Trial · NCT05225402
Hemodynamic Measurements of Macrocirculatory and Perfusion Parameters in ICU
NCT05225402, Recruiting, Copenhagen University Hospital, Hvidovre
3 sourcestrials-2026-11-12-0.5.0
Cite this record
ConductScience Library. Hemodynamic Measurements of Macrocirculatory and Perfusion Parameters in ICU. Trials, record NCT05225402. Release trials-2026-11-12-0.5.0, 12 Nov 2026. https://conductscience.org/library/trials/NCT05225402
On this page
Trial
As registered on ClinicalTrials.gov, in the graph's capture of the registry.
- Title
- Hemodynamic Measurements of Macrocirculatory and Perfusion Parameters in ICU
- NCT number
- NCT05225402
- Status
- Recruiting
- Enrollment
- 45 participants, estimated
- Lead sponsor
- Copenhagen University Hospital, Hvidovre
- Conditions
- Septic Shock, Hemodynamic Instability, Vasoconstriction
- Interventions
- Hemodynamic measurements during reduction in Norepinephrine and fluid boli.
- First posted
- 2022-02-04
- Last updated
- 2025-03-07
Source ClinicalTrials.gov
Registered outcomes4
Each outcome the trial registered, primary first, in ClinicalTrials.gov's words.
| List | Outcome | Time frame | Description |
|---|---|---|---|
| Primary | Preload responsiveness defined as stroke volume increase > 10%, measured by continuous arterial waveform analysis. | Through study completion, an average of 1 year | The number of patients who were preload responsive after down-titration of NE. |
| Secondary | Cardiac output response measured by lithium indicator dilution and Doppler ultrasound. | Through study completion, an average of 1 year | The effect on cardiac output after fluid bolus and subsequent up-titration of NE to the pre-intervention blood pressure target. |
| Secondary | Microcirculation/perfusion measures during intervention. | Through study completion, an average of 1 year | The effect of the intervention on measures of tissue perfusion. Different topical sites (Brain, Muscle, Finger, Urethra, Sublingual) by minimal- or noninvasive methods. |
| Secondary | CO measurement method | Through study completion, an average of 1 year | Assess the correlation between indirect measurements of CO and lithium dilution measured CO during NE titration. |
Source ClinicalTrials.gov
Outcomes0
Each outcome the trial posted results for, in ClinicalTrials.gov's words.
None in this release.
Results by group0
Each measurement the trial posted, group by group, in the words and numbers it posted.
None in this release.
Participant flow0
How many started, completed or left each group, period by period.
None in this release.
Adverse events0
Each adverse event the trial posted, group by group: the participants affected out of those at risk.
None in this release.
Adverse event totals0
The totals the trial posted for each group.
None in this release.
Papers0
The papers the trial lists on ClinicalTrials.gov.
None in this release.
Grants0
The grants NIH RePORTER links to the trial, newest funded first: NIH's, and some of AHRQ's, CDC's, FDA's and VA's. Each shows its title, principal investigators, organization and funder in its newest year.
None in this release.
Trial comparisons0
Comparisons of the trial's two groups, calculated by ConductScience from the counts it posted.
None in this release.
Tests0
The ConductCognition tests this trial's registered outcomes name, as ScienceGraph matched them in trial-tests-2026-11-12-0.2.1.
None in this release.
Data dates
The day each source was copied for this release.
Sources 3
- ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
- ClinicalTrials.govNo license stated
- NIH RePORTER's clinical studies and project filesPublic domain
Each source's terms
- ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
- ClinicalTrials.govnone stated
- NIH RePORTER's clinical studies and project filesPublic domain (NIH RePORTER)
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.
For software
Read this trial from software.
The record and each of its lists are JSON, twenty rows a page. No key.
GET https://conductscience.org/api/trials/v1/NCT05225402
GET https://conductscience.org/api/trials/v1/NCT05225402/registered