Trial · NCT05469165
Serotonin Receptor Blockers in Ischemic Mitral Regurgitation
NCT05469165, Phase 2, Recruiting, Laval University
3 sourcestrials-2026-11-12-0.5.0
Cite this record
ConductScience Library. Serotonin Receptor Blockers in Ischemic Mitral Regurgitation. Trials, record NCT05469165. Release trials-2026-11-12-0.5.0, 12 Nov 2026. https://conductscience.org/library/trials/NCT05469165
On this page
Trial
As registered on ClinicalTrials.gov, in the graph's capture of the registry.
- Title
- Serotonin Receptor Blockers in Ischemic Mitral Regurgitation
- NCT number
- NCT05469165
- Status
- Recruiting
- Phases
- Phase 2
- Enrollment
- 214 participants, estimated
- Lead sponsor
- Laval University
- Conditions
- Ischemic Mitral Regurgitation
- Interventions
- Cyproheptadine 4 Mg Oral Tablet, Placebo
- First posted
- 2022-07-21
- Last updated
- 2023-11-15
Source ClinicalTrials.gov
Registered outcomes15
Each outcome the trial registered, primary first, in ClinicalTrials.gov's words.
| List | Outcome | Time frame | Description |
|---|---|---|---|
| Primary | Change in mitral regurgitation severity | Baseline, 3 months | Incidence of more than mild MR (MRI regurgitant fraction ≥ 20%) at 3 months (measured by MRI) |
| Secondary | Change in mitral leaflet size | Baseline, 3 months | Mitral leaflet size (3D echo) and its variation vs baseline (measured by echocardiography) |
| Secondary | Change in mitral regurgitation grade | Baseline, 3 months | Mitral regurgitation grade (measured by echocardiography). Mitral regurgitation is graded on a scale of I-IV (grade I (mild MR), grade II (moderate MR), grade III (moderate-to-severe MR) and grade IV (severe MR)). A higher mitral regurgitation grade is generally associated with a worse outcome for the patient. |
| Secondary | Change in left ventricle size | Baseline, 3 months | Left ventricle size (measured by MRI ) |
| Secondary | Change in left ventricle function | Baseline, 3 months | Left ventricle function (measured by MRI ) |
| Secondary | Incidence of other valve regurgitation | 3 months | Incidence of other valve regurgitation (more than mild) (measured by echocardiography) |
| Secondary | Change in mitral valve thickness | Baseline, 3 months | Mitral valve thickness (measured by echocardiography) |
| Secondary | Adverse events | 3 months and 1 year | Composite of: Mortality, Heart failure requiring hospital admission, Mitral valve intervention (surgical/percutaneous) |
| Secondary | Ischemic events | 3 months and 1 year | stroke and myocardial infarction |
| Secondary | Bleeding events | 3 months and 1 year | Bleeding Academic Research Consortium (BARC) definition |
1 to 10 of 15Source ClinicalTrials.gov
See all 15 registered outcomesOutcomes0
Each outcome the trial posted results for, in ClinicalTrials.gov's words.
None in this release.
Results by group0
Each measurement the trial posted, group by group, in the words and numbers it posted.
None in this release.
Participant flow0
How many started, completed or left each group, period by period.
None in this release.
Adverse events0
Each adverse event the trial posted, group by group: the participants affected out of those at risk.
None in this release.
Adverse event totals0
The totals the trial posted for each group.
None in this release.
Papers0
The papers the trial lists on ClinicalTrials.gov.
None in this release.
Grants0
The grants NIH RePORTER links to the trial, newest funded first: NIH's, and some of AHRQ's, CDC's, FDA's and VA's. Each shows its title, principal investigators, organization and funder in its newest year.
None in this release.
Trial comparisons0
Comparisons of the trial's two groups, calculated by ConductScience from the counts it posted.
None in this release.
Tests0
The ConductCognition tests this trial's registered outcomes name, as ScienceGraph matched them in trial-tests-2026-11-12-0.2.1.
None in this release.
Data dates
The day each source was copied for this release.
Sources 3
- ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
- ClinicalTrials.govNo license stated
- NIH RePORTER's clinical studies and project filesPublic domain
Each source's terms
- ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
- ClinicalTrials.govnone stated
- NIH RePORTER's clinical studies and project filesPublic domain (NIH RePORTER)
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.
For software
Read this trial from software.
The record and each of its lists are JSON, twenty rows a page. No key.
GET https://conductscience.org/api/trials/v1/NCT05469165
GET https://conductscience.org/api/trials/v1/NCT05469165/registered