Trial · NCT05275374
XP-102 and XP-102 in Combination With Trametinib in Advanced Solid Tumor Patients With a BRAF V600 Mutation
NCT05275374, Phase 1, Phase 2, Not yet recruiting, Xynomic Pharmaceuticals, Inc.
3 sourcestrials-2026-11-12-0.5.0
Cite this record
ConductScience Library. XP-102 and XP-102 in Combination With Trametinib in Advanced Solid Tumor Patients With a BRAF V600 Mutation. Trials, record NCT05275374. Release trials-2026-11-12-0.5.0, 12 Nov 2026. https://conductscience.org/library/trials/NCT05275374
On this page
Trial
As registered on ClinicalTrials.gov, in the graph's capture of the registry.
- Title
- XP-102 and XP-102 in Combination With Trametinib in Advanced Solid Tumor Patients With a BRAF V600 Mutation
- NCT number
- NCT05275374
- Status
- Not yet recruiting
- Phases
- Phase 1, Phase 2
- Enrollment
- 221 participants, estimated
- Lead sponsor
- Xynomic Pharmaceuticals, Inc.
- Conditions
- Cancer, BRAF V600 Mutation, Melanoma, Colorectal Cancer, Thyroid Cancer, Nonsmall Cell Lung Cancer
- Interventions
- XP-102, Trametinib
- First posted
- 2022-03-11
- Last updated
- 2025-04-10
Source ClinicalTrials.gov
Registered outcomes7
Each outcome the trial registered, primary first, in ClinicalTrials.gov's words.
| List | Outcome | Time frame | Description |
|---|---|---|---|
| Primary | Characterize the safety of XP-102. | 28 days | Number of participants with treatment related adverse events. |
| Primary | Evaluate the pharmacokinetics of XP-102. | 28 days | Blood plasma concentration. |
| Primary | Establish maximum tolerated dose of XP-102. | 28 days | Number of participants with dose limiting toxicity |
| Secondary | Evaluate the pharmacokinetics of XP-102 + trametinib. | 28 days | Blood plasma concentration. |
| Secondary | Characterize tolerability of XP-102 in combination with trametinib. | 28 days | Number of participants with dose limiting toxicity |
| Secondary | Evaluate the pharmacokinetics of XP-102 administered with food | 4 days | Blood plasma concentration. |
| Secondary | Evaluate clinical activity/efficacy of XP-102. | Approximately every 8 weeks (up to 2 years) | Overall Response Rate with RECIST criteria v1.1. |
Source ClinicalTrials.gov
Outcomes0
Each outcome the trial posted results for, in ClinicalTrials.gov's words.
None in this release.
Results by group0
Each measurement the trial posted, group by group, in the words and numbers it posted.
None in this release.
Participant flow0
How many started, completed or left each group, period by period.
None in this release.
Adverse events0
Each adverse event the trial posted, group by group: the participants affected out of those at risk.
None in this release.
Adverse event totals0
The totals the trial posted for each group.
None in this release.
Papers0
The papers the trial lists on ClinicalTrials.gov.
None in this release.
Grants0
The grants NIH RePORTER links to the trial, newest funded first: NIH's, and some of AHRQ's, CDC's, FDA's and VA's. Each shows its title, principal investigators, organization and funder in its newest year.
None in this release.
Trial comparisons0
Comparisons of the trial's two groups, calculated by ConductScience from the counts it posted.
None in this release.
Tests0
The ConductCognition tests this trial's registered outcomes name, as ScienceGraph matched them in trial-tests-2026-11-12-0.2.1.
None in this release.
Data dates
The day each source was copied for this release.
Sources 3
- ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
- ClinicalTrials.govNo license stated
- NIH RePORTER's clinical studies and project filesPublic domain
Each source's terms
- ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
- ClinicalTrials.govnone stated
- NIH RePORTER's clinical studies and project filesPublic domain (NIH RePORTER)
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.
For software
Read this trial from software.
The record and each of its lists are JSON, twenty rows a page. No key.
GET https://conductscience.org/api/trials/v1/NCT05275374
GET https://conductscience.org/api/trials/v1/NCT05275374/registered