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Trial · NCT05355337

Registered outcomes45

Each outcome the trial registered, primary first, in ClinicalTrials.gov's words.

ListOutcomeTime frameDescription
SecondaryAdverse events9 weeksNumber and severity of adverse events
SecondaryEffect on task-based brain signal variability in the reward circuit9 weeks
BOLD-signaling during functional magnetic resonance imaging (fMRI) with Monetary Incentive Delay (MID)-task measuring Blood-Oxygen Level Dependent (BOLD) imaging pre/post treatment: Change in BOLD signals in nucleus accumbens from baseline to week 9
SecondaryL-DOPA, blood: biomarker of dopaminergic neurotransmission9 weeksChange in levels of L-DOPA in blood sample from baseline to week 9
SecondaryL-DOPA, CSF: biomarker of dopaminergic neurotransmission9 weeksChange in levels of L-DOPA in cerebrospinal fluid sample from baseline to week 9
SecondaryHomovanillic acid, blood: biomarker of dopaminergic neurotransmission9 weeksChange in levels of homovanillic acid in blood sample from baseline to week 9
SecondaryHomovanillic acid, CSF: biomarker of dopaminergic neurotransmission9 weeksChange in levels of homovanillic acid in cerebrospinal fluid sample from baseline to week 9
SecondaryBH4, blood: biomarker of dopaminergic neurotransmission9 weeksChange in levels of tetrahydrobiopterin (BH4) in blood sample from baseline to week 9
SecondaryBH4, CSF: biomarker of dopaminergic neurotransmission9 weeksChange in levels of tetrahydrobiopterin (BH4) in cerebrospinal fluid sample from baseline to week 9
SecondaryTyrosine, blood: biomarker of dopaminergic neurotransmission9 weeksChange in levels of tyrosine in blood sample from baseline to week 9
SecondaryTyrosine, CSF: biomarker of dopaminergic neurotransmission9 weeksChange in levels of tyrosine in cerebrospinal fluid sample from baseline to week 9
SecondaryPhenylalanine, blood: biomarker of dopaminergic neurotransmission9 weeksChange in levels of phenylalanine in blood sample from baseline to week 9
SecondaryPhenylalanine, CSF: biomarker of dopaminergic neurotransmission9 weeksChange in levels of phenylalanine in cerebrospinal fluid sample from baseline to week 9
SecondaryIL-6, blood: biomarker of inflammation9 weeksChange in levels of interleukin-6 (IL-6) in blood sample from baseline to week 9
SecondaryIL-6, CSF: biomarker of inflammation9 weeksChange in levels of interleukin-6 (IL-6) in cerebrospinal fluid sample from baseline to week 9
SecondaryIL-1b, blood: biomarker of inflammation9 weeksChange in levels of interleukin-1b (IL-1b) in blood sample from baseline to week 9
SecondaryIL-1b, CSF: biomarker of inflammation9 weeksChange in levels of interleukin-1b (IL-1b) in cerebrospinal fluid sample from baseline to week 9
SecondaryIFN-y, blood: biomarker of inflammation9 weeksChange in levels of interferon gamma (IFN-y) in blood sample from baseline to week 9
SecondaryIFN-y, CSF: fluid biomarker of inflammation9 weeksChange in levels of interferon gamma (IFN-y) in cerebrospinal fluid sample from baseline to week 9
Secondaryhs-CRP, blood: biomarker of inflammation9 weeksChange in levels of high-sensitivity C-reactive peptide (hs-CRP) in blood sample from baseline to week 9
Secondaryhs-CRP, CSF: biomarker of inflammation9 weeksChange in levels of high-sensitivity C-reactive peptide (hs-CRP) in cerebrospinal fluid from baseline to week 9

Source ClinicalTrials.govtrials-2026-11-12-0.4.0

Sources 3

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ClinicalTrials.govNone stated
  • NIH RePORTER's clinical studies and project filesPublic domain
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ClinicalTrials.govnone stated
  • NIH RePORTER's clinical studies and project filesPublic domain (NIH RePORTER)

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

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