Neuroplasticity in Parkinson's Disease
NCT05286736, Completed, University of Minnesota
Trial 9
As registered on ClinicalTrials.gov, in the graph's capture of the registry.
| Field | Value | Source |
|---|---|---|
| Title | Neuroplasticity in Parkinson's Disease | ClinicalTrials.gov |
| NCT number | NCT05286736 | ClinicalTrials.gov |
| Status | Completed | ClinicalTrials.gov |
| Enrollment | 42 participants, actual | ClinicalTrials.gov |
| Lead sponsor | University of Minnesota | ClinicalTrials.gov |
| Conditions | Parkinson, Parkinson Disease | ClinicalTrials.gov |
| Interventions | Neuroimaging, Quantitative assessments | ClinicalTrials.gov |
| First posted | 2022-03-18 | ClinicalTrials.gov |
| Last updated | 2026-11-03 | ClinicalTrials.gov |
Registered outcomes 10
Each outcome the trial registered, primary first, in ClinicalTrials.gov's words.
| List | Outcome | Time frame | Description | Source |
|---|---|---|---|---|
| Primary | Change in volume of Subthalamic Nucleus | Baseline, 30-36 months | The volume of the subthalamic nucleus is assessed using MRI and reported in millimeters cubed (mm\^3). | ClinicalTrials.gov |
| Primary | Change in fractional Anisotropy of Subthalamic Nucleus | Baseline, 30-36 months | Fractional anisotropy, measured using MRI, is a unit-less value between zero and one that describes the degree of anisotropy of water diffusion in a specified brain area. Higher values indicate a greater degree of anisotropy, while a score of zero indicates isotropic diffusion. | ClinicalTrials.gov |
| Primary | Change in cortico-STN Connectivity | Baseline, 30-36 months | Cortico-Subthalamic nucleus connectivity is measured using MRI and reported as a z score (unitless). | ClinicalTrials.gov |
| Primary | Change in paired Associative Stimulation-Motor Evoked Potential (PAS-MEP) | Baseline, 30-36 months | Motor evoked potential is measured as the amplitude of change in target muscle electrical activity following transcranial magnetic stimulation (TMS) and reported in units of millivolts (mV). | ClinicalTrials.gov |
| Primary | Change in Mattis Dementia Rating Scale 2 (DRS-2) | Baseline, 30-36 months | The DRS-2 consists of 24 items, rated on a scale from 0 to 6. Item scores are combined into five subscales: attention (8 items), initiation/perseveration (11 items), construction (6 items), conceptualization ( 6 items), and memory (5 items). These five subscale scores are summed to calculate a total score ranging from from 0 to 144 points, with lower scores indicating worse performance due to dementia. | ClinicalTrials.gov |
| Primary | Change in Rey Complex Figure and Matrix Reasoning of the Wechsler Adult Intelligence Scale - IV | Baseline, 30-36 months | Measure of visuospatial construction, memory and reasoning. Scaled score based on age norms. | ClinicalTrials.gov |
| Primary | Change in Stroop Color Word Test | Baseline, 30-36 months | Measure of response inhibition, selective attention and processing. Scaled score based on age norms. | ClinicalTrials.gov |
| Primary | Change in Wisconsin Card Sorting Test | Baseline, 30-36 months | Measures cognitive flexibility, abstract reasoning, and set-shifting. Scaled score based on age norms. | ClinicalTrials.gov |
| Primary | Change in Delis-Kaplan Executive Function System (D-KEFS) Verbal Fluency Subtest | Baseline, 30-36 months | Measures cognitive flexibility, abstract reasoning, and set-shifting. Scaled score based on age norms. | ClinicalTrials.gov |
| Primary | Change in Brief Visuospatial Memory Test - Revised (BVMT-R) | Baseline, 30-36 months | Measure of non-verbal (visuospatial) learning and memory abilities. Scaled score based on age norms. | ClinicalTrials.gov |
Outcomes 0
Each outcome the trial posted results for, in ClinicalTrials.gov's words.
| Type | Outcome | Time frame | Population | Units | Measured as | Source |
|---|
Results by group 0
Each measurement the trial posted, group by group, in the words and numbers it posted.
| Outcome | Group | Category | Value | Spread | Units | Source |
|---|
Participant flow 0
How many started, completed or left each group, period by period.
| Period | Milestone | Group | Participants | Units counted | Source |
|---|
Adverse events 0
Each adverse event the trial posted, group by group: the participants affected out of those at risk.
| Type | Event | Organ system | Group | Affected | At risk | Events | Source |
|---|
Adverse event totals 0
The totals the trial posted for each group.
| Total | Group | Affected | At risk | Source |
|---|
Papers 0
The papers the trial lists on ClinicalTrials.gov.
| PMID | Listed as | Source |
|---|
Grants 0
The grants NIH RePORTER links to the trial, newest funded first: NIH's, and some of AHRQ's, CDC's, FDA's and VA's. Each shows its title, principal investigators, organization and funder in its newest year.
| Project | Title | Principal investigators | Organization | Funder | Fiscal years | Source |
|---|
Trial comparisons 0
Comparisons of the trial's two groups, calculated by ConductScience from the counts it posted.
| Comparison | Source |
|---|
Tests 5
The ConductCognition tests this trial's registered outcomes name, as ScienceGraph matched them in trial-tests-2026-11-12-0.2.1.
| Test | Named as | Source |
|---|---|---|
| Card Sorting Test (Berg) | Primary outcome | ConductCognition |
| Complex Figure Copy and Recall | Primary outcome | ConductCognition |
| Matrix Reasoning | Primary outcome | ConductCognition |
| Stroop Color-Word Test | Primary outcome | ConductCognition |
| Verbal Fluency | Primary outcome | ConductCognition |
Source 5
| Field | Value | Source |
|---|---|---|
| Release | trials-2026-11-12-0.4.0 | ClinicalTrials.gov |
| Release manifest SHA-256 | 0f4a8d8c48aee2a7573ae0fa94ecbeab70c1adbe449bbc95c424bc7d3e97b9d4 | ClinicalTrials.gov |
| Registry capture | 2026-11-12 | ClinicalTrials.gov |
| Results copy, AACT | 2026-03-23 | ClinicalTrials.gov |
| NIH clinical studies file | 2026-11-13 | ClinicalTrials.gov |
Release trials-2026-11-12-0.4.0
ClinicalTrials.gov's posted results, through CTTI's AACT: ClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299 ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.
ClinicalTrials.gov: none stated ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.
NIH RePORTER's clinical studies and project files: Public domain (NIH RePORTER)