Trial · NCT05493371
Empagliflozin in Pulmonary Arterial Hypertension
NCT05493371, Phase 2, Completed, Amsterdam UMC, location VUmc
3 sourcestrials-2026-11-12-0.5.0
Cite this record
ConductScience Library. Empagliflozin in Pulmonary Arterial Hypertension. Trials, record NCT05493371. Release trials-2026-11-12-0.5.0, 12 Nov 2026. https://conductscience.org/library/trials/NCT05493371
On this page
Trial
As registered on ClinicalTrials.gov, in the graph's capture of the registry.
- Title
- Empagliflozin in Pulmonary Arterial Hypertension
- NCT number
- NCT05493371
- Status
- Completed
- Phases
- Phase 2
- Enrollment
- 8 participants, actual
- Lead sponsor
- Amsterdam UMC, location VUmc
- Conditions
- Idiopathic Pulmonary Arterial Hypertension
- Interventions
- Empagliflozin 10 MG
- First posted
- 2022-08-09
- Last updated
- 2024-11-20
- Other registries' IDs
- eudract:2022-002400-20
Source ClinicalTrials.gov
Registered outcomes17
Each outcome the trial registered, primary first, in ClinicalTrials.gov's words.
| List | Outcome | Time frame | Description |
|---|---|---|---|
| Primary | Tolerability: the number of patients who have to prematurely discontinue treatment due to intolerability or adverse events. | 12 weeks | |
| Primary | Feasibility: time needed to include all patients and number of patients needed to screen. | 12 weeks | |
| Primary | Safety: the number of adverse events (AEs), severe adverse events (SAEs), adverse event of special interest (AESI) and suspected unexpected serious adverse reactions (SUSARs). | 12 weeks | |
| Secondary | Right ventricle ejection fraction (RVEF) measured using MRI | 12 weeks | RVEF is calculated using the RVESV, RVEDV |
| Secondary | Right ventricle mass measured using MRI | 12 weeks | |
| Secondary | Left ventricle ejection fraction (LVEF) measured using MRI | 12 weeks | LVEF is calculated using the LVESV, LVEDV |
| Secondary | Stroke volume (SV) measured using MRI | 12 weeks | SV is calculated using the LVESV, LVEDV |
| Secondary | Tricuspid annular plane systolic excursion (TAPSE) measured using transthoracic ultrasound | 12 weeks | |
| Secondary | Estimated sPAP measured using transthoracic ultrasound | 12 weeks | |
| Secondary | Right ventricle fractional area change (RVFAC) measured using transthoracic ultrasound | 12 weeks |
1 to 10 of 17Source ClinicalTrials.gov
See all 17 registered outcomesOutcomes0
Each outcome the trial posted results for, in ClinicalTrials.gov's words.
None in this release.
Results by group0
Each measurement the trial posted, group by group, in the words and numbers it posted.
None in this release.
Participant flow0
How many started, completed or left each group, period by period.
None in this release.
Adverse events0
Each adverse event the trial posted, group by group: the participants affected out of those at risk.
None in this release.
Adverse event totals0
The totals the trial posted for each group.
None in this release.
Papers1
The papers the trial lists on ClinicalTrials.gov.
| PMID | Listed as |
|---|---|
| 42500881 | DERIVED |
Source PubMed
Grants0
The grants NIH RePORTER links to the trial, newest funded first: NIH's, and some of AHRQ's, CDC's, FDA's and VA's. Each shows its title, principal investigators, organization and funder in its newest year.
None in this release.
Trial comparisons0
Comparisons of the trial's two groups, calculated by ConductScience from the counts it posted.
None in this release.
Tests0
The ConductCognition tests this trial's registered outcomes name, as ScienceGraph matched them in trial-tests-2026-11-12-0.2.1.
None in this release.
Data dates
The day each source was copied for this release.
Sources 3
- ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
- ClinicalTrials.govNo license stated
- NIH RePORTER's clinical studies and project filesPublic domain
Each source's terms
- ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
- ClinicalTrials.govnone stated
- NIH RePORTER's clinical studies and project filesPublic domain (NIH RePORTER)
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.
For software
Read this trial from software.
The record and each of its lists are JSON, twenty rows a page. No key.
GET https://conductscience.org/api/trials/v1/NCT05493371
GET https://conductscience.org/api/trials/v1/NCT05493371/registered