty rows a page. No key.
GET https://conductscience.org/api/trials/v1/NCT05216757
GET https://conductscience.org/api/trials/v1/NCT05216757/registered