Exercise in Older Adults at Risk for Type 2 Diabetes
NCT05229705, Not applicable, Completed, Western University, Canada
Trial 10
As registered on ClinicalTrials.gov, in the graph's capture of the registry.
| Field | Value | Source |
|---|---|---|
| Title | Exercise in Older Adults at Risk for Type 2 Diabetes | ClinicalTrials.gov |
| NCT number | NCT05229705 | ClinicalTrials.gov |
| Status | Completed | ClinicalTrials.gov |
| Phases | Not applicable | ClinicalTrials.gov |
| Enrollment | 60 participants, actual | ClinicalTrials.gov |
| Lead sponsor | Western University, Canada | ClinicalTrials.gov |
| Conditions | Cognitive Change | ClinicalTrials.gov |
| Interventions | Resistance exercise | ClinicalTrials.gov |
| First posted | 2022-02-08 | ClinicalTrials.gov |
| Last updated | 2024-10-15 | ClinicalTrials.gov |
Registered outcomes 21
Each outcome the trial registered, primary first, in ClinicalTrials.gov's words.
| List | Outcome | Time frame | Description | Source |
|---|---|---|---|---|
| Primary | Trail Making Test | 5 minutes | Used to assess executive function in the areas of visual attention (Part A) and set-shifting (the ability to shift attention between one task and another; Part B). The time to complete this test is recorded in seconds. | ClinicalTrials.gov |
| Secondary | Paired Associative Learning (PAL) Touchscreen Task | 20 minutes | Used to test learning and remembering of three objects that are associated with a correct spatial location on the screen. | ClinicalTrials.gov |
| Secondary | Trail Unique-Non-Matching-Location (TUNL) Task | 20 minutes | This is a working spatial memory task that involves selecting a different stimulus (non-matching) to the stimulus presented on the screen after a delay period. The stimuli are presented in locations far apart or close together to challenge spatial memory. | ClinicalTrials.gov |
| Secondary | Progressive Ratio (PR) Touchscreen Task | 20 minutes | This task tests motivation and attention. The task involves touching a square stimulus at the center of the screen repeatedly for points in a single trial. The number of touches required for points increases on a ramp scale, which begins at one touch for points and then is increased by four on each subsequent trial for points. If the participant stops responding for 5 minutes, the task stops, and the point of break (stopping) is recorded. | ClinicalTrials.gov |
| Secondary | Stroop Test | 5-10 minutes | Used to assess executive function in the areas of selective attention, processing speed, and cognitive flexibility. The time to complete this test is recorded in seconds. | ClinicalTrials.gov |
| Secondary | Digit Span Test | 5-10 minutes | Used to assess working memory. Participants are required to memorize and recall a series of number lists both forward and backward. | ClinicalTrials.gov |
| Secondary | Alzheimer's Disease Assessment Scale Cognitive Subscale 11 | 15 minutes | Test with 11 tasks measuring various cognitive functions (memory, language, praxis, attention). Used widely in clinical trials to assess cognitive dysfunction and Alzheimer's Disease. | ClinicalTrials.gov |
| Secondary | Glycated hemoglobin A1c (HbA1C) | 5-10 minutes | We will collect blood samples to test glycated hemoglobin levels to determine diabetes status (pre-diabetes, diabetes). Blood will be drawn from a cubital vein into a 7.5 ml tube. Blood draws will be done by RN Arlene Fleischhauer in Co-I Kevin Shoemaker's lab or by trained support staff, Olivia Ghosh-Swaby. | ClinicalTrials.gov |
| Secondary | Fasting plasma glucose | 5-10 minutes | We will collected via a glucometer finger prick | ClinicalTrials.gov |
| Secondary | Height | 5 minutes | Measured in m; used to calculate body mass index (kg/m\^2) | ClinicalTrials.gov |
| Secondary | Weight | 5 minutes | Measured in kg; used to calculate body mass index (kg/m\^2) | ClinicalTrials.gov |
| Secondary | Triglyceride levels | 30 minutes | Will be assessed via serum samples measured by ELISA. | ClinicalTrials.gov |
| Secondary | Inflammatory markers | 30 minutes | Will be assessed via serum samples measured by ELISA. | ClinicalTrials.gov |
| Secondary | Brain-derived neurotrophic factor levels | 1 hour | Will be assessed via serum samples measured by ELISA. | ClinicalTrials.gov |
| Secondary | Insulin-like growth factor levels | 1 hour | Will be assessed via serum samples measured by ELISA. | ClinicalTrials.gov |
| Secondary | One repetition maximum | 10-15 minutes | One-repetition maximum is a physical measure of an individual's maximum muscle strength during a single repetition and is used to determine the desired load for resistance training. | ClinicalTrials.gov |
| Secondary | Six-minute walk test | 6 minutes | Used to assess aerobic fitness. Participants walk at their usual speed for a total of 6 minutes in the hallway outside of our lab. The total distance walked in meters is recorded. | ClinicalTrials.gov |
| Secondary | Short Physical Performance Battery (SPPB) - Task 1 | 5 minutes | Used to assess gait speed, balance, and lower extremity physical function using tasks that mimic daily activities; the Standing Balance Task requires participants to stand unassisted (side-by-side standing, semi-tandem standing, and tandem standing) for a period of 10 seconds each; scored in conjunction with SPPB Tasks 2 \& 3 to produce one final SPPB score | ClinicalTrials.gov |
| Secondary | Short Physical Performance Battery (SPPB) - Task 2 | 5 minutes | Used to assess gait speed, balance, and lower extremity physical function using tasks that mimic daily activities; the Walking Speed Task requires participants to walk 4 metres at their usual pace; measured in seconds; scored in conjunction with SPPB Tasks 1 \& 3 to produce one final SPPB score | ClinicalTrials.gov |
| Secondary | Short Physical Performance Battery (SPPB) - Task 3 | 5 minutes | Used to assess gait speed, balance, and lower extremity physical function using tasks that mimic daily activities; the Chair Stand Test requires participants to stand up from a chair 5 times consecutively (without the use of their arms if possible); measured in seconds; scored in conjunction with SPPB Tasks 1 \& 2 to produce one final SPPB score | ClinicalTrials.gov |
Outcomes 0
Each outcome the trial posted results for, in ClinicalTrials.gov's words.
| Type | Outcome | Time frame | Population | Units | Measured as | Source |
|---|
Results by group 0
Each measurement the trial posted, group by group, in the words and numbers it posted.
| Outcome | Group | Category | Value | Spread | Units | Source |
|---|
Participant flow 0
How many started, completed or left each group, period by period.
| Period | Milestone | Group | Participants | Units counted | Source |
|---|
Adverse events 0
Each adverse event the trial posted, group by group: the participants affected out of those at risk.
| Type | Event | Organ system | Group | Affected | At risk | Events | Source |
|---|
Adverse event totals 0
The totals the trial posted for each group.
| Total | Group | Affected | At risk | Source |
|---|
Papers 4
The papers the trial lists on ClinicalTrials.gov.
Grants 0
The grants NIH RePORTER links to the trial, newest funded first: NIH's, and some of AHRQ's, CDC's, FDA's and VA's. Each shows its title, principal investigators, organization and funder in its newest year.
| Project | Title | Principal investigators | Organization | Funder | Fiscal years | Source |
|---|
Trial comparisons 0
Comparisons of the trial's two groups, calculated by ConductScience from the counts it posted.
| Comparison | Source |
|---|
Tests 4
The ConductCognition tests this trial's registered outcomes name, as ScienceGraph matched them in trial-tests-2026-11-12-0.2.1.
| Test | Named as | Source |
|---|---|---|
| Trail Making Test A | Primary outcome | ConductCognition |
| Trail Making Test B | Primary outcome | ConductCognition |
| Digit Span Test | Secondary outcome | ConductCognition |
| Stroop Color-Word Test | Secondary outcome | ConductCognition |
Source 5
| Field | Value | Source |
|---|---|---|
| Release | trials-2026-11-12-0.4.0 | ClinicalTrials.gov |
| Release manifest SHA-256 | 0f4a8d8c48aee2a7573ae0fa94ecbeab70c1adbe449bbc95c424bc7d3e97b9d4 | ClinicalTrials.gov |
| Registry capture | 2026-11-12 | ClinicalTrials.gov |
| Results copy, AACT | 2026-03-23 | ClinicalTrials.gov |
| NIH clinical studies file | 2026-11-13 | ClinicalTrials.gov |
Release trials-2026-11-12-0.4.0
ClinicalTrials.gov's posted results, through CTTI's AACT: ClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299 ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.
ClinicalTrials.gov: none stated ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.
NIH RePORTER's clinical studies and project files: Public domain (NIH RePORTER)