Trial · NCT05277896
Randomized Trial of Sedative Choice for Intubation
NCT05277896, Phase 4, Completed, Vanderbilt University Medical Center
3 sourcestrials-2026-11-12-0.5.0
Cite this record
ConductScience Library. Randomized Trial of Sedative Choice for Intubation. Trials, record NCT05277896. Release trials-2026-11-12-0.5.0, 12 Nov 2026. https://conductscience.org/library/trials/NCT05277896
On this page
Trial
As registered on ClinicalTrials.gov, in the graph's capture of the registry.
- Title
- Randomized Trial of Sedative Choice for Intubation
- NCT number
- NCT05277896
- Status
- Completed
- Phases
- Phase 4
- Enrollment
- 2,367 participants, actual
- Lead sponsor
- Vanderbilt University Medical Center
- Conditions
- Acute Respiratory Failure
- Interventions
- Ketamine, Etomidate
- First posted
- 2022-03-14
- Last updated
- 2026-03-25
Source ClinicalTrials.gov
Registered outcomes19
Each outcome the trial registered, primary first, in ClinicalTrials.gov's words.
| List | Outcome | Time frame | Description |
|---|---|---|---|
| Primary | All-cause, 28-day, In-hospital Mortality | 28 days | |
| Secondary | Cardiovascular Collapse | from induction to 2 minutes following tracheal intubation | A composite of any of the following between induction and 2 minutes after intubation: * Systolic blood pressure \< 65 mmHg * New or increased vasopressors * Cardiac arrest not resulting in death within 1 hour of induction * Cardiac arrest resulting in death within 1 hour of induction |
| Other | Cormack-Lehane Grade of Glottic View | Duration of procedure (minutes) | Grade of glottic view on first attempt at intubation: Grade 1: Full view of glottis Grade 2: Partial view of glottis Grade 3: Only epiglottis seen (none of glottis) Grade 4: Neither glottis nor epiglottis seen |
| Other | Time From Induction to Successful Tracheal Intubation | Duration of procedure (minutes) | Median time from induction of anesthesia to intubation |
| Other | Lowest Oxygen Saturation Between Induction and Two Minutes After Intubation | from induction to 2 minutes following tracheal intubation | Percentage of oxygenated hemoglobin |
| Other | Lowest Oxygen Saturation < 80% Between Induction to Two Minutes After Intubation | from induction to 2 minutes following tracheal intubation | |
| Other | Highest and Lowest Systolic Blood Pressure From Induction to Two Minutes After Intubation | from induction to 2 minutes following tracheal intubation | Median highest and lowest systolic blood pressure from induction to two minutes after intubation |
| Other | Systolic Blood Pressure > 180 Between Induction and Two Minutes After Intubation | from induction to 2 minutes following tracheal intubation | |
| Other | Systolic Blood Pressure < 65 mmHg Between Induction and 2 Minutes After Intubation | from induction to 2 minutes following tracheal intubation | |
| Other | New or Increased Vasopressor Between Induction and 2 Minutes After Intubation | from induction to 2 minutes following tracheal intubation | Receipt of new or increased vasopressor between induction and 2 minutes after intubation |
1 to 10 of 19Source ClinicalTrials.gov
See all 19 registered outcomesOutcomes0
Each outcome the trial posted results for, in ClinicalTrials.gov's words.
None in this release.
Results by group0
Each measurement the trial posted, group by group, in the words and numbers it posted.
None in this release.
Participant flow0
How many started, completed or left each group, period by period.
None in this release.
Adverse events0
Each adverse event the trial posted, group by group: the participants affected out of those at risk.
None in this release.
Adverse event totals0
The totals the trial posted for each group.
None in this release.
Papers4
The papers the trial lists on ClinicalTrials.gov.
Grants1
The grants NIH RePORTER links to the trial, newest funded first: NIH's, and some of AHRQ's, CDC's, FDA's and VA's. Each shows its title, principal investigators, organization and funder in its newest year.
| Project | Title | Principal investigators | Organization | Funder | Fiscal years |
|---|---|---|---|---|---|
| K23HL153584 | Bag-Mask Ventilation to PreVent Hypoxemia during Tracheal Intubation in the Emergency Department: A Clinical Trial | CASEY, JONATHAN DALE | VANDERBILT UNIVERSITY MEDICAL CENTER | NATIONAL HEART, LUNG, AND BLOOD INSTITUTE | 2020 to 2024 |
Source NIH RePORTER
Trial comparisons0
Comparisons of the trial's two groups, calculated by ConductScience from the counts it posted.
None in this release.
Tests0
The ConductCognition tests this trial's registered outcomes name, as ScienceGraph matched them in trial-tests-2026-11-12-0.2.1.
None in this release.
Data dates
The day each source was copied for this release.
Sources 3
- ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
- ClinicalTrials.govNo license stated
- NIH RePORTER's clinical studies and project filesPublic domain
Each source's terms
- ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
- ClinicalTrials.govnone stated
- NIH RePORTER's clinical studies and project filesPublic domain (NIH RePORTER)
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.
For software
Read this trial from software.
The record and each of its lists are JSON, twenty rows a page. No key.
GET https://conductscience.org/api/trials/v1/NCT05277896
GET https://conductscience.org/api/trials/v1/NCT05277896/registered