Biobehavioral Reward Responses Associated With Consumption of Nutritionally Diverse Ultra-Processed Foods
NCT05437809, Not applicable, Active not recruiting, Oregon Research Institute
Trial 10
As registered on ClinicalTrials.gov, in the graph's capture of the registry.
| Field | Value | Source |
|---|---|---|
| Title | Biobehavioral Reward Responses Associated With Consumption of Nutritionally Diverse Ultra-Processed Foods | ClinicalTrials.gov |
| NCT number | NCT05437809 | ClinicalTrials.gov |
| Status | Active not recruiting | ClinicalTrials.gov |
| Phases | Not applicable | ClinicalTrials.gov |
| Enrollment | 50 participants, estimated | ClinicalTrials.gov |
| Lead sponsor | Oregon Research Institute | ClinicalTrials.gov |
| Conditions | Obesity, Overeating, Food Addiction | ClinicalTrials.gov |
| Interventions | Intake of nutritionally diverse ultra-processed foods | ClinicalTrials.gov |
| First posted | 2022-06-29 | ClinicalTrials.gov |
| Last updated | 2026-09-18 | ClinicalTrials.gov |
Registered outcomes 9
Each outcome the trial registered, primary first, in ClinicalTrials.gov's words.
| List | Outcome | Time frame | Description | Source |
|---|---|---|---|---|
| Primary | Subjective reward responses to food intake (in lab) | 10 minutes before intake of test snack, during, and 30-, 60-, 90-, and 120 minutes after intake of the test snack. | Indicators of subjective reward (craving, palatability, hedonic hunger, and mood) will be assessed by participants' self-reports before, during, and after consumption of the test snack at each of the four food consumption appointments. Each facet of subjective reward will be assessed by 100-point visual analog scales ranging from 0-100. | ClinicalTrials.gov |
| Primary | Subjective reward responses to food intake (EMA) | EMA surveys administered over 5 days following each food consumption assessment (20 total days of EMA data) | Indicators of subjective reward (craving, palatability, hedonic hunger, and mood) will be assessed by participants' self-reports in EMA surveys. Each facet of subjective reward will be assessed by 100-point visual analog scales ranging from 0-100. | ClinicalTrials.gov |
| Primary | Ad libitum consumption | 2 hours after test snack intake at each food consumption assessment. | Total number of calories consumed from the test snack food during a 15-minute eating period. Calories will calculated by measuring bowls containing the test snacks before and after participant consumption on a digital scale accurate to 0.01 grams. The difference in grams will be converted into the calories that the participant ate. | ClinicalTrials.gov |
| Primary | Daily calorie intake (EMA) | EMA surveys administered over 5 days following each food consumption assessment (20 total days of EMA data) | Calorie intake will be derived from participants' self-reported food consumption in EMA surveys. | ClinicalTrials.gov |
| Primary | Consumption of UPFs and MPFs (EMA) | EMA surveys administered over 5 days following each food consumption assessment (20 total days of EMA data) | Trained study staff will calculate the percentage of participants' daily calories from the four food categories (UPF+FRC, UPF+F, UPF+RC, MPF) based on participants' self-reported food consumption in EMA surveys. | ClinicalTrials.gov |
| Secondary | Changes in heart rate in response to food intake | 10 minutes before intake of test snack, during, and 30-, 60-, 90-, and 120 minutes after intake of the test snack. | Manually measured by counting the radial pulse for 15 seconds (timed using a digital stopwatch). | ClinicalTrials.gov |
| Secondary | Salivation responses to food intake | 10 minutes before intake of test snack, during, and 30-, 60-, 90-, and 120 minutes after intake of the test snack. | Participants will spit into a plastic cup for 1 minute and the weight of their saliva will be measured in grams using a digital food scale accurate to 0.01 grams. | ClinicalTrials.gov |
| Secondary | Magnitude of metabolic responses to food intake | 10 minutes before intake of test snack, during, and 30-, 60-, 90-, and 120 minutes after intake of the test snack. | Serial blood draws will be conducted before, during, and after test snack consumption. Samples will be assayed for glucose, insulin, ghrelin, and leptin levels. | ClinicalTrials.gov |
| Other | Individual risk factors for enhanced ultra-processed food reward | Tasks administered at baseline assessment (prior to any food consumption appointments) or follow-up assessment (at least one week or up to 2 months after the last food consumption appointment) | Characteristics known to increase one's reward responsiveness to substances like alcohol will be assessed by behavioral tasks and evaluated as predictors of ultra-processed food reward (delay discounting task to assess impulsivity; Stroop task to assess cognitive functioning; relative reinforcing value task to assess reward value of various foods). | ClinicalTrials.gov |
Outcomes 0
Each outcome the trial posted results for, in ClinicalTrials.gov's words.
| Type | Outcome | Time frame | Population | Units | Measured as | Source |
|---|
Results by group 0
Each measurement the trial posted, group by group, in the words and numbers it posted.
| Outcome | Group | Category | Value | Spread | Units | Source |
|---|
Participant flow 0
How many started, completed or left each group, period by period.
| Period | Milestone | Group | Participants | Units counted | Source |
|---|
Adverse events 0
Each adverse event the trial posted, group by group: the participants affected out of those at risk.
| Type | Event | Organ system | Group | Affected | At risk | Events | Source |
|---|
Adverse event totals 0
The totals the trial posted for each group.
| Total | Group | Affected | At risk | Source |
|---|
Papers 0
The papers the trial lists on ClinicalTrials.gov.
| PMID | Listed as | Source |
|---|
Grants 1
The grants NIH RePORTER links to the trial, newest funded first: NIH's, and some of AHRQ's, CDC's, FDA's and VA's. Each shows its title, principal investigators, organization and funder in its newest year.
| Project | Title | Principal investigators | Organization | Funder | Fiscal years | Source |
|---|---|---|---|---|---|---|
| K23DK129825 | Biobehavioral Reward Responses Associated with Consumption of Nutritionally Diverse Ultra-Processed Foods | LAFATA, ERICA M | ORI COMMUNITY AND EVALUATION SERVICES | NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES | 2022 to 2025 | NIH RePORTER |
Trial comparisons 0
Comparisons of the trial's two groups, calculated by ConductScience from the counts it posted.
| Comparison | Source |
|---|
Tests 2
The ConductCognition tests this trial's registered outcomes name, as ScienceGraph matched them in trial-tests-2026-11-12-0.2.1.
| Test | Named as | Source |
|---|---|---|
| Delay Discounting | Other outcome | ConductCognition |
| Stroop Color-Word Test | Other outcome | ConductCognition |
Source 5
| Field | Value | Source |
|---|---|---|
| Release | trials-2026-11-12-0.4.0 | ClinicalTrials.gov |
| Release manifest SHA-256 | 0f4a8d8c48aee2a7573ae0fa94ecbeab70c1adbe449bbc95c424bc7d3e97b9d4 | ClinicalTrials.gov |
| Registry capture | 2026-11-12 | ClinicalTrials.gov |
| Results copy, AACT | 2026-03-23 | ClinicalTrials.gov |
| NIH clinical studies file | 2026-11-13 | ClinicalTrials.gov |
Release trials-2026-11-12-0.4.0
ClinicalTrials.gov's posted results, through CTTI's AACT: ClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299 ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.
ClinicalTrials.gov: none stated ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.
NIH RePORTER's clinical studies and project files: Public domain (NIH RePORTER)