Trial · NCT05284656
Effect of Folic Acid and/or Pentoxifylline on Patients With Chronic Kidney Disease
NCT05284656, Phase 3, Active not recruiting, Al-Azhar University; results first posted 2025-06-11
3 sourcestrials-2026-11-12-0.5.0
Cite this record
ConductScience Library. Effect of Folic Acid and/or Pentoxifylline on Patients With Chronic Kidney Disease. Trials, record NCT05284656. Release trials-2026-11-12-0.5.0, 12 Nov 2026. https://conductscience.org/library/trials/NCT05284656
On this page
Trial
As registered on ClinicalTrials.gov, in the graph's capture of the registry.
- Title
- Effect of Folic Acid and/or Pentoxifylline on Patients With Chronic Kidney Disease
- NCT number
- NCT05284656
- Status
- Active not recruiting
- Phases
- Phase 3
- Enrollment
- 80 participants, actual
- Lead sponsor
- Al-Azhar University
- Conditions
- Chronic Kidney Diseases
- Interventions
- combination of Pentoxifylline 400 MG and Folic Acid, folic acid, Pentoxifylline 400 MG
- First posted
- 2022-03-17
- Last updated
- 2025-06-11
- Results first posted
- 2025-06-11
Source ClinicalTrials.gov
Registered outcomes3
Each outcome the trial registered, primary first, in ClinicalTrials.gov's words.
| List | Outcome | Time frame | Description |
|---|---|---|---|
| Primary | Change in Serum Creatinine Level | Baseline, 6 months | Change was calculated as the value at 6 months minus the value at baseline. |
| Secondary | Serum Ferritin in ng/ml | 6 months | increase in serum ferritin from baseline |
| Other | Protein/ Creatinine Ratio(P/C) (mg Protein/mg Creatinine) | 6 months | change in Protein/ creatinine ratio for determination of proteinuria |
Source ClinicalTrials.gov
Outcomes3
Each outcome the trial posted results for, in ClinicalTrials.gov's words.
| Type | Outcome | Time frame | Population | Units | Measured as |
|---|---|---|---|---|---|
| PRIMARY | Change in Serum Creatinine Level | Baseline, 6 months | mg/dl | MEAN | |
| SECONDARY | Serum Ferritin in ng/ml | 6 months | ng/ml | MEAN | |
| OTHER_PRE_SPECIFIED | Protein/ Creatinine Ratio(P/C) (mg Protein/mg Creatinine) | 6 months |
Source ClinicalTrials.gov
Results by group8
Each measurement the trial posted, group by group, in the words and numbers it posted.
| Outcome | Group | Category | Value | Spread | Units |
|---|---|---|---|---|---|
| Change in Serum Creatinine Level | Folic Acid Group | 3.118 | Standard Deviation 1.203 | mg/dl | |
| Change in Serum Creatinine Level | Pentoxifylline Group | 3.335 | Standard Deviation 1.149 | mg/dl | |
| Change in Serum Creatinine Level | Folic Acid and Pentoxifylline Group | 3.535 | Standard Deviation 0.9109 | mg/dl | |
| Change in Serum Creatinine Level | Control Group | 2.872 | Standard Deviation 0.8901 | mg/dl | |
| Serum Ferritin in ng/ml | Folic Acid Group | 200.6 | Standard Deviation 66.18 | ng/ml | |
| Serum Ferritin in ng/ml | Pentoxifylline Group | 334.1 | Standard Deviation 230.2 | ng/ml | |
| Serum Ferritin in ng/ml | Folic Acid and Pentoxifylline Group | 245.1 | Standard Deviation 115.7 | ng/ml | |
| Serum Ferritin in ng/ml | Control Group | 235.3 | Standard Deviation 185.1 | ng/ml |
Source ClinicalTrials.gov
Participant flow12
How many started, completed or left each group, period by period.
| Period | Milestone | Group | Participants | Units counted |
|---|---|---|---|---|
| Overall Study | STARTED | Folic Acid Group | 20 | |
| Overall Study | STARTED | Pentoxifylline Group | 20 | |
| Overall Study | STARTED | Folic Acid and Pentoxifylline Group | 20 | |
| Overall Study | STARTED | Control Group | 20 | |
| Overall Study | COMPLETED | Folic Acid Group | 20 | |
| Overall Study | COMPLETED | Pentoxifylline Group | 20 | |
| Overall Study | COMPLETED | Folic Acid and Pentoxifylline Group | 20 | |
| Overall Study | COMPLETED | Control Group | 20 | |
| Overall Study | NOT COMPLETED | Folic Acid Group | 0 | |
| Overall Study | NOT COMPLETED | Pentoxifylline Group | 0 |
1 to 10 of 12Source ClinicalTrials.gov
See all 12 participant flowAdverse events0
Each adverse event the trial posted, group by group: the participants affected out of those at risk.
None in this release.
Adverse event totals12
The totals the trial posted for each group.
| Total | Group | Affected | At risk |
|---|---|---|---|
| Total, all-cause mortality | Folic Acid Group | 0 | 20 |
| Total, all-cause mortality | Pentoxifylline Group | 0 | 20 |
| Total, all-cause mortality | Folic Acid and Pentoxifylline Group | 0 | 20 |
| Total, all-cause mortality | Control Group | 0 | 20 |
| Total, other adverse events | Folic Acid Group | 0 | 20 |
| Total, other adverse events | Pentoxifylline Group | 0 | 20 |
| Total, other adverse events | Folic Acid and Pentoxifylline Group | 0 | 20 |
| Total, other adverse events | Control Group | 0 | 20 |
| Total, serious adverse events | Folic Acid Group | 0 | 20 |
| Total, serious adverse events | Pentoxifylline Group | 0 | 20 |
1 to 10 of 12Source ClinicalTrials.gov
See all 12 adverse event totalsPapers1
The papers the trial lists on ClinicalTrials.gov.
| PMID | Listed as |
|---|---|
| 40826392 | DERIVED |
Source PubMed
Grants0
The grants NIH RePORTER links to the trial, newest funded first: NIH's, and some of AHRQ's, CDC's, FDA's and VA's. Each shows its title, principal investigators, organization and funder in its newest year.
None in this release.
Trial comparisons0
Comparisons of the trial's two groups, calculated by ConductScience from the counts it posted.
None in this release.
Tests0
The ConductCognition tests this trial's registered outcomes name, as ScienceGraph matched them in trial-tests-2026-11-12-0.2.1.
None in this release.
Data dates
The day each source was copied for this release.
Sources 3
- ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
- ClinicalTrials.govNo license stated
- NIH RePORTER's clinical studies and project filesPublic domain
Each source's terms
- ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
- ClinicalTrials.govnone stated
- NIH RePORTER's clinical studies and project filesPublic domain (NIH RePORTER)
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.
For software
Read this trial from software.
The record and each of its lists are JSON, twenty rows a page. No key.
GET https://conductscience.org/api/trials/v1/NCT05284656
GET https://conductscience.org/api/trials/v1/NCT05284656/registered