Trial · NCT05361499
A Controlled Human Pneumococcal Infection Model (PIM) Study
NCT05361499, Not applicable, Completed, Radboud University Medical Center
3 sourcestrials-2026-11-12-0.5.0
Cite this record
ConductScience Library. A Controlled Human Pneumococcal Infection Model (PIM) Study. Trials, record NCT05361499. Release trials-2026-11-12-0.5.0, 12 Nov 2026. https://conductscience.org/library/trials/NCT05361499
On this page
Trial
As registered on ClinicalTrials.gov, in the graph's capture of the registry.
- Title
- A Controlled Human Pneumococcal Infection Model (PIM) Study
- NCT number
- NCT05361499
- Status
- Completed
- Phases
- Not applicable
- Enrollment
- 20 participants, actual
- Lead sponsor
- Radboud University Medical Center
- Conditions
- Streptococcus Pneumoniae Infection
- Interventions
- Sp_6B, Amoxicillin 500 mg
- First posted
- 2022-05-04
- Last updated
- 2023-02-22
Source ClinicalTrials.gov
Registered outcomes12
Each outcome the trial registered, primary first, in ClinicalTrials.gov's words.
| List | Outcome | Time frame | Description |
|---|---|---|---|
| Primary | Percentage of volunteers infected with S. pneumoniae serotype 6B following inoculation. | up to 4 weeks after inoculation | |
| Secondary | The number of participants with sollicited AEs that are related to infection | from the baseline visit (between day -1 and -6) till the end of the study (day 28 ± 3) | |
| Secondary | The number, type and severity of sollicited AEs that are related to infection | from the baseline visit (between day -1 and -6) till the end of the study (day 28 ± 3) | |
| Secondary | Number of sampling timepoints with S. pneumoniae culture-positive nasal wash samples post-inoculation | On day 3, 7, 14 and 28 after inoculation | |
| Secondary | Number of colony forming units (CFUs) per ml detected in nasal wash of infected participants at each sampling timepoint | On day 3, 7, 14 and 28 after inoculation | |
| Secondary | Concentrations of S. pneumoniae-specific antibodies in blood and mucosal samples at the various sampling time points | On day 3, 7, 14 and 28 after inoculation | |
| Other | Bacterial load as determined by PCR of pneumococcal genes at each sampling time point | On day 3, 7, 14 and 28 after inoculation | |
| Other | Cellular responses in blood and mucosal samples at various timepoints | On day 3, 7, 14 and 28 after inoculation | |
| Other | Soluble mediators in mucosal or blood samples at various timepoints | On day 3, 7, 14 and 28 after inoculation | |
| Other | Expression level of host genes at various timepoints | On day 3, 7, 14 and 28 after inoculation |
1 to 10 of 12Source ClinicalTrials.gov
See all 12 registered outcomesOutcomes0
Each outcome the trial posted results for, in ClinicalTrials.gov's words.
None in this release.
Results by group0
Each measurement the trial posted, group by group, in the words and numbers it posted.
None in this release.
Participant flow0
How many started, completed or left each group, period by period.
None in this release.
Adverse events0
Each adverse event the trial posted, group by group: the participants affected out of those at risk.
None in this release.
Adverse event totals0
The totals the trial posted for each group.
None in this release.
Papers0
The papers the trial lists on ClinicalTrials.gov.
None in this release.
Grants0
The grants NIH RePORTER links to the trial, newest funded first: NIH's, and some of AHRQ's, CDC's, FDA's and VA's. Each shows its title, principal investigators, organization and funder in its newest year.
None in this release.
Trial comparisons0
Comparisons of the trial's two groups, calculated by ConductScience from the counts it posted.
None in this release.
Tests0
The ConductCognition tests this trial's registered outcomes name, as ScienceGraph matched them in trial-tests-2026-11-12-0.2.1.
None in this release.
Data dates
The day each source was copied for this release.
Sources 3
- ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
- ClinicalTrials.govNo license stated
- NIH RePORTER's clinical studies and project filesPublic domain
Each source's terms
- ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
- ClinicalTrials.govnone stated
- NIH RePORTER's clinical studies and project filesPublic domain (NIH RePORTER)
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.
For software
Read this trial from software.
The record and each of its lists are JSON, twenty rows a page. No key.
GET https://conductscience.org/api/trials/v1/NCT05361499
GET https://conductscience.org/api/trials/v1/NCT05361499/registered