Trial · NCT05324735
Pentoxifylline for Treatment of Resistant Major Depression
NCT05324735, Phase 1, Phase 2, Completed, Hawler Medical University
3 sourcestrials-2026-11-12-0.5.0
Cite this record
ConductScience Library. Pentoxifylline for Treatment of Resistant Major Depression. Trials, record NCT05324735. Release trials-2026-11-12-0.5.0, 12 Nov 2026. https://conductscience.org/library/trials/NCT05324735
On this page
Trial
As registered on ClinicalTrials.gov, in the graph's capture of the registry.
- Title
- Pentoxifylline for Treatment of Resistant Major Depression
- NCT number
- NCT05324735
- Status
- Completed
- Phases
- Phase 1, Phase 2
- Enrollment
- 60 participants, actual
- Lead sponsor
- Hawler Medical University
- Conditions
- Resistant Major Depression
- Interventions
- Pentoxifylline, Placebo
- First posted
- 2022-04-12
- Last updated
- 2022-09-07
Source ClinicalTrials.gov
Registered outcomes6
Each outcome the trial registered, primary first, in ClinicalTrials.gov's words.
| List | Outcome | Time frame | Description |
|---|---|---|---|
| Primary | Hamilton Depression Rating Scale-17 (HAM-D-17) Scores | 12 weeks | The HAM-D-17 is a 17-item scale that asks participants to rate the severity of their depression symptoms. Scoring is based on the 17-item scale. The total score ranges from 0 to 52, with higher numbers demonstrating more severe symptoms. Normal scores range from 0 to 7, mild depression ranges from 8 to 16, moderate depression ranges from 17 to 23, and scores of 24 and greater indicate severe depression. Remission is defined as HAM-D-17 total score ≤ 7 (primary outcome). |
| Secondary | Response Rate | 12 weeks | The number of patients with a ≥ 50% drop in the Hamilton Depression Rating Scale-17 (HAM-D-17) total score. |
| Secondary | Remission Rate | 12 weeks | The number of patients reaching depression remission. Remission is defined as Hamilton Depression Rating Scale-17 (HAM-D-17) total score ≤ 7. |
| Secondary | Serum level of CRP | 12 weeks | Peripheral blood samples will be collected to assess changes in the serum levels of C- reactive protein (mg/dl). |
| Secondary | Serum level of TNF-α | 12 weeks | Peripheral blood samples will be collected to assess changes in the serum levels of tumor necrosis factor alpha (pg/ml). |
| Secondary | Serum level of IL-6 | 12 weeks | Peripheral blood samples will be collected to assess changes in the serum levels of Interleukin-6 (pg/ml). |
Source ClinicalTrials.gov
Outcomes0
Each outcome the trial posted results for, in ClinicalTrials.gov's words.
None in this release.
Results by group0
Each measurement the trial posted, group by group, in the words and numbers it posted.
None in this release.
Participant flow0
How many started, completed or left each group, period by period.
None in this release.
Adverse events0
Each adverse event the trial posted, group by group: the participants affected out of those at risk.
None in this release.
Adverse event totals0
The totals the trial posted for each group.
None in this release.
Papers0
The papers the trial lists on ClinicalTrials.gov.
None in this release.
Grants0
The grants NIH RePORTER links to the trial, newest funded first: NIH's, and some of AHRQ's, CDC's, FDA's and VA's. Each shows its title, principal investigators, organization and funder in its newest year.
None in this release.
Trial comparisons0
Comparisons of the trial's two groups, calculated by ConductScience from the counts it posted.
None in this release.
Tests0
The ConductCognition tests this trial's registered outcomes name, as ScienceGraph matched them in trial-tests-2026-11-12-0.2.1.
None in this release.
Data dates
The day each source was copied for this release.
Sources 3
- ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
- ClinicalTrials.govNo license stated
- NIH RePORTER's clinical studies and project filesPublic domain
Each source's terms
- ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
- ClinicalTrials.govnone stated
- NIH RePORTER's clinical studies and project filesPublic domain (NIH RePORTER)
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.
For software
Read this trial from software.
The record and each of its lists are JSON, twenty rows a page. No key.
GET https://conductscience.org/api/trials/v1/NCT05324735
GET https://conductscience.org/api/trials/v1/NCT05324735/registered