Registered outcomes11

Each outcome the trial registered, primary first, in ClinicalTrials.gov's words.

1 to 11 of 11

List	Outcome	Time frame	Description
Primary	Clearance of caffeine	1 week	Clearance (mL h-1 kg-1)
Primary	Volume of distribution of caffeine	1 week	Volume of distribution (ml/kg)
Primary	Peak plasma concentration (Cmax) of caffeine	1 week	Peak plasma concentration (Cmax) (ng/mL)
Primary	Area under the plasma concentration-time curve of caffeine	1 week	Area under the plasma concentration-time curve from 0 to infinity (AUC0-INF) (mg\*h/L)
Primary	Seizure incidence	2 weeks	Number of neonates who developed seizures based on continuous video electroencephalogram (VEEG) data
Primary	Seizure burden	2 weeks	Electrographic seizures (in minutes per hour) based on continuous video electroencephalogram (VEEG) data
Secondary	Acute kidney injury	10 days	AKI incidence utilizing KDIGO criteria based on urine output and SCr.
Secondary	Renal near infrared spectroscopy (NIRS)	5 days	Investigate changes in renal NIRS values during the therapeutic hypothermia and rewarming period.
Secondary	Urine neutrophil gelatinase-associated lipocalin (NGAL) (ng/mL)	3 days	Urine samples will be collected at 24, 48 and 72 hours after birth. Urine will be analyzed for NGAL.
Secondary	Urine kidney injury molecule-1 (KIM-1) (pg/mL)	3 days	Urine samples will be collected at 24, 48 and 72 hours after birth. Urine will be analyzed for KIM-1.
Secondary	Urine interleukin-18 (IL-18) (pg/mL)	3 days	Urine samples will be collected at 24, 48 and 72 hours after birth. Urine will be analyzed for IL-18.

Source ClinicalTrials.govtrials-2026-11-12-0.5.0

Sources 3

ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
ClinicalTrials.govNo license stated
NIH RePORTER's clinical studies and project filesPublic domain

Each source's terms

ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
ClinicalTrials.govnone stated
NIH RePORTER's clinical studies and project filesPublic domain (NIH RePORTER)

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

For software

Twenty rows a page, as JSON. No key.

GET https://conductscience.org/api/trials/v1/NCT05295784/registered