Trial · NCT05405894
Efficacy of Zoledronic Acid to Prevent Bone Loss Following Denosumab Discontinuation
NCT05405894, Unknown, University of Calgary
3 sourcestrials-2026-11-12-0.5.0
Cite this record
ConductScience Library. Efficacy of Zoledronic Acid to Prevent Bone Loss Following Denosumab Discontinuation. Trials, record NCT05405894. Release trials-2026-11-12-0.5.0, 12 Nov 2026. https://conductscience.org/library/trials/NCT05405894
On this page
Trial
As registered on ClinicalTrials.gov, in the graph's capture of the registry.
- Title
- Efficacy of Zoledronic Acid to Prevent Bone Loss Following Denosumab Discontinuation
- NCT number
- NCT05405894
- Status
- Unknown
- Enrollment
- 20 participants, estimated
- Lead sponsor
- University of Calgary
- Conditions
- Osteoporosis, Osteoporosis, Postmenopausal, Osteopenia, Bone Loss
- Interventions
- Zoledronic acid
- First posted
- 2022-06-06
- Last updated
- 2024-05-14
Source ClinicalTrials.gov
Registered outcomes6
Each outcome the trial registered, primary first, in ClinicalTrials.gov's words.
| List | Outcome | Time frame | Description |
|---|---|---|---|
| Primary | Change in volumetric Bone Mineral Density (BMD)/bone microarchitecture from baseline | Change from Baseline (within 1-month of infusion) to 6-months and 12-months | High-resolution peripheral computed tomography scan (radius and tibia) will be used to quantify volumetric BMD/bone microarchitecture |
| Primary | Change in areal Bone Mineral Density (BMD) from baseline | Change from Baseline (within 1-month of infusion) to 6-months and 12-months | Dual X-ray absorptiometry scan (lumbar spine, lateral vertebral assessment, and hip) will be used to quantify areal BMD |
| Secondary | Fractures | 1 year | Any clinically diagnosed fractures will be reported by treating physician |
| Secondary | MoJo Fracture Risk Questionnaire | 1 year | An assessment of fracture risk |
| Other | Optional further assessment of change in volumetric Bone Mineral Density (BMD)/bone microarchitecture from baseline | Change from Baseline to 24-months | High-resolution peripheral computed tomography scan (radius and tibia) will be used to quantify volumetric BMD/bone microarchitecture |
| Other | Optional further assessment of change in areal Bone Mineral Density (BMD) from baseline | Change from Baseline to 24-months | Dual X-ray absorptiometry scan (lumbar spine, lateral vertebral assessment, and hip) will be used to quantify areal BMD |
Source ClinicalTrials.gov
Outcomes0
Each outcome the trial posted results for, in ClinicalTrials.gov's words.
None in this release.
Results by group0
Each measurement the trial posted, group by group, in the words and numbers it posted.
None in this release.
Participant flow0
How many started, completed or left each group, period by period.
None in this release.
Adverse events0
Each adverse event the trial posted, group by group: the participants affected out of those at risk.
None in this release.
Adverse event totals0
The totals the trial posted for each group.
None in this release.
Papers2
The papers the trial lists on ClinicalTrials.gov.
Grants0
The grants NIH RePORTER links to the trial, newest funded first: NIH's, and some of AHRQ's, CDC's, FDA's and VA's. Each shows its title, principal investigators, organization and funder in its newest year.
None in this release.
Trial comparisons0
Comparisons of the trial's two groups, calculated by ConductScience from the counts it posted.
None in this release.
Tests0
The ConductCognition tests this trial's registered outcomes name, as ScienceGraph matched them in trial-tests-2026-11-12-0.2.1.
None in this release.
Data dates
The day each source was copied for this release.
Sources 3
- ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
- ClinicalTrials.govNo license stated
- NIH RePORTER's clinical studies and project filesPublic domain
Each source's terms
- ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
- ClinicalTrials.govnone stated
- NIH RePORTER's clinical studies and project filesPublic domain (NIH RePORTER)
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.
For software
Read this trial from software.
The record and each of its lists are JSON, twenty rows a page. No key.
GET https://conductscience.org/api/trials/v1/NCT05405894
GET https://conductscience.org/api/trials/v1/NCT05405894/registered