Trial · NCT05446480
Role of Desloratadine in Reducing Inflammation From Occupational Heat Strain
NCT05446480, Not applicable, Unknown, University of Victoria
3 sourcestrials-2026-11-12-0.5.0
Cite this record
ConductScience Library. Role of Desloratadine in Reducing Inflammation From Occupational Heat Strain. Trials, record NCT05446480. Release trials-2026-11-12-0.5.0, 12 Nov 2026. https://conductscience.org/library/trials/NCT05446480
On this page
Trial
As registered on ClinicalTrials.gov, in the graph's capture of the registry.
- Title
- Role of Desloratadine in Reducing Inflammation From Occupational Heat Strain
- NCT number
- NCT05446480
- Status
- Unknown
- Phases
- Not applicable
- Enrollment
- 12 participants, estimated
- Lead sponsor
- University of Victoria
- Conditions
- Heat Stress, Exertional, Inflammatory Response, Firefighter Personal Protective Equipment
- Interventions
- Desloratadine, Placebo, No Intervention
- First posted
- 2022-07-06
- Last updated
- 2022-07-06
Source ClinicalTrials.gov
Registered outcomes9
Each outcome the trial registered, primary first, in ClinicalTrials.gov's words.
| List | Outcome | Time frame | Description |
|---|---|---|---|
| Primary | Change in serum cortisol | Before, immediately following, and 2-hours following exertional heat strain | Assessment of changes in serum cortisol within and between interventions measured via venipuncture and ELISA |
| Primary | Change in serum interleukin-6 and ELISA | Before, immediately following, and 2-hours following exertional heat strain | Assessment of changes in serum interleukin-6 within and between interventions measured via venipuncture and ELISA |
| Primary | Change in serum c-reactive protein | Before, immediately following, and 24, 48, and 72-hours following exertional heat strain | Assessment of changes in serum c-reactive protein within and between interventions measured via venipuncture and ELISA |
| Primary | Change in serum tumor necrosis factor alpha | Before, immediately following, and 2-hours following exertional heat strain | Assessment of changes in serum tumor necrosis factor alpha within and between interventions measured via venipuncture and ELISA. |
| Secondary | Change in body mass | Before and immediately after exertional heat strain | Trial arm differences in fluid loss estimated via differences between before-after body mass. |
| Secondary | Differences in core body heat storage | Before and immediately after exertional heat strain | Trial arm differences in the change in core body temperature during heating. |
| Other | Differences in Cerebral Blood Flow | Before and immediately after (following assessment of outcome 8 and 9) exertional heat strain | Within and between intervention differences in cerebral blood flow changes via vascular duplex ultrasound and hypercapnia |
| Other | Differences in heart rate (HR) and heart rate variability (HRV) | Before and immediately after exertional heat strain | Within and between intervention differences in HR and HRV |
| Other | Differences in brain blood oxygenation of prefrontal cortex | Before and immediately after exertional heat strain | Within and between intervention differences in prefrontal cortex oxygenation via near-infrared spectroscopy |
Source ClinicalTrials.gov
Outcomes0
Each outcome the trial posted results for, in ClinicalTrials.gov's words.
None in this release.
Results by group0
Each measurement the trial posted, group by group, in the words and numbers it posted.
None in this release.
Participant flow0
How many started, completed or left each group, period by period.
None in this release.
Adverse events0
Each adverse event the trial posted, group by group: the participants affected out of those at risk.
None in this release.
Adverse event totals0
The totals the trial posted for each group.
None in this release.
Papers0
The papers the trial lists on ClinicalTrials.gov.
None in this release.
Grants0
The grants NIH RePORTER links to the trial, newest funded first: NIH's, and some of AHRQ's, CDC's, FDA's and VA's. Each shows its title, principal investigators, organization and funder in its newest year.
None in this release.
Trial comparisons0
Comparisons of the trial's two groups, calculated by ConductScience from the counts it posted.
None in this release.
Tests0
The ConductCognition tests this trial's registered outcomes name, as ScienceGraph matched them in trial-tests-2026-11-12-0.2.1.
None in this release.
Data dates
The day each source was copied for this release.
Sources 3
- ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
- ClinicalTrials.govNo license stated
- NIH RePORTER's clinical studies and project filesPublic domain
Each source's terms
- ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
- ClinicalTrials.govnone stated
- NIH RePORTER's clinical studies and project filesPublic domain (NIH RePORTER)
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.
For software
Read this trial from software.
The record and each of its lists are JSON, twenty rows a page. No key.
GET https://conductscience.org/api/trials/v1/NCT05446480
GET https://conductscience.org/api/trials/v1/NCT05446480/registered