Trial · NCT05356195
Registered outcomes14
Each outcome the trial registered, primary first, in ClinicalTrials.gov's words.
1 to 14 of 14
Download this page as JSON| List | Outcome | Time frame | Description |
|---|---|---|---|
| Primary | Proportion of Participants who Achieve Transfusion Independence for at Least 12 Consecutive Months (TI12) | Up to 24 Months After CTX001 Infusion | |
| Secondary | Proportion of Participants Achieving at Least 95 Percent (%), 90%, 85%, 75% and 50% Reduction in Annualized Transfusions | From Baseline up to 24 Months After CTX001 Infusion | |
| Secondary | Transfusion Free Duration for Participants who Achieve TI12 | Up to 24 Months After CTX001 Infusion | |
| Secondary | Proportion of Alleles With Intended Genetic Modification Present in Peripheral Blood Over Time | Up to 24 Months After CTX001 Infusion | |
| Secondary | Proportion of Alleles With Intended Genetic Modification Present in CD34+ Cells of the Bone Marrow Over Time | Up to 24 Months After CTX001 Infusion | |
| Secondary | Change in Fetal Hemoglobin Concentration Over Time | From Baseline (Pre-transfusion) up to 24 Months After CTX001 Infusion | |
| Secondary | Change in Total Hemoglobin Concentration Over Time | From Baseline (Pre-transfusion) up to 24 Months After CTX001 Infusion | |
| Secondary | Number of Participants With Adverse Events (AEs) and Serious Adverse Events (SAEs) | From Signing of Informed Consent up to 24 Months After CTX001 Infusion | |
| Secondary | Proportion of Participants With Engraftment (First day of 3 Consecutive Measurements of Absolute Neutrophil Count [ANC] ≥500 per Microliter [mcgL] on 3 Different Days) | Within 42 Days After CTX001 Infusion | |
| Secondary | Time to Engraftment | Up to 24 Months After CTX001 Infusion | |
| Secondary | Incidence of Transplant-related Mortality (TRM) Within 100 Days After CTX001 Infusion | Within 100 Days After CTX001 Infusion | |
| Secondary | Incidence of TRM Within 12 Months After CTX001 Infusion | Within 12 Months After Infusion | |
| Secondary | Incidence of All-cause Mortality | From Signing of Informed Consent up to 24 Months After CTX001 Infusion | |
| Secondary | Relative Reduction in Annualized Volume and Episodes of RBC Transfusions starting Month 10 After CTX001 infusion | From Baseline up to 24 Months After CTX001 Infusion |
Source ClinicalTrials.govtrials-2026-11-12-0.5.0
Sources 3
- ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
- ClinicalTrials.govNo license stated
- NIH RePORTER's clinical studies and project filesPublic domain
Each source's terms
- ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
- ClinicalTrials.govnone stated
- NIH RePORTER's clinical studies and project filesPublic domain (NIH RePORTER)
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.
For software
Read this list from software.
Twenty rows a page, as JSON. No key.
GET https://conductscience.org/api/trials/v1/NCT05356195/registered