Trial · NCT05382208
Doxycycline for Emphysema in People Living With HIV (The DEPTH Trial)
NCT05382208, Phase 2, Active not recruiting, Weill Medical College of Cornell University
3 sourcestrials-2026-11-12-0.5.0
Cite this record
ConductScience Library. Doxycycline for Emphysema in People Living With HIV (The DEPTH Trial). Trials, record NCT05382208. Release trials-2026-11-12-0.5.0, 12 Nov 2026. https://conductscience.org/library/trials/NCT05382208
On this page
Trial
As registered on ClinicalTrials.gov, in the graph's capture of the registry.
- Title
- Doxycycline for Emphysema in People Living With HIV (The DEPTH Trial)
- NCT number
- NCT05382208
- Status
- Active not recruiting
- Phases
- Phase 2
- Enrollment
- 133 participants, actual
- Lead sponsor
- Weill Medical College of Cornell University
- Conditions
- Emphysema, HIV
- Interventions
- Doxycycline, Placebo
- First posted
- 2022-05-19
- Last updated
- 2026-01-26
Source ClinicalTrials.gov
Registered outcomes23
Each outcome the trial registered, primary first, in ClinicalTrials.gov's words.
| List | Outcome | Time frame | Description |
|---|---|---|---|
| Primary | Rate of decline (slope) of percent predicted diffusing capacity for carbon monoxide (DLCO) corrected for hemoglobin, carboxyhemoglobin and barometric pressure (indicated as ppDLCOadj) over the 72 week treatment period. | 72 weeks | |
| Secondary | Change from baseline to week 48 in 6 minute walk test distance. | 48 weeks | |
| Secondary | Change from baseline to week 72 in 6 minute walk test distance. | 72 weeks | |
| Secondary | Change from baseline to week 48 in percent predicted diffusing capacity for carbon monoxide (DLCO) corrected for hemoglobin, carboxyhemoglobin and barometric pressure (ppDLCOadj). | 48 weeks | |
| Secondary | Change from baseline to week 72 in percent predicted diffusing capacity for carbon monoxide (DLCO) corrected for hemoglobin, carboxyhemoglobin and barometric pressure (ppDLCOadj). | 72 weeks | |
| Secondary | Change from baseline to week 72 in percentage of voxels < -950 Hounsfield Units (HU) | 72 weeks | |
| Secondary | Change from baseline to week 48 in the COPD Activity Test (CAT) score | 48 weeks | The COPD Assessment Test (CAT): CAT is an 8-item self-administered questionnaire. Scores range from 0 to 40. Higher scores denote a more severe impact of COPD on a patient's life. |
| Secondary | Change from baseline to week 72 in the COPD Activity Test (CAT) score | 72 weeks | The COPD Assessment Test (CAT): CAT is an 8-item self-administered questionnaire. Scores range from 0 to 40. Higher scores denote a more severe impact of COPD on a patient's life. |
| Secondary | Change from baseline to week 48 in St. George's Respiratory Questionnaire (SGRQ) score | 48 weeks | St. George's Respiratory Questionnaire (SGRQ): SGRQ is a 50-item respiratory disease-specific health-related quality of life (HRQOL) instrument designed to measure impact on overall health, daily life, and perceived well-being in patients with obstructive airways disease. Scores range from 0 to 100, with higher scores indicating more limitations. |
| Secondary | Change from baseline to week 72 in St. George's Respiratory Questionnaire (SGRQ) score | 72 weeks | St. George's Respiratory Questionnaire (SGRQ): SGRQ is a 50-item respiratory disease-specific health-related quality of life (HRQOL) instrument designed to measure impact on overall health, daily life, and perceived well-being in patients with obstructive airways disease. Scores range from 0 to 100, with higher scores indicating more limitations. |
1 to 10 of 23Source ClinicalTrials.gov
See all 23 registered outcomesOutcomes0
Each outcome the trial posted results for, in ClinicalTrials.gov's words.
None in this release.
Results by group0
Each measurement the trial posted, group by group, in the words and numbers it posted.
None in this release.
Participant flow0
How many started, completed or left each group, period by period.
None in this release.
Adverse events0
Each adverse event the trial posted, group by group: the participants affected out of those at risk.
None in this release.
Adverse event totals0
The totals the trial posted for each group.
None in this release.
Papers1
The papers the trial lists on ClinicalTrials.gov.
| PMID | Listed as |
|---|---|
| 42852919 | DERIVED |
Source PubMed
Grants2
The grants NIH RePORTER links to the trial, newest funded first: NIH's, and some of AHRQ's, CDC's, FDA's and VA's. Each shows its title, principal investigators, organization and funder in its newest year.
| Project | Title | Principal investigators | Organization | Funder | Fiscal years | Source |
|---|---|---|---|---|---|---|
| UH3HL154944 | 1/2 Doxycycline for Emphysema in People Living with HIV: The DEPTH Trial | KANER, ROBERT J; GLESBY, MARSHALL J | WEILL MEDICAL COLL OF CORNELL UNIV | NATIONAL HEART, LUNG, AND BLOOD INSTITUTE | 2022 to 2024 | NIH RePORTER |
| UG3HL154944 | 1/2 Doxycycline for Emphysema in People Living with HIV: The DEPTH Trial | KANER, ROBERT J; GLESBY, MARSHALL J | WEILL MEDICAL COLL OF CORNELL UNIV | NATIONAL HEART, LUNG, AND BLOOD INSTITUTE | 2021 | NIH RePORTER |
Trial comparisons0
Comparisons of the trial's two groups, calculated by ConductScience from the counts it posted.
None in this release.
Tests0
The ConductCognition tests this trial's registered outcomes name, as ScienceGraph matched them in trial-tests-2026-11-12-0.2.1.
None in this release.
Data dates
The day each source was copied for this release.
Sources 3
- ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
- ClinicalTrials.govNo license stated
- NIH RePORTER's clinical studies and project filesPublic domain
Each source's terms
- ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
- ClinicalTrials.govnone stated
- NIH RePORTER's clinical studies and project filesPublic domain (NIH RePORTER)
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.
For software
Read this trial from software.
The record and each of its lists are JSON, twenty rows a page. No key.
GET https://conductscience.org/api/trials/v1/NCT05382208
GET https://conductscience.org/api/trials/v1/NCT05382208/registered?page=2