Trial · NCT05347238
Dopamine vs. Norepinephrine for Hypotension in Very Preterm Infants With Late-onset Sepsis
NCT05347238, Recruiting, Mount Sinai Hospital, Canada
3 sourcestrials-2026-11-12-0.5.0
Cite this record
ConductScience Library. Dopamine vs. Norepinephrine for Hypotension in Very Preterm Infants With Late-onset Sepsis. Trials, record NCT05347238. Release trials-2026-11-12-0.5.0, 12 Nov 2026. https://conductscience.org/library/trials/NCT05347238
On this page
Trial
As registered on ClinicalTrials.gov, in the graph's capture of the registry.
- Title
- Dopamine vs. Norepinephrine for Hypotension in Very Preterm Infants With Late-onset Sepsis
- NCT number
- NCT05347238
- Status
- Recruiting
- Enrollment
- 550 participants, estimated
- Lead sponsor
- Mount Sinai Hospital, Canada
- Conditions
- Late-Onset Neonatal Sepsis, Extreme Prematurity, Neonatal Hypotension
- Interventions
- Dopamine, Norepinephrine
- First posted
- 2022-04-26
- Last updated
- 2026-10-16
Source ClinicalTrials.gov
Registered outcomes7
Each outcome the trial registered, primary first, in ClinicalTrials.gov's words.
| List | Outcome | Time frame | Description |
|---|---|---|---|
| Primary | All cause in-hospital mortality | From illness onset to discharge (home or to another hospital) - assessed up to a maximum of 36 weeks after date of birth | Death before discharge |
| Secondary | Episode-related death | <14 days from illness onset | Episode-related death (yes or no- binary variable) |
| Secondary | Treatment failure rate | 90 minutes after initial vasopressor initiation (or sooner if secondary dose added or primary agent replaced as per clinical discretion) | Need for further dose escalation or use of additional agents (treatment failure = hypotension unresolved after reaching max dose (15mics/kg/min in Dopamine units and 0.15 mics/kg/min in Norepinephrine units) |
| Secondary | New diagnosis of severe neurological injury | From illness onset to discharge (home or to another hospital) - assessed up to a maximum of 36 weeks after date of birth | Grade III or Grade IV intraventricular hemorrhage or periventricular leukomalacia (yes or no- binary variable) |
| Secondary | Bronchopulmonary dysplasia | Assessed at 36 weeks PMA | Need for oxygen or positive pressure respiratory support at 36 weeks postmenstrual age (PMA) (yes or no- binary variable) |
| Secondary | Retinopathy of prematurity | From illness onset to discharge (home or to another hospital) - assessed up to a maximum of 36 weeks after date of birth | Diagnosis of retinopathy of prematurity - assessed by clinical staff (yes or no - binary variable) |
| Secondary | Length of hospital stay | From admission date to discharge date - assessed up to a maximum of 36 weeks after date of birth | Length of entire neonatal intensive care unit stay from admission to discharge |
Source ClinicalTrials.gov
Outcomes0
Each outcome the trial posted results for, in ClinicalTrials.gov's words.
None in this release.
Results by group0
Each measurement the trial posted, group by group, in the words and numbers it posted.
None in this release.
Participant flow0
How many started, completed or left each group, period by period.
None in this release.
Adverse events0
Each adverse event the trial posted, group by group: the participants affected out of those at risk.
None in this release.
Adverse event totals0
The totals the trial posted for each group.
None in this release.
Papers0
The papers the trial lists on ClinicalTrials.gov.
None in this release.
Grants0
The grants NIH RePORTER links to the trial, newest funded first: NIH's, and some of AHRQ's, CDC's, FDA's and VA's. Each shows its title, principal investigators, organization and funder in its newest year.
None in this release.
Trial comparisons0
Comparisons of the trial's two groups, calculated by ConductScience from the counts it posted.
None in this release.
Tests0
The ConductCognition tests this trial's registered outcomes name, as ScienceGraph matched them in trial-tests-2026-11-12-0.2.1.
None in this release.
Data dates
The day each source was copied for this release.
Sources 3
- ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
- ClinicalTrials.govNo license stated
- NIH RePORTER's clinical studies and project filesPublic domain
Each source's terms
- ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
- ClinicalTrials.govnone stated
- NIH RePORTER's clinical studies and project filesPublic domain (NIH RePORTER)
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.
For software
Read this trial from software.
The record and each of its lists are JSON, twenty rows a page. No key.
GET https://conductscience.org/api/trials/v1/NCT05347238
GET https://conductscience.org/api/trials/v1/NCT05347238/registered