Trial · NCT05239195
DirEct Versus VIdeo LaryngosCopE Trial
NCT05239195, Not applicable, Completed, Vanderbilt University Medical Center; results first posted 2024-08-19
3 sourcestrials-2026-11-12-0.5.0
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ConductScience Library. DirEct Versus VIdeo LaryngosCopE Trial. Trials, record NCT05239195. Release trials-2026-11-12-0.5.0, 12 Nov 2026. https://conductscience.org/library/trials/NCT05239195
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Trial
As registered on ClinicalTrials.gov, in the graph's capture of the registry.
- Title
- DirEct Versus VIdeo LaryngosCopE Trial
- NCT number
- NCT05239195
- Status
- Completed
- Phases
- Not applicable
- Enrollment
- 1,420 participants, actual
- Lead sponsor
- Vanderbilt University Medical Center
- Conditions
- Acute Respiratory Failure
- Interventions
- Video Laryngoscope, Direct Laryngoscope
- First posted
- 2022-02-14
- Last updated
- 2024-08-19
- Results first posted
- 2024-08-19
Source ClinicalTrials.gov
Registered outcomes13
Each outcome the trial registered, primary first, in ClinicalTrials.gov's words.
| List | Outcome | Time frame | Description |
|---|---|---|---|
| Primary | Number of Intubations With Successful Intubation on the First Attempt | Duration of procedure (minutes) | The primary outcome is defined as placement of an endotracheal tube in the trachea with a single insertion of a laryngoscope blade into the mouth and EITHER a single insertion of an endotracheal tube into the mouth OR a single insertion of a bougie into the mouth followed by a single insertion of an endotracheal tube over the bougie into the mouth. |
| Secondary | Number of Participants With Severe Complications of Tracheal Intubation | from induction to 2 minutes following tracheal intubation | The secondary outcome is defined as the number of patients who experienced one or more of the following occurring between induction and 2 minutes after successful intubation: * Severe hypoxemia (lowest oxygen saturation measured by pulse oximetry \< 80%); * Severe hypotension (systolic blood pressure \< 65 mm Hg or new or increased vasopressor administration); * Cardiac arrest not resulting in death within 1 hour of intubation; or * Cardiac arrest resulting in death within 1 hour of induction |
| Other | Duration of Laryngoscopy and Tracheal Intubation | Duration of procedure (minutes) | The interval (in seconds) between the first insertion of a laryngoscope blade into the mouth and the final placement of an endotracheal tube or tracheostomy tube in the trachea. |
| Other | Number of Laryngoscopy Attempts | Duration of procedure (minutes) | |
| Other | Number of Attempts to Cannulate the Trachea With a Bougie or an Endotracheal Tube | Duration of procedure (minutes) | |
| Other | Successful Intubation on the First Attempt Without a Severe Complication | from induction to 2 minutes following tracheal intubation | This outcome reports the number of participants that experienced successful intubation on the first attempt without experiencing complications, a composite of two independent outcomes: successful intubation on the first attempt (the primary outcome of the trial) and severe complication (the secondary outcome of the trial). |
| Other | Reason for Failure to Intubate on the First Attempt | Duration of procedure (minutes) | Providers could give more than one reason for failure to intubate on the first attempt for each intubation (not mutually exclusive). In addition, data on the reason for failure to intubate on the first attempt was missing for 23 patients in the video laryngoscope group and 40 patients in the direct laryngoscope group. Reason for failure among those who did not meet the primary outcome (successful intubation on the first attempt): * Inadequate view of the larynx * Inability to intubate the trachea with an endotracheal tube * Inability to cannulate the trachea with a bougie * Attempt aborted due to change in patient condition (e.g., worsening hypoxemia, hypotension, bradycardia, vomiting, bleeding) * Technical failure of the laryngoscope (e.g., battery, light source, camera, screen) * Other * Not Reported |
| Other | Operator-reported Aspiration | from induction to 2 minutes following tracheal intubation | |
| Other | Esophageal Intubation | from induction to 2 minutes following tracheal intubation | |
| Other | Injury to the Teeth | from induction to 2 minutes following tracheal intubation |
1 to 10 of 13Source ClinicalTrials.gov
See all 13 registered outcomesOutcomes13
Each outcome the trial posted results for, in ClinicalTrials.gov's words.
| Type | Outcome | Time frame | Population | Units | Measured as |
|---|---|---|---|---|---|
| PRIMARY | Number of Intubations With Successful Intubation on the First Attempt | Duration of procedure (minutes) | Participants | COUNT_OF_PARTICIPANTS | |
| SECONDARY | Number of Participants With Severe Complications of Tracheal Intubation | from induction to 2 minutes following tracheal intubation | Participants | COUNT_OF_PARTICIPANTS | |
| OTHER_PRE_SPECIFIED | Duration of Laryngoscopy and Tracheal Intubation | Duration of procedure (minutes) | Seconds | MEDIAN | |
| OTHER_PRE_SPECIFIED | Number of Laryngoscopy Attempts | Duration of procedure (minutes) | A subset of patients were missing this data variable. | Participants | COUNT_OF_PARTICIPANTS |
| OTHER_PRE_SPECIFIED | Number of Attempts to Cannulate the Trachea With a Bougie or an Endotracheal Tube | Duration of procedure (minutes) | Data was not available for entire patient population. | number of events | NUMBER |
| OTHER_PRE_SPECIFIED | Successful Intubation on the First Attempt Without a Severe Complication | from induction to 2 minutes following tracheal intubation | Participants | COUNT_OF_PARTICIPANTS | |
| OTHER_PRE_SPECIFIED | Reason for Failure to Intubate on the First Attempt | Duration of procedure (minutes) | Participants | COUNT_OF_PARTICIPANTS | |
| OTHER_PRE_SPECIFIED | Operator-reported Aspiration | from induction to 2 minutes following tracheal intubation | Participants | COUNT_OF_PARTICIPANTS | |
| OTHER_PRE_SPECIFIED | Esophageal Intubation | from induction to 2 minutes following tracheal intubation | Participants | COUNT_OF_PARTICIPANTS | |
| OTHER_PRE_SPECIFIED | Injury to the Teeth | from induction to 2 minutes following tracheal intubation | Participants | COUNT_OF_PARTICIPANTS |
1 to 10 of 13Source ClinicalTrials.gov
See all 13 outcomesResults by group54
Each measurement the trial posted, group by group, in the words and numbers it posted.
| Outcome | Group | Category | Value | Spread | Units |
|---|---|---|---|---|---|
| Number of Intubations With Successful Intubation on the First Attempt | Video Laryngoscope Group | 600 | Participants | ||
| Number of Intubations With Successful Intubation on the First Attempt | Direct Laryngoscope Group | 504 | Participants | ||
| Number of Participants With Severe Complications of Tracheal Intubation | Video Laryngoscope Group | 151 | Participants | ||
| Number of Participants With Severe Complications of Tracheal Intubation | Direct Laryngoscope Group | 149 | Participants | ||
| Duration of Laryngoscopy and Tracheal Intubation | Video Laryngoscope Group | 38 | Inter-Quartile Range 26 to 60 | Seconds | |
| Duration of Laryngoscopy and Tracheal Intubation | Direct Laryngoscope Group | 46 | Inter-Quartile Range 30 to 83 | Seconds | |
| Number of Laryngoscopy Attempts | Video Laryngoscope Group | Number of times a laryngoscope entered the patient's mouth (reported by observer) - 1 | 636 | Participants | |
| Number of Laryngoscopy Attempts | Direct Laryngoscope Group | Number of times a laryngoscope entered the patient's mouth (reported by observer) - 1 | 546 | Participants | |
| Number of Laryngoscopy Attempts | Video Laryngoscope Group | Number of times a laryngoscope entered the patient's mouth (reported by observer) - 2 | 54 | Participants | |
| Number of Laryngoscopy Attempts | Direct Laryngoscope Group | Number of times a laryngoscope entered the patient's mouth (reported by observer) - 2 | 127 | Participants |
1 to 10 of 54Source ClinicalTrials.gov
See all 54 results by groupParticipant flow6
How many started, completed or left each group, period by period.
| Period | Milestone | Group | Participants | Units counted |
|---|---|---|---|---|
| Overall Study | STARTED | Video Laryngoscope Group | 707 | |
| Overall Study | STARTED | Direct Laryngoscope Group | 713 | |
| Overall Study | COMPLETED | Video Laryngoscope Group | 705 | |
| Overall Study | COMPLETED | Direct Laryngoscope Group | 712 | |
| Overall Study | NOT COMPLETED | Video Laryngoscope Group | 2 | |
| Overall Study | NOT COMPLETED | Direct Laryngoscope Group | 1 |
Source ClinicalTrials.gov
Adverse events0
Each adverse event the trial posted, group by group: the participants affected out of those at risk.
None in this release.
Adverse event totals6
The totals the trial posted for each group.
| Total | Group | Affected | At risk |
|---|---|---|---|
| Total, all-cause mortality | Video Laryngoscope Group | 184 | 705 |
| Total, all-cause mortality | Direct Laryngoscope Group | 191 | 712 |
| Total, other adverse events | Video Laryngoscope Group | 0 | 705 |
| Total, other adverse events | Direct Laryngoscope Group | 0 | 712 |
| Total, serious adverse events | Video Laryngoscope Group | 0 | 705 |
| Total, serious adverse events | Direct Laryngoscope Group | 0 | 712 |
Source ClinicalTrials.gov
Papers2
The papers the trial lists on ClinicalTrials.gov.
Grants0
The grants NIH RePORTER links to the trial, newest funded first: NIH's, and some of AHRQ's, CDC's, FDA's and VA's. Each shows its title, principal investigators, organization and funder in its newest year.
None in this release.
Trial comparisons9
Comparisons of the trial's two groups, calculated by ConductScience from the counts it posted.
| Comparison | Source |
|---|---|
| Video Laryngoscope Group vs Direct Laryngoscope Group: Operator-reported Aspiration | Trial comparisons |
| Video Laryngoscope Group vs Direct Laryngoscope Group: Number of Participants With Severe Complications of Tracheal Intubation | Trial comparisons |
| Video Laryngoscope Group vs Direct Laryngoscope Group: All-cause In-hospital Mortality | Trial comparisons |
| Video Laryngoscope Group vs Direct Laryngoscope Group: Injury to the Teeth | Trial comparisons |
| Video Laryngoscope Group vs Direct Laryngoscope Group: Number of Intubations With Successful Intubation on the First Attempt | Trial comparisons |
| Video Laryngoscope Group vs Direct Laryngoscope Group: Successful Intubation on the First Attempt Without a Severe Complication | Trial comparisons |
| Video Laryngoscope Group vs Direct Laryngoscope Group: deaths from any cause | Trial comparisons |
| Video Laryngoscope Group vs Direct Laryngoscope Group: Esophageal Intubation | Trial comparisons |
| Video Laryngoscope Group vs Direct Laryngoscope Group: serious adverse events | Trial comparisons |
Tests0
The ConductCognition tests this trial's registered outcomes name, as ScienceGraph matched them in trial-tests-2026-11-12-0.2.1.
None in this release.
Data dates
The day each source was copied for this release.
Sources 3
- ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
- ClinicalTrials.govNo license stated
- NIH RePORTER's clinical studies and project filesPublic domain
Each source's terms
- ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
- ClinicalTrials.govnone stated
- NIH RePORTER's clinical studies and project filesPublic domain (NIH RePORTER)
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.
For software
Read this trial from software.
The record and each of its lists are JSON, twenty rows a page. No key.
GET https://conductscience.org/api/trials/v1/NCT05239195
GET https://conductscience.org/api/trials/v1/NCT05239195/results?page=2