Intermittent Hypoxic Training (IHT) Versus Hyperbaric Oxygen Therapy (HBOT) for Aerobic Performance
NCT05447416, Not applicable, Recruiting, Assaf-Harofeh Medical Center
Trial 10
As registered on ClinicalTrials.gov, in the graph's capture of the registry.
| Field | Value | Source |
|---|---|---|
| Title | Intermittent Hypoxic Training (IHT) Versus Hyperbaric Oxygen Therapy (HBOT) for Aerobic Performance | ClinicalTrials.gov |
| NCT number | NCT05447416 | ClinicalTrials.gov |
| Status | Recruiting | ClinicalTrials.gov |
| Phases | Not applicable | ClinicalTrials.gov |
| Enrollment | 66 participants, estimated | ClinicalTrials.gov |
| Lead sponsor | Assaf-Harofeh Medical Center | ClinicalTrials.gov |
| Conditions | Healthy Active Athletes | ClinicalTrials.gov |
| Interventions | Hyperbaric Oxygen Therapy - HBOT, Intermittent Hypoxic Training - IHT | ClinicalTrials.gov |
| First posted | 2022-07-07 | ClinicalTrials.gov |
| Last updated | 2026-04-21 | ClinicalTrials.gov |
Registered outcomes 15
Each outcome the trial registered, primary first, in ClinicalTrials.gov's words.
| List | Outcome | Time frame | Description | Source |
|---|---|---|---|---|
| Primary | Cardiopulmonary exercise test (CPET) | Baseline, 11 weeks | CPET determines the gas exchange dynamics that is expected to change through the intervention | ClinicalTrials.gov |
| Secondary | Cardiopulmonary exercise test (CPET) | 8 weeks, 16 weeks | CPET determines the gas exchange dynamics that is expected to change through the intervention | ClinicalTrials.gov |
| Secondary | Time To Exhaustion | Baseline, 11 weeks, 16 weeks | The test will be conducted on the SRM high performance ergometer on 105% of the maximal aerobic power | ClinicalTrials.gov |
| Secondary | Wingate 30 seconds anaerobic test | Baseline, 11 weeks, 16 weeks | The Wingate Anaerobic Test (WAnT) is conducted on the SRM high performance ergometer. | ClinicalTrials.gov |
| Secondary | Muscle biopsy for mitochondrial function | Baseline, 11 weeks | Participants will undergo a muscle biopsy, muscle sample will be analyzed using the Oxygraph (Oroboros Inc, Austria) for oxygen respiratory function, as well as staining for mitochondrial proteins | ClinicalTrials.gov |
| Secondary | Blood test for evaluation of CBC | Baseline, 11 weeks, 16 weeks | complete blood count | ClinicalTrials.gov |
| Secondary | Blood test for evaluation of HIF-1α | Baseline, 7 weeks, 8 weeks, 11 weeks, 16 weeks | Hypoxic inducible factor 1α levels | ClinicalTrials.gov |
| Secondary | Blood test for evaluation of Telomeres length | Baseline,11 weeks, 16 weeks | Using staining and FACS technology telomere length will be analyzed | ClinicalTrials.gov |
| Secondary | Blood test for evaluation of mitochondrial function | Baseline,11 weeks | Mitochondrial function of Peripheral Blood Mononuclear Cells (PBMC) and Platelets (PLT) | ClinicalTrials.gov |
| Other | Cognitive Function | Baseline, 11 weeks | Cognitive function will be evaluated using the Neurotrax computerized cognitive assessment and the Cambridge Neuropsychological Test Automated Battery (CANTAB). | ClinicalTrials.gov |
| Other | Cognitive Function under exercise | Baseline, 11 weeks | Participants will be asked to pedal on a bike on workload correlated to 85% of the second ventilatory threshold obtained during the CPET and will simultaneously perform a Stroop test using the EncephalApp Stroop Test application on a tablet. | ClinicalTrials.gov |
| Other | Whole-brain quantitative perfusion imaging | Baseline, 11 weeks | Whole-brain quantitative perfusion imaging will be performed using Dynamic susceptibility contrast (DSC)-MRI technique | ClinicalTrials.gov |
| Other | Brain microstructure MRI evaluation | Baseline, 11 weeks | Fractional anisotropy (FA) and Mean diffusivity (MD) will be evaluated using diffusion tensor imaging (DTI) MRI protocol | ClinicalTrials.gov |
| Other | Brain functional connectivity imaging | Baseline, 11 weeks | Resting state functional MRI | ClinicalTrials.gov |
| Other | Pulse Rate variability and activity | baseline to 16 weeks | Participants will be asked to wear a smartwatch (Garmin, USA) in the entire time frame of the study. | ClinicalTrials.gov |
Outcomes 0
Each outcome the trial posted results for, in ClinicalTrials.gov's words.
| Type | Outcome | Time frame | Population | Units | Measured as | Source |
|---|
Results by group 0
Each measurement the trial posted, group by group, in the words and numbers it posted.
| Outcome | Group | Category | Value | Spread | Units | Source |
|---|
Participant flow 0
How many started, completed or left each group, period by period.
| Period | Milestone | Group | Participants | Units counted | Source |
|---|
Adverse events 0
Each adverse event the trial posted, group by group: the participants affected out of those at risk.
| Type | Event | Organ system | Group | Affected | At risk | Events | Source |
|---|
Adverse event totals 0
The totals the trial posted for each group.
| Total | Group | Affected | At risk | Source |
|---|
Papers 0
The papers the trial lists on ClinicalTrials.gov.
| PMID | Listed as | Source |
|---|
Grants 0
The grants NIH RePORTER links to the trial, newest funded first: NIH's, and some of AHRQ's, CDC's, FDA's and VA's. Each shows its title, principal investigators, organization and funder in its newest year.
| Project | Title | Principal investigators | Organization | Funder | Fiscal years | Source |
|---|
Trial comparisons 0
Comparisons of the trial's two groups, calculated by ConductScience from the counts it posted.
| Comparison | Source |
|---|
Tests 1
The ConductCognition tests this trial's registered outcomes name, as ScienceGraph matched them in trial-tests-2026-11-12-0.2.1.
| Test | Named as | Source |
|---|---|---|
| Stroop Color-Word Test | Other outcome | ConductCognition |
Source 5
| Field | Value | Source |
|---|---|---|
| Release | trials-2026-11-12-0.4.0 | ClinicalTrials.gov |
| Release manifest SHA-256 | 0f4a8d8c48aee2a7573ae0fa94ecbeab70c1adbe449bbc95c424bc7d3e97b9d4 | ClinicalTrials.gov |
| Registry capture | 2026-11-12 | ClinicalTrials.gov |
| Results copy, AACT | 2026-03-23 | ClinicalTrials.gov |
| NIH clinical studies file | 2026-11-13 | ClinicalTrials.gov |
Release trials-2026-11-12-0.4.0
ClinicalTrials.gov's posted results, through CTTI's AACT: ClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299 ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.
ClinicalTrials.gov: none stated ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.
NIH RePORTER's clinical studies and project files: Public domain (NIH RePORTER)